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The Rheum palmatum L., a traditional medicine in Korea, was screened for their estrogenic activity in a recombinant yeast system with a human estrogen receptor (ER) expression plasmid and a reporter plasmid used in a previous study. The $EC_{50}$ values of the n-hexane, dichloromethane, ethyl acetate, n-butanol, and water fractions of the methanolic extract of R. palmatum in the yeast-based estrogenicity assay system were 0.145, 0.093, 0.125, 1.459, 2.853 μg/mL, respectively, with marked estrogenic activity in the dichloromethane fraction. Using an activity-guided fractionation approach, five known anthraquinones, chrysophanol (1), physcion (2), emodin (3), aloe-emodin (4) and rhein (5), were isolated from the dichloromethane fraction. Compound 3 had the highest estrogenic relative potency (RP, 17bestradiol = 1.00) $(6.3 \times 10^{-2})$, followed by compound 4 $(3.8 \times 10^{-3})$, compound 5 $(2.6 \times 10^{-4})$, and compound 1 $(2.1 \times 10^{-4})$. Also, compound 3 and fraction 3 (which contained compound 3) of the dichloromethane fraction of R. palmatum showed strong cytotoxicity in both ER-positive (MCF-7) and -negative (MDA-MB-231) breast cancer cell lines.

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기사명 저자명 페이지 원문 목차
Methylpiperate derivatives from piper longum and their inhibition of monoamine oxidase Seon A Lee ;Ji Sang Hwang ;Xiang Hua Han ;Chul Lee ;Min Hee Lee ;Sang Gil Choe ;Seong Su Hong ;Dongh pp.679-683

Intermedins A and B :new metabolites from schisandra propinqua var. intermedia Hong-mei Li ;Chun Lei ;Yong-ming Luo ;Xiao-nian Li ;Xiao-lei Li ;Jian-xin Pu ;San-yun Zhou ;Rong-tao pp.684-687

Synthesis of bicyclic amines and their activities against try-panosoma brucei rhodesiense and plasmodium falciparum K₁ Robert Weis ;Heinrich Berger ;Marcel Kaiser ;Reto Brun ;Robert Saf ;Werner Seebacher pp.688-697

Synthesis of bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates as antibacterial agents against VRSA Boon-ek Yingyongnarongkul ;Nuttapon Apiratikul ;Nuntana Aroonrerk ;Apichart Suksamrarn pp.698-704

Melatonin treatment against remote organ injury induced by renal ischemia reperfusion injury in diabetes mellitus Ersin Fadillioglu ;Zehra Kurcer ;Hakan Parlakpinar ;Mustafa Iraz ;Cebrail Gursul pp.705-712

Quercetin :further investigation of its antinociceptive properties and mechanisms of action Arnaldo Willain Filho ;Valdir Cechinel Filho ;Leonardo Olinger ;Márcia Maria de Souza pp.713-721

Anti-proliferative effects of estrogen receptor-modulating compounds isolated from rheum palmatum Se Chan Kang ;Chang Min Lee ;Eui Su Choung ;Jong Phil Bak ;Jong Jin Bae ;Hyun Sook Yoo ;Jong Hwan Kw pp.722-726

Involvement of NF-kB in the inhibitory actions of paltycarya strobilacea on the TNF-α-induced monocyte adhesion to colon epithelial cells and chemokine expression Dinesh Babu ;Jong Suk Lee ;Su-young Park ;Dinesh Thapa ;Mi Kyoung Choi ;Ah Ra Kim ;Young-joon Park ; pp.727-735

Anti-inflammatory activity of some potassium salts of N, N-disubstituted 4-aminoazobenzenesulfonic acids in rat adjuvant arthritis Maryte Kazemekaite ;Laima Leonaviciene ;Ruta Bradunaite ;Zita Staniulyte ;Algirdas Palaima ;Valdemar pp.736-741

Emodin-induced apoptosis in human breast cancer BCap-37 cells through the mitochondrial signaling pathway Zhiwei Huang ;Guichen Chen ;Ping Shi pp.742-748

Effects of mitochondrial inhibitors on cell viability in U937 monocytes under glucose deprivation Mijin Han ;Dong-soon Im pp.749-757

Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of salvia miltiorrhiza bunge Su Jin Jeon ;Kun Ho Son ;Yeong Shik Kim ;Yong Hwan Choi ;Hyun Pyo Kim pp.758-763

In vitro characterization of the enzymes involved in the metabolism of 1-furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound Sang Kyu Lee ;Ju Hyun Kim ;Young Min Seo ;Hye Chun Hwa Kim ;Mi Jeong Kang ;Hye Gwang Jeong ;Eung Seo pp.764-770

Quercetin inhalation inhibits the asthmatic responses by exposure to aerosolized-ovalbumin in conscious guinea-pigs Hee Moon ;Hyun Ho Choi ;Ji Yun Lee ;Hyo Jin Moon ;Sang Soo Sim ;Chang Jong Kim pp.771-778

Effect of proton beam on blood vessel formation in early developing zebrafish (Danio rerio) embryos Gun Hyuk Jang ;Ji-hong Ha ;Tae-lin Huh ;You Mie Lee pp.779-785

Inhibition of ERK and activation of p38 are involved in diallyl disulfide induced apoptosis of leukemia HL-60 cells Hui Tan ;Hui Ling ;Jie He ;Lan Yi ;Jianguo Zhou ;Min Lin ;Qi Su pp.786-793

Chemoprotective effects of hesperidin against genotoxicity induced by cyclophosphamide in mice bone marrow cells Amirhosein Ahmadi ;Seyed Jalal Hosseinimehr ;Farshad Naghshvar ;Ebrahim Hajir ;Mehran Ghahremani pp.794-797

Investigation of the relationship between in vitro and in vivo release behaviors of acamprosate from enteric-coated tablets Yun-seok Rhee ;Seok Park ;Tae-won Lee ;Chun-woong Park ;Tae-young Nam ;Tack-oon Oh ;Ji-woong Jeon ;D pp.798-804

Simultaneous determination of amphetamine-type stimulants and cannabinoids in fingernails by gas chromatography-mass spectrometry Jin Young Kim ;Jae Chul Cheong ;Min Kyoung Kim ;Jae Il Lee ;Moon Kyo In pp.805-813

Pharmacokinetic/pharmacodynamic modeling of the cardiovascular effects of beta blockers in humans In-hwan Baek ;Min-hyuk Yun ;Hwi-yeol Yun ;Kwang-il Kwon pp.814-821

참고문헌 (21건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Phyto-oestrogens and Western diseases. 네이버 미소장
2 Role of quinoids in estrogen carcinogenesis. 네이버 미소장
3 Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production 네이버 미소장
4 Estrogen receptors in human nontarget tissues: biological and clinical implications. 네이버 미소장
5 Colditz, G. A., (1995) The use of estrogens and progestins and the risk of breast cancer in postmenopausal women, J. Med 미소장
6 Cardiovascular disease in women. 네이버 미소장
7 Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture. 네이버 미소장
8 Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities 네이버 미소장
9 Koyama, M., (1998) Novel type of potential anticancer agents derived from chrysophanol and emodin, J. Med. Chem 미소장
10 大黃素在血清、藥材及中藥方劑中之高效層析定量 네이버 미소장
11 Liu, R., (2004) Preparative isolation and purification of hydroxyanthraquinones and cinnamic acid from the Chinese medicinal herb Rheum officinale Baill. by highspeed counter-current chromatography, J. Chromatography A 미소장
12 Palacios, S., (1999) Current perspectives on the benefits of HRT in menopausal women, Maturitas 미소장
13 Making Decisions About Hormone Replacement Therapy 네이버 미소장
14 Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. 네이버 미소장
15 Female sex steroid hormones: from receptors to networks to performance—actions on the sensorimotor system 네이버 미소장
16 Ultraviolet spectrum identification of emodin in rabbit plasma by HPLC and its pharmacokinetics application 네이버 미소장
17 Woods, H. F., (2002) Phytoestrogens and Health, Crown copyright 미소장
18 Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin. 네이버 미소장
19 Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties. 네이버 미소장
20 Zhou, X. M., (1998) Biochemical study of Chinese rhubarb XXII. Inhibitory effect of anthraquinone derivatives on sodium-potassium-ATPase of a rabbit renal medulla and their diuretic action, Acta Pharm. Sin 미소장
21 Isolation and inhibitory activity against ERK Phosphorylation of hydroxyanthraquinones from rhubarb 네이버 미소장

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