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A high-performance liquid chromatographic method was developed for the determination of macelignan in rat plasma and applied to the pharmacokinetic study of macelignan in rats.

Chromatographic separation was achieved on a conventional ODS column with the mobile phase of water: acetonitrile: methanol = 35:32.5:32.5 (v/v/v %). The flow rate of isocratic elution was 1 mL/min and peaks were detected at 240 nm. The limit of detection was 10 ng/mL and the limit of quantitation was 20 ng/mL. The calibration curve was linear over the concentration range of 50-5000 ng/mL. Intra-and inter-day precision for the assay over the concentration range was below 10 % and the accuracy ranged between 96.0-107% for intra-day and 98.8-114% for inter-day, respectively. The method was applied to the single dose pharmacokinetic study of macelignan in rats and the results showed that this HPLC method was adequate to support the in vivo pharmacokinetic study of macelignan.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells Phan Van Kiem ;Tran Hong Quang ;Tran Thu Huong ;Le Thi Hong Nhung ;Nguyen Xuan Cuong ;Chau Van Minh pp.823-829

A new lignan glycoside from the fruits of cornus kousa burg Dae-Young Lee ;Ki-Hyun Yoo ;In-Sik Chung ;Ji-Young Kim ;Dae-Kyun Chung ;Dae-Keun Kim ;Sung-Hoon Kim pp.830-833

Synthesis and hypnotic activities of N-Cbz-α-aminoglutarimi-dooxy carboxylate derivatives Aesun Byun ;Jin Yup Park ;Kyung Hee Moon ;Min Soo Park pp.834-837

Synthesis and anticonvulsant evaluation of 6-amino-1,4-oxazepane-3,5-dione derivatives Gitalee Sharma ;Jin Yup Park ;Min Soo Park pp.838-842

Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents Xiaojuan Pei ;Won Jun Choi ;Yu Min Kim ;Long Xuan Zhao ;Lak Shin Jeong pp.843-849

Inhibitors of bone resorption from Halenia corniculata Jin Zhang ;Mi-Jeong Ahn ;Qi Shi Sun ;Ki-Yoon Kim ;Yun Ha Hwang ;Jei Man Ryu ;Jinwoong Kim pp.850-855

Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production Bahar Tunctan ;Fariborz A. Yaghini ;Anne Estes ;Kafait U. Malik pp.856-865

Antifibrotic activity of diterpenes from biota orientalis leaves on hepatic stellate cells Mi Kyeong Lee ;Hyekyung Yang ;Jeong Seon Yoon ;Eun Ju Jeong ;Do Yoon Kim ;Na Ry Ha ;Sang Hyun Sung ; pp.866-871

Cytoprotective roles of senescence marker protein 30 against intracellular calcium elevation and oxidative stress Tae Gen Son ;So Jung Kim ;Keunho Kim ;Min-Sun Kim ;Hae Young Chung ;Jaewon Lee pp.872-877

HPLC determination of malondialdehyde in ECV304 cell culture medium for measuring the antioxidant effect of vitexin-4"-O-glucoside Xi-xiang Ying ;Hai-bo Li ;Zheng-yun Chu ;Yan-jun Zhai ;Ai-jing Leng ;Xun Liu ;Chun Xin ;Wen-jie Zhan pp.878-885

Anti-platelet effects of flavonoids and flavonoid-glycosides from sophora japonica Jeong Mi Kim ;Hye Sook Yun-Choi pp.886-890

Effects of calcium channel blockers on hyaluronidase-induced capillary vascular permeability Zekai Halici ;Halis Suleyman ;Elif Cadirci pp.891-899

Constituents of the flowers of Erigeron annuus with inhibitory activity on the formation of advanced glycation end products (AGEs) and aldose reductase Dae Sik Jang ;Nam Hee Yoo ;Yun Mi Lee ;Jeong Lim Yoo ;Young Sook Kim ;Jin Sook Kim pp.900-904

Hypochlorous acid-induced modulation of cellular redox status in HeLa cells Sin Young Park ;Seoung Woo Shin ;Su-Min Lee ;Jeen-Woo Park pp.905-910

In vitro/in vivo relationship of gabapentin from a sustained-release tablet formulation :a pharmacokinetic study in the beagle dog Yun-Seok Rhee ;Seok Park ;Tae-Won Lee ;Chun-Woong Park ;Tae-Young Nam ;Tack-Oon Oh ;Ji-Woong Jeon ;S pp.911-917

Prolonged antidiabetic effect of zinc-crystallized insulin loaded glycol chitosan nanoparticles in type 1 diabetic rats Hyung Gon Jo ;Kyung Hyun Min ;Tae Hwan Nam ;Seong Ju Na ;Jae Hyung Park ;Seo Young Jeong pp.918-923

Preparation and gene delivery of alkaline amino acids-based cationic liposomes Li Li ;Yu Nie ;Rong Zhu ;Sanjun Shi ;Kui Luo ;Bin He ;Yang Yang ;Junxiao Yang ;Zhongwei Gu pp.924-931

Preparation of carbopol/chitosan interpolymer complex as a controlled release tablet matrix :effect of complex formation medium on drug release characteristics Myung-Hak Lee ;Myung-Kwan Chun ;Hoo-Kyun Choi pp.932-937

The effect of coenzyme Q10 on the pharmacokinetic parameters of theophylline ; Bong Kyu Yoo Rengarajan Baskaran ; Srinivasan Shanmugam ; Santhoshkumar Nagayya-Sriraman ; Ju Hyun Kim ; Tae Chun Jeong ; Chul Soon Yong ; Han-Gon Choi pp.938-944

Determination of macelignan in rat plasma by high-performance liquid chromatography with ultraviolet detection Ming Ji Jin ;Kisoo Seo ;Ilho Ha ;Hyo-Kyung Han pp.945-949

참고문헌 (7건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans 네이버 미소장
2 Increase of caspase-3 activity by lignans from Machilus thunbergii in HL-60 cells. 네이버 미소장
3 Separation of Leucas aspera, a medicinal plant of Bangladesh, guided by prostaglandin inhibitory and antioxidant activities. 네이버 미소장
4 An update on bioactive plant lignans. 네이버 미소장
5 Dietary Lignans: Potential Role in Cancer Prevention 네이버 미소장
6 Chromatographic analysis of lignans 네이버 미소장
7 Phytochemistry 네이버 미소장

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