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cardiac

arrest or as single or multiple occlusions of the intracranial or extracranial cerebral arteries.

1 Yamaguchi et al.2 has introduced a one-stage anterior approach to occlude the common

carotid arteries (CCAs) and vertebral arteries (VAs). Methods : We used a 2-stage anterior

approach for producing transient global ischemia by 4-vessel occlusion (4-VO). Four to five

days after electrocauterization of two VAs using the anterior neck approach, two CCAs were

clipped for 10 min under anesthesia. Aminoguanidine (100 mg/kg) was administered intraperitoneally

immediately after 4-VO, and then twice a day for three consecutive days. Cresyl violet

staining and immunohistochemical analysis for the expression of GFAP, CD11b, nitrotyrosine,

iNOS, and Bax were performed, using brain slices obtained from the rats that were sacrificed

1, 3, 5 and 7 days after reperfusion. Results : Aminoguanidine reduced neuronal cell

death in the CA1 region of the hippocampus. Expression of GFAP, CD11b, nitrotyrosine, iNOS,

and Bax were significantly increased in the CA1 region of the hippocampus three days after

4-VO. Conclusions : We believe that modified 4-VO is a good method to study transient forebrain

ischemia as it is simple and inexpensive to perform and can be utilized without stereotaxis,

a pivoting dissection microscope, EEG, a laser flowmeter or the use of Mongolian gerbils.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
대장암에서 cyclin-dependent kinase-associated protein phosphatase 단백의 발현 김창남 ;김수영 ;김재화 ;강동욱 ;손현진 ;이혜경 ;박미자 ;김주헌 pp.367-372

Juvenile ossifying fibroma :a clinicopathologic study of 8 cases and comparison with craniofacial fibro-osseous lesions Sohyung Park ;Bong-jae Lee ;Jeong Hyun Lee ;Kyung-ja Cho pp.373-379

난소 상피암에서 현미부수체 불안정성 분석 설미영 ;최경운 ;김지연 ;강현정 ;신동훈 ;김익두 ;최효선 ;서순정 pp.380-386

비소세포 폐암종의 상피성장인자 수용체 상태와 임상-병리학적 연관성 :단백 발현, 유전자 증폭 및 생존분석 이승구 ;최 진 ;장세진 pp.387-392

흰쥐의 4-혈관폐쇄를 위한 간단하고 저렴한 앞목접근법 :해마의 면역조직학적 변화와 aminoguanidine이 신경세포사에 미치는 영향에 대한 연구 안영준 ;최기용 ;강 구 ;김용석 ;이승구 ;정일영 ;김근우 pp.393-405

Giant retroperitoneal lipomatous angiomyolipoma simulating liposarcoma :a brief case report Dakeun Lee ;Joungho Han ;Sung Joo Kim ;Dongil Choi pp.406-408

식도의 거대섬유혈관용종 :1예 보고 황일선 ;노종렬 ;김용희 ;조경자 pp.409-411

원발성 침윤성 소엽암종으로 오진한 유방으로 전이된 갑상샘 수질암종 :1예 보고 이영석 ;안정석 ;김철환 ;염범우 ;최종상 ;채양석 pp.412-415

Malignant deciduoid mesothelioma :a case report Jung Uee Lee ;Bum Kyeong Kim ;Yoon Mee Kim ;Hae Joung Sul ;Kyung Bok Lee ;Hoi Young Lee pp.416-419

Borderline clear cell adenofibromatous tumors of the ovary :two case reports Heejeong Lee ;Tae Jung Kim ;Jeana Kim ;Eun Joo Seo ;Kyo Young Lee pp.420-423

Solid variant of mammary adenoid cystic carcinoma Ji Eun Kwon ;Yoon Hee Lee ;Ju Yeon Pyo ;Sang Kyum Kim ;Byeong-woo Park ;Woo-ick Yang pp.424-426

유방암 환자에게서 관찰된 cytokeratin 탐식 조직구에 의한 감시 림프절의 거짓전이 :1예 보고 최금하 ;차은정 ;최하나 ;문우성 pp.427-429

Adrenocortical carcinoma, myxoid variant :a case report Bomi Kim ;Sun Och Yoon ;Dong-il Kim ;Myung-cherl Kook ;Eun Kyung Hong pp.430-435

참고문헌 (28건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 A model of elobal forebrain ischemia / reperfusion in the awake rat Neurol Res 2002; 24: 97406. 미소장
2 One-Stage Anterior Approach for Four-Vessel Occlusion in Rat 네이버 미소장
3 Ischemic brain damage in rats following cardiac arrest using a long-term recovery model. J Cereb Blood Flow Metab 1985; 5:420-31. 미소장
4 Expression of c-fos, p53, Transforming Growth Factor-beta1 and Glial Fibrillary Acidic Protein in Hippocampus Following Transient Forebrain Ischemia in Mongolian Gerbil 소장
5 Redefining the boundaries of the hippocampal CA2 subfield in the mouse using gene expression and 3‐dimensional reconstruction 네이버 미소장
6 A new model of bilateral hemispheric ischemia in the unanesthetized rat. 네이버 미소장
7 The four-vessel occlusion rat model: method for complete occlusion of vertebral arteries and control of collateral circulation. 네이버 미소장
8 A new model of bilateral hemispheric ischemia in the rat--three vessel occlusion model. 네이버 미소장
9 A new methodfor producing temporary complete cerebral ischemia in rats. J Cereb Blood Flow Metab 1991; 11:949-56. 미소장
10 Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain 네이버 미소장
11 Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. 네이버 미소장
12 Expression of inducible nitric oxide synthase immunoreactivity in rat brain following chronic hypoxia: effect of aminoguanidine 네이버 미소장
13 Inhibition of nitric oxide production during global ischemia ameliorates ischemic damage of pyramidal neurons in the hippocampus. 네이버 미소장
14 Nitric Oxide Production in the CA1 Field of the Gerbil Hippocampus After Transient Forebrain Ischemia 네이버 미소장
15 Subacute but not acute generation of nitric oxide in focal cerebral ischemia. 네이버 미소장
16 Extensive peroxynitrite activity during progressive stages of central nervous system inflammation 네이버 미소장
17 Peroxynitrite formation within the central nervous system in active multiple sclerosis 네이버 미소장
18 Nitrotyrosine generation via inducible nitric oxide synthase in vascular wall in focal ischemia-reperfusion 네이버 미소장
19 Expression of Inducible Nitric Oxide Synthase and Nitrotyrosine in Multiple Sclerosis Lesions 네이버 미소장
20 Bcl-x(l) Bax interaction after transient global ischemia. 네이버 미소장
21 Upregulation of Bax protein levels in neurons following cerebral ischemia. J. Neurosci. 15:6364–6376, 195. 미소장
22 Bcl-Xshort is elevated following severe global ischemia in rat brains. 네이버 미소장
23 Astrocytes and stroke: networking for survival? Neurochem Res 2003; 28:293-305. 미소장
24 Astrocytic response in the rodent model of global cerebral ischemia and during reperfusion 네이버 미소장
25 Transient global brain hypoxia-ischemia in adult rats: Neuronal damage, glial proliferation, and alterations in inositol phospholipid hydrolysis 네이버 미소장
26 Microglia in cerebral ischemia: molecular actions and interactions 네이버 미소장
27 Quantitative morphological study of microglial cells in the ischemic rat brain using principal component analysis 네이버 미소장
28 Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats. 네이버 미소장