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국회도서관 홈으로 정보검색 소장정보 검색

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Title Page

ABSTRACT

국문 초록

Contents

Abbreviations 13

Introduction 14

The rationale for Direction-Specific Force Generation Tasks 16

Hypotheses 17

Part I 18

1. Introduction 18

2. Materials and Methods 22

Subjects 22

Experiment setup and protocol 22

Data Processing 26

Data Analysis 27

Muscle Synergy Extraction 29

3. Results 35

Peak Force in the anterior, posterior, medial, and lateral direction tasks 35

Force Vectors in the direction-guided force generation task 38

EMG Patterns of lower limb muscles in a direction focused force generation task 40

Muscle synergies in the direction focused force generation tasks 42

Muscle Synergies Specific to Force generation direction 44

Preferred Directions of Synergies in Each of the Force Generation Tasks 45

4. Discussion 47

Peak Force, Force Vectors, and Cosine Angles in the direction-focused tasks 47

The muscle activation pattern of the lower limb muscles in the direction-based force generation task 49

Muscle Synergy in direction-guided force generation tasks 50

Muscle synergies similarity across Subjects 51

Muscle Synergies are specific to the direction of force generation direction 51

Part II 54

1. Introduction 54

2. Methods 59

Subjects Inclusion Criteria 59

Experiment Setup and Protocol 62

Data Processing 62

Data Analysis 63

Statistical Test 65

3. Results 66

Delayed Response time 66

Reduced maximal force-generating capability 67

Co-contraction index across multiple joints 69

Force Vector's Cosine Angles 70

Muscle Synergy Recruitment Patterns and Preferred Directions 72

VAF and Stroke Muscle Synergy Patterns 74

Muscle Synergy Similarities Across Groups 80

Muscle Synergy Preferred Directions Across Groups 82

4. Discussion 84

Reduced Neuromuscular Performance and Motor Control in Stroke 84

VAF and Muscle Synergy Patterns 85

Merging of Muscle Synergy Patterns in Stroke 87

Conclusion 90

Future Direction 91

Bibliography 92

List of Tables

Table 1. Subject Characterstics 61

Table 2. Stroke subjects Fugl-Meyer Clinical Assessment Scores 61

Table 3. Peak Forces generated across direction-specific force generation tasks 68

Table 4. Similarity Index for Stroke muscle synergy weights compared to healthy muscle synergy patterns 81

List of Figures

Figure 1. Experiment setup 25

Figure 2. Directional guide cues appearing in random orders 26

Figure 3. Force recorded graph from force generation tasks upon direction cues, the dashed grey vertical lines indicate the appearance and removal of directional cues. 28

Figure 4. Cosine angles/directions 28

Figure 5. The principle of non-negative matrix factorization 30

Figure 6. Muscle Synergy Extraction algorithm (NMF) 30

Figure 7. Force generated in the axes of instructed directions (anterior and posterior on the Y-axis and medial and lateral on the X-axis) during the direction-guided... 36

Figure 8. Peak forces generated during force generation task in each direction 37

Figure 9. Force output distribution of each subject on the X-Y axis for all four force instructed directions (A). The force output vector for each direction of the force-... 38

Figure 10. Cosine Angle as a measure for force vector alignment with the axis of instructed direction of force generation task. 40

Figure 11. Mean EMG compared between the instructed directions of force generation in the anterior, posterior, medial and lateral directions. 41

Figure 12. Group Muscle synergies of all force generation tasks in the anterior, posterior, medial and lateral directions. A) The Muscle synergy weights, B)... 43

Figure 13. Similarity index of muscle synergies extracted from concatenating the EMG activities of force generation in all directions and muscle synergies extracted... 45

Figure 14. Muscle Synergies preferred directions 46

Figure 15. Reaction time across directions of force generation task 66

Figure 16. Maximal force generated across the directions of force generation tasks 67

Figure 17. Co-contraction Index 69

Figure 18. Force vector cosine angles for each of the directions of force generation tasks 70

Figure 19. Muscle synergy recruitment patterns and preferred directions for the healthy group 72

Figure 20. Stroke muscle synergy recruitment patterns and each synergies preferred directions 79

Figure 21. Across Group similarities of Muscle Synergy weights and their preferred directions 82

초록보기

이 연구는 신경근 운동 제어 반응을 평가하고 건강한 개인과 뇌졸중 환자그룹의 방향별 힘 생성 작업에서 근육 시너지 모집 패턴을 식별하는데 중점을 둡니다. 운동 제어 작업은 힘 센서가 내장된 맞춤형 하지 힘제어 측정 시스템을 사용하여 수행하였습니다 22 명의 건강인과 24 명의 편마비 뇌졸중 환자를 대상으로 유도된 방향 별 힘 생성 데이터를 수집하였습니다.힘 생성 방향은 디스플레이 모니터에 표시하여 시각적으로 안내하였습니다.. 동시에하지 근육의 EMG 활동이 기록되었습니다. 결과적으로,힘 생성 과제의 각 방향 사이에서 운동 제어 반응과 사용된 근육 시너지 간에상당한 차이를 보여주었습니다.또한 각 힘 생성 작업에서 제어 그룹과 뇌졸중 환자 그룹 간의 모터 제어 응답성능에 상당한 차이가 있음을 보여주었습니다. 신경근 조절의 관점에서, 이 연구는 건강한 그룹과 뇌졸중 환자그룹 간의 운동 조절 작업의 기능적 차이를 나타냅니다. 또한 근육 시너지 분석법을 통한 방향성 운동 조절 능력 평가를 뇌졸중 환자의 재활 솔루션 개발에 활용할 수 있는 가능성을 제시한다.