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A benchmark dose (BMD) approach has been evaluated us a replacement for the traditional NOAEL methodology currently being wed to assess the noncancer effects of toxicants. The endocrine disrupt-ing effect of endosulfan which showed decrement of sperm count and testicular testosterone level in animals, was currently reported. The amount of endosulfan used as pesticide in the country has been continuously increased. The aim of this study was to suggest the permissible intake level (PIL), corresponding to Accept-able Daily Intake (ADI), based on endocrine disrupting effect wing BMD. Various animal data were collected by consideration of critical effect showing endocrine disruption and an animal data for reproductive toxicity was selected. The Power model from BMD software for induction of BMD/sub 10/o having meaning which is the dose at the 95% lower confidence limit on a 10％ response was used due to that the form of selected dose-response animal data was continuous data. The BMD/sub 10/ was estimated to be 0.393 mg/kg/day based on reproductive toxicity showing decrement of sperm count. The permissible intake level (PIL) was calculated by dividing the BMD/sub 10/ by the uncertainty factors of 100 with consideration of from animal to human and human variability. The PIL as 0.004 mg/kg/day was compared with traditional ADI as 0.006 mg/kg/day based on the incidence of marked progressive glomerulonephrosis and blood vessel aneurysm in males.

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기사명 저자명 페이지 원문 목차
3-Monochloro-1,2-propanediol(3-MCPD)의 안전성 및 위해성 평가 이병무 pp.1-11

Initial Risk Assessment of Acetanilide in OECD High Production Volume Chemical Program Hye-Youn Park 外著 pp.13-22

Initial Risk Assessment of Disodium Disulphite in OECD High Production Volume Chemical Program Sanghwan Song 外著 pp.23-29

A 4-week Repeated Oral Dose Toxicity Study of Plant Sterol Esters in Sprague-Dawley Rats Jong-Choon Kim 外著 pp.31-41

Case Report of Asbestos Exposure-Related Lung Carcinoma Hee Kyung Chang 外著 pp.43-46

1-(4-methylpiperazinyl)-3-phenylisoquinoline(CWJ-a-5)의 Sprague-Dawley(SD) 랫드를 이용한 2주간 반복 경구투여 독성시험 강부현 外著 pp.47-57

LNCaP 세포주를 이용한 내분비계장애물질중 안드로겐성 확인시험을 위한 검색법 김진호 外著 pp.59-64

생식독성과 Benchmark Dose를 활용한 Endosulfan의 노출허용수준 산출 이효민 外著 pp.65-71

마우스 및 랫드에서 자양강장제 황제공진보의 단회투여독성시험 이정남 外著 pp.73-77

YHB216의 토끼에서 국소독성시험 및 마우스에서 소핵시험 강민정 外著 pp.79-85

유전자 재조합 Human Factor Ⅷ(GC-γ AHF)의 안전성에 관한 연구 김민영 外著 pp.87-98
Di(2-ethylhexyl)phthalate의 발암위해성 평가 :MOE(Margin of Exposure) 방법론의 활용 최시내 外著 pp.99-106

참고문헌 (23건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 A new method for determining allowable daily intakes 미소장
2 Bioassay of endosulfan for possible carcinogenicity 미소장
3 (Reference title not available) 미소장
4 (Reference title not available) 미소장
5 Toxicological Profile for Endosulfan;Agency for Toxic Substances and Diease Registry 미소장
6 Dose-response assessment strategies for endocrine-active compounds 미소장
7 Involvement of picrotoxinin receptor in the action of cyclodiene insecticdes 미소장
8 (Reference title not available) 미소장
9 Endosulfan elevates testosterone biotransformation and clearance in CD-1 mice 미소장
10 Effects of endosulfan - technical (code HOE 02671 O I AT209) on reproductive function of multiple generation in rat 미소장
11 Biochemical changesin the testis of rats 미소장
12 Casarett and Doull's Toxicology 미소장
13 (Reference title not available) 미소장
14 (Reference title not available) 미소장
15 (Reference title not available) 미소장
16 Reproductive effects of endosulfan on male offspring of rats exposed during pregnancy and lactation 미소장
17 (Reference title not available) 미소장
18 Teratology study with FMC 5462 in rabbits. Conducted for Food Machinery and Chemical Corporation 미소장
19 Gonadal toxicity of short term chronic endosulfan exposure to male rats 미소장
20 (Reference title not available) 미소장
21 Chlorinated Hydrocarbon Insecticides 미소장
22 A review of the acceptable daily intakes of pesticides assessed by the World Health Organization 미소장
23 Effect of sub-chronic endosulfan exposures on plasma gonadotrophins, testosterone, testicular testosterone and enzymes of androgen biosynthesis in rat 미소장

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