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한국학술지인용색인(NRF)
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Objective : Surgically removed herniated lumbar disc specimen are immunostained to evaluate the production of
MMPs(Matrix metalloproteinases) -1,2,3 for the investigation of the possible correlation of MMPs in lumbar disc
herniation depending on the types of disc herniation.
Methods : The study population consists of 30 patients with lumbar disc herniation. There were 18 men and 12
women with patient age averaging 43.4 years(19-68years). The types of disc herniation identified at the time of
surgery were classified as follow ; protruded type(Group 1, 10cases), extruded type(Group 2, 10cases), sequestrated
type(Group 3, 10cases). Immunohistochemical study for the MMPs of the herniated disc tissue was performed and
results of staining were graded to examine differences in histology among three types of disc herniation .
Results : The MMPs immunopositive cells were increased in old patients but statistically it was not
significant(p=0.074). A significantly increased incidence of positive cells for MMP-1,2 was found in the herniated
lumbar disc tissue than the control group(p=0.02) but there were no significant differences among the three types
of disc herniation. The MMP-3 positive cells were predominantly detected in the sequestrated disc tissue
group(p=0.037) more than other groups.
Conclusion : These results suggest that the MMP-1,2,3 may play important roles in the process of degeneration,
herniation, and resorption of the lumbar intervertebral discs and that the MMP-3 may express the severity of lumbar
disc herniation and play a role in resorption of the sequestrated disc tissue.권호기사
참고문헌 (28건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Liw, (2003) The potentialand limitations of a cell-seeded collagen/hyaluronan scaffold to engineer anintervertebral disc-like matrix, | 미소장 |
| 2 | Roberts S, (1997) MatrixMetalloproteinases in the Human Intervertebral Disc:Role in DiscDegeneration and scoliosis, | 미소장 |
| 3 | Budet C, (1992) Lumbar disc herniation, | 미소장 |
| 4 | Gaudin P, (2001) Intervertebraldisk degeneration and herniation:the role of metalloproteinases andcytokines, | 미소장 |
| 5 | Goupille P, (1998) Matrix metalloproteinases :the clue to intervertebral disc degeneration?, | 미소장 |
| 6 | Hanley En Jr, (2003) Recent advances in disc cell biology, | 미소장 |
| 7 | Ishihara H, (1999) Effects ofhydrostatic pressure on matrix synthesis and matrix metalloproteinaseproduction in the human lumbar intervertebral disc, | 미소장 |
| 8 | Shinomiya K, (1999) Up-regulatedexpression of Matrilysin and Neutrophil collagenase in human herniateddisc, | 미소장 |
| 9 | Shinomiya K, (1996) Upregulated expression of chemokines in herniated nucleus pulposus.resorption, | 미소장 |
| 10 | Murakami S, (1997) Chemonucleolysis with human Stromelysin-1, | 미소장 |
| 11 | Shinomiya K, (1996) Upregulated expression of chemokines in herniated Nucleus Pulposusresorption, | 미소장 |
| 12 | Benjamin M, (2001) Extracellular matrix in developmentof the intervertebral disc, | 미소장 |
| 13 | Hukuda S, (1996) Immunohistochemicalstudy of Matrix Metalloproteinase-3 and Tissue inhibitor ofMetalloproteinase-1 in Human Inervertebral Discs, | 미소장 |
| 14 | Kang JD, (1996) Hernated lumbar intervertebral discsspontaneously produce matrix metalloproteinases, Nitric Oxid, Interleukin-6, and Prostaglandin E2, | 미소장 |
| 15 | Kang JD, (1997) Toward a biochemical understanding of human intervetebral discdegeneration and herniation, | 미소장 |
| 16 | Cho KH, (2000) Theroles of Matri metalloproteinases-1,2 in the degeneratvie spinal diseases, | 미소장 |
| 17 | Shinomiya K, (1996) TheNatural history of herniated nucleus pulposus with radiculopathy, | 미소장 |
| 18 | Marchetti C, (1999) Immunolocalization of gelatinase-A (matrixmetalloproteinase-2) in damaged human temporomandibular joint discs, | 미소장 |
| 19 | Maeda M, (1998) The involvement of MatrixMetalloproteinases and inflammation in Lumbar Disc Herniation, | 미소장 |
| 20 | Schleicher ED, (1997) Immunohistologic Markers forAge-related changes of human lumbar intervertebral discs, | 미소장 |
| 21 | Hirano N, (1993) Morphologicvariation of lumbar posterior longitudinal ligament and the modality of dischernation, | 미소장 |
| 22 | Masaaki Y, (1997) MatrixMetalloproteinase-3 production by human degenerated IntervertebralDisc, | 미소장 |
| 23 | Melrose J, (2001) Regulation of gelatinase-A(MMP-2) production by ovine intervertebral disc nucleus pulposus cellsgrown in alginate bead culture by Transforming Growth Factor-beta(1)andinsulin like growth factor-I, | 미소장 |
| 24 | Caterson B, (2000) Matrix Metalloproteinases and aggrecanase.Their role in disorders of the human intervetebral disc, | 미소장 |
| 25 | Menage J, (1991) Collagen typesaround the cells of the intervetebral disc and cartilage end plate:animmunolocalization study, | 미소장 |
| 26 | Melrose J, (2003) Induction of matrixmetalloproteinase-2 and -3 activity in ovine nucleus pulposus cells grownin three-dimensional agarose gel culture by interleukin-1beta:a potentialpathway of disc degeneration, | 미소장 |
| 27 | Haro H, (2001) The association of degeneration of the intervertebral disc with 5a/6apolymorphism in the promotor of the human matrix metalloproeinase-3 gene, | 미소장 |
| 28 | Nerlich AG, (2002) 2002 SSE AwardCompetition in Basic Science : expression of major matrix metalloproteinasesis associated with intervertebral disc degradation and resorption, | 미소장 |
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