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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Title Page 2

Abstract 5

Contents 7

Introduction 8

Materials and Methods 11

Results 13

Discussion 16

Conclusions 20

References 22

Figure legends 28

Table 31

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 Objectives: Amidst the COVID-19 pandemic, disinfectants have played a pivotal role in controlling the transmission of the disease, employed for hand hygiene and sanitization of various surfaces. This study endeavors to comprehensively evaluate the impacts of these disinfectants when introduced into the respiratory airway system.

Methods: In the context of disinfectant classification, this study subjected representative disinfectants, namely ethanol, hydrogen peroxide, and sodium hypochlorite, to a range of concentrations and exposure durations on respiratory cell lines and nasal mucosal tissues, investigating a spectrum of effects.

Results: Despite the brief exposure to low concentrations of all enrolled disinfectants, BEAS-2B cells exhibited a significant rise in pro-inflammatory cytokines in comparison to the control group. Notably, we observed the dissociation of the mucosal epithelial layer in response to ethanol at 1000 ppm, hydrogen peroxide at 1 ppm, and sodium hypochlorite at 10 ppm. Furthermore, a reduction in the motility of cilia, responsible for the physical defense of the epithelial layer, was evident at concentrations of 1000 ppm ethanol and 1 ppm hydrogen peroxide.

Conclusions: Disinfectants used to prevent COVID-19 may induce inflammation and tissue damage even at low concentrations in airway cells and tissues, necessitating cautious usage, even in small amounts.

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