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방광의 요로상피암에서 Minichromosome Maintenance7 증식표지자의 발현과 임상적 의의 / 맹영희 ; 강현욱 ; 허정식 1
[요약] 1
서론 1
대상 및 방법 2
1. 연구 대상 2
2. 면역조직화학법 2
3. 결과 판독 및 통계 3
결과 3
1. MCM7 양성률과 조직학적 등급 및 병기와의 관계 3
2. Ki-67 양성률과 조직학적 등급 및 병기와의 관계 4
3. 재발률 분석 4
고찰 4
결론 5
REFERENCES 6
초록보기
Purpose: The antibodies for minichromosome maintenance(MCM) proteins have been reported as potential proliferative markers and prognostic indicators in various human malignancies. The present study examined the expression pattern of MCM proteins in bladder carcinomas, and we also evaluated their prognostic significance as well as their potential applicability as proliferation markers.
Materials and Methods: Immunohistochemistry for MCM7 and Ki-67 was performed on paraffin sections from 47 cases of bladder carcinoma. The MCM7 and Ki-67 expressions were quantified and then analysis was carried out for determining the association between the expressions of MCM7 and Ki-67 and the clinicopathological parameters.
Results: A significant correlation existed between the expression rate of MCM7 and the histological grade(p＜0.0001). The Ki-67 expression rate was significantly related to the tumor grade(p=0.002) and the pathological stage(p=0.011). On multivariate analysis, MCM7 was not found to be an independent prognostic factor for predicting the recurrence of bladder carcinoma.
Conclusions: The results suggest that MCM is a reliable proliferation marker, but not an independent predictive factor for recurrence of bladder carcinoma. (Korean J Urol 2008;49:12-17)권호기사
참고문헌 (25건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Progression and survival in transitional cell bladder cancer: a comparison of established prognostic factors, S-phase fraction and DNA ploidy  |
미소장 |
| 2 | Detection of P53 tumor-suppressor-gene protein in bladder tumors and prostate cancer: possible clinical implications. |
미소장 |
| 3 | Natural history of superficial bladder tumors: 10- to 20-year follow-up of treated patients. |
미소장 |
| 4 | Biologic Differences Between Noninvasive Papillary Urothelial Neoplasms of Low Malignant Potential and Low-Grade (Grade 1) Papillary Carcinomas of the Bladder |
미소장 |
| 5 | A SURVEILLANCE SCHEDULE FOR G1Ta BLADDER CANCER ALLOWING EFFICIENT USE OF CHECK CYSTOSCOPY AND SAFE DISCHARGE AT 5 YEARS BASED ON A 25-YEAR PROSPECTIVE DATABASE |
미소장 |
| 6 | Eukaryotic DNA replication: from pre-replication complex to initiation complex |
미소장 |
| 7 | Stability of the Replicative Mcm3 Protein in Proliferating and Differentiating Human Cells |
미소장 |
| 8 | HsMCM2/BM28: a novel proliferation marker for human tumors and normal tissues. |
미소장 |
| 9 | Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer. |
미소장 |
| 10 | Cell Proliferation of Human Bladder Tumors Determined by Brdurd and Ki-67 Immunostaining |
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| 11 | Molecular and Immunohistochemical Analysis of the Prognostic Value of Cell-Cycle Regulators in Urothelial Neoplasms of the Bladder |
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| 12 | Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. |
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| 13 | Prognostic value of Ki‐67 antigen and p53 protein in urinary bladder cancer: immunohistochemical analysis of radical cystectomy specimens |
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| 14 | Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade |
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| 15 | Replicative MCM7 protein as a proliferation marker in endometrial carcinoma: a tissue microarray and clinicopathological analysis |
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| 16 | Minichromosome maintenance protein 2 expression in normal kidney and renal cell carcinomas: relationship to tumor dormancy and potential clinical utility. |
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| 17 | MIB‐1 as a proliferative marker in transitional cell carcinoma of the bladder |
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| 18 | MCM proteins: DNA damage, mutagenesis and repair |
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| 19 | Pairwise Interactions of the Six Human MCM Protein Subunits |
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| 20 | DNA replication regulation protein Mcm7 as a marker of proliferation in prostate cancer. |
미소장 |
| 21 | Cell‐cycle‐dependent regulation of DNA replication and its relevance to cancer pathology |
미소장 |
| 22 | Cancer-associated expression of minichromosome maintenance 3 gene in several human cancers and its involvement in tumorigenesis. |
미소장 |
| 23 | Identification and characterization of a novel component of the human minichromosome maintenance complex. |
미소장 |
| 24 | Prognostic Value of MCM2 Immunoreactivity in Stage T1 Transitional Cell Carcinoma of the Bladder |
미소장 |
| 25 | Minichromosome maintenance proteins 2 and 5 expression in muscle-invasive urothelial cancer: a multivariate survival study including proliferation markers and cell cycle regulators | 미소장 |
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