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한국학술지인용색인(NRF)
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Background: Intravenous anesthetics causes depression of ventilatory response to hypercapnea. Doxapram stimulates ventilation via peripheral and central chemoreceptors. This study was aimed to evaluate the effect of doxapram on ventilation during total intravenous anesthesia (TIVA).
Methods: 60 patients undergoing operation under spontaneous ventilation via laryngeal mask airwaywere randomly divided into 3 groups: Control group received 5% dextrous infusion, D-2 group received doxapram injection of 1 mg/kg followed by continuous infusion of 2 mg/kg/hr, and D-4 group received doxapram injection of 2 mg/kg followed by continuous infusion of 4 mg/kg/hr. Anesthesia was induced and maintained with propofol and remifentanil. Respiratory rate, tidal volume (VT) and arterial carbon dioxide tension (PaCO2) were measured before and 15 min after induction of anesthesia, 0(15 min after start of operation), 1, 2, 3, 5, 15, 30, 45, and 60 min after start of doxapram infusion during TIVA.
Results: VT was significantly increased 1 min after start of doxapram infusion and returned to the value of pre-doxapram infusion immediately. In D-4 group, VT was significantly (P ＜ 0.05) increased again 5 min after doxapram infusion compared with the value of pre-doxapram infusion and control group. PaCO2 was decreased 1 min after start of doxapram infusion and then increased again 2 min after doxapram infusion. In D-4 group, the degree of increase of PaCO2 was significantly (P ＜ 0.05) less than those of D-2 group.
Conclusions: Doxapram injection of 2 mg/kg followed by continuous infusion of 4 mg/kg/hr improved the depression of ventilatory response during TIVA.권호기사
참고문헌 (29건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Longnecker DE, (1997) Introduction to Anesthesia. 9th ed, WB Saunders co | 미소장 |
| 2 | Miller RD, (2005) Anesthesia. 6th ed, Elsevier, Churchill Livingston | 미소장 |
| 3 | Prospective Comparison of Use of the Laryngeal Mask and Endotracheal Tube for Ambulatory Surgery  |
미소장 |
| 4 | Ventilatory effects of doxapram in conscious human subjects. |
미소장 |
| 5 | Doxapram improves pulmonary function after upper abdominal surgery. |
미소장 |
| 6 | (1998) Remifentanil in combination with propofol for spontaneous ventilation anesthesia, | 미소장 |
| 7 | (1997) A comparison of a combination of midazolam plus propofol and propofol alone, | 미소장 |
| 8 | ACUTE VENTILATORY CHANGES DURING I.V. INDUCTION OF ANAESTHESIA WITH THIOPENTONE OR PROPOFOL IN MAN |
미소장 |
| 9 | SOME VENTILATORY EFFECTS OF PROPOFOL AS SOLE ANAESTHETIC AGENT |
미소장 |
| 10 | (1996) Ventilatory parameters in children during propofol anaesthesia a comparison with halothane, | 미소장 |
| 11 | (2000) Intravenous opioid anesthetics, Philadelphia, Churchill-Livingstone | 미소장 |
| 12 | (2004) Remifentanil update: clinical science and utility, | 미소장 |
| 13 | Ventilatory effects of propofol during induction of anaesthesia. Comparison with thiopentone. |
미소장 |
| 14 | THE RESPIRATORY EFFECTS OF PROPOFOL WITH AND WITHOUT FENTANYL |
미소장 |
| 15 | (2003) Response surface modeling of remifentanil- propofol interaction on cardiorespiratory control and bispectral index, | 미소장 |
| 16 | (194-201) Regulation of respiration third of three parts, | 미소장 |
| 17 | (1997) Neuropharmacology of the control of ventilation, Philadelphia, Lippincott-Raven | 미소장 |
| 18 | Doxapram improves pulmonary function after upper abdominal surgery. |
미소장 |
| 19 | (2006) A new look at the respiratory stimulant doxapram, | 미소장 |
| 20 | Effect of doxapram on postoperative pulmonary complications after upper abdominal surgery in high-risk patients |
미소장 |
| 21 | EVIDENCE OF A ROLE FOR THE PERIPHERAL CHEMORECEPTORS IN THE VENTILATORY RESPONSE TO DOXAPRAM IN MAN |
미소장 |
| 22 | (1996) Use of the respiratory stimulant doxapram in southern elephant seals (Mirounga leonina), | 미소장 |
| 23 | (1996) The influence of alfentanil pre-treatment on ventilatory effects of doxapram followinginduction of ahaesthesia with propofol, | 미소장 |
| 24 | (1997) The effect of doxapram-induced hyperventilation on respiratory mechanics in horses, | 미소장 |
| 25 | (brjanaesth1994;73) Comparison of the effects of doxapram or carbon dioxide on ventilatory frequency and tidal volume during induction of anaesthesia with propofol, | 미소장 |
| 26 | (2006) Clinical observation of target- controlled remifentanil infusion combined with propofol and doxapram in painless artificial abortion, | 미소장 |
| 27 | The use of doxapram hydrochloride with inhalation anesthetics in horses, | 미소장 |
| 28 | (1997) Doxapram in hypercapnic chronic obstructive pulmonary disease with respiratory failure, | 미소장 |
| 29 | Doxapram infusion during halothane anaesthesia in ponies. |
미소장 |
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