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Purpose: The standard treatment of locally advanced

nasopharyngeal cancer is a concurrent chemoradiotherapy

(CCRT), and cisplatin has been used as the most

popular chemotherapeutic agent. But many different

doses and schedules for cisplatin administration such as

daily, weekly and 3 week cycles have been proposed.

We compared and analyzed the tumor response, the

overall survival, the toxicity and the chemotherapy dose

intensity in the patients with locally advanced nasopharyngeal

cancer who were treated with CCRT.

Materials and Methods: We performed a retrospective

study on 55 patients with locally advanced nasopharyngeal

cancer, and they were treated with CCRT as a

front-line treatment from Jan 1996 to Jun 2007 at Kangnam

Saint Mary's Hospital.

Results: The patients had a median age of 53 years

(range: 19∼75 years). Of the total 55 patients, a 3-week

cycle of 100mg cisplatin was administered in 31 patients

and 30 mg weekly cisplatin was administered in 24

patients combined with radiotherapy. Twenty one patients

had a complete response and four patients had a

partial response for a response rate of 71.4% (95% CI:

59.5∼83.3) after CCRT and followed by adjuvant

chemotherapy. The complete response rates for the 30 mg and

100 mg cisplatin groups were 72.7% (95% CI: 54.9∼

90.5) and 54.2% (95% CI: 36.7∼71.7), respectively (p=

0.23). The duration of CCRT in the 100mg cisplatin group

was significantly longer than that of the 30mg cisplatin

group (11.1±2.9 weeks vs. 9.0±1.2 weeks, p= 0.003).

The major deviation group, which was defined as prolongation

of the radiotherapy duration for more than 2 weeks,

had a significantly lower objective response rate than did

the non-deviation group (56.3% vs 84.2%, respectively,

p= 0.002). The major severe toxicities were leucopenia

(49.1%), pharyngoesophagitis (49.1%), anorexia (43.6%),

nausea (41.8%) and vomiting (40%).

Conclusions: Weekly 30mg cisplatin-based CCRT is a

practical, feasible cisplatin schedule for the patients with

locally advanced nasopharyngeal cancer in regard to

decreasing the interruption of radiation treatment and

decreasing the treatment-related acute toxicities.

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Treatment outcome of cisplatin-based concurrent chemoradiotherapy in the patients with locally advanced nasopharyngeal cancer Tae Hee Kim ;Yoon Ho Ko ;Myung Ah Lee ;Bum-soo Kim ;So Ryoung Chung ;Ie Ryung Yoo ;Chan-kwon Jung ;Y pp.62-70

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A case of multiple intussusceptions in the small intestine caused by metastatic renal cell carcinoma Wan Kyu Eo ;Gou Young Kim ;Sung Il Choi pp.97-99

참고문헌 (24건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Wei WI, Sham JST. Nasopharyngeal carcinoma. Lancet. 2005; 365:2041-54. 미소장
2 Nasopharyngeal carcinoma: molecular biomarker discovery and progress 네이버 미소장
3 Nasopharyngeal carcinoma 네이버 미소장
4 Analysis of 1379 patients with nasopharyngeal carcinoma treated by radiation. 네이버 미소장
5 Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. 네이버 미소장
6 Concomitant chemoradiotherapy. 네이버 미소장
7 Treatment of locally advanced head and neck cancer: historical and critical review. 네이버 미소장
8 Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety. 네이버 미소장
9 Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: positive effect on overall and progression-free survival. 네이버 미소장
10 Baujat B, Audry H, Bourhis J, Chan AT. Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma (Review). 2007 The Cochrane Collaboration. 미소장
11 Kwong DL, Sham JS, Chua DT, Choy DT, Au GK, Wu PMl. The effect of interruptions and prolonged treatment time in radiotherapy for nasopharyngeal carcinoma. Int J Radiati Oncol Biol Phys. 1997;39:703-10. 미소장
12 Isobe K, Kawakami H, Uno T, Yasuda S, Aruga T, Ueno N, et al. Concurrent chemoradiotherapy for locally advanced nasopharyngeal carcinoma: is intergroup study 0099 feasible in Japanese patients? Jpn J Clin Oncol. 2003;33:497-500. 미소장
13 Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma: a factorial study. 네이버 미소장
14 Chitapanarux I, Lorvidhaya V, Kamnerdsupaphon P, Sumitsawan Y, Tharavichitkul E, Sukthomya V, et al. Chemoradiation comparing cisplatin versus carboplatin in locally advanced nasopharyngeal cancer: Randomized, non-inferiority, open trial. Eur J Cancer. 2007;43:1399-406. 미소장
15 Advances in nasopharyngeal carcinoma 네이버 미소장
16 RTOG acute radiation morbidity scoring criteria ＜http://www. rtog.org/ members/toxicity/acute.html>. 미소장
17 Long-term survival of nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy 네이버 미소장
18 Bahl M, Siu LL, Pond GR, Kim J, Tannock IF, Bayley A, et al. Tolerability of the Intergroup 0099 (INT 0099) regimen in locally advanced nasopharyngeal cancer with a focus on patients' nutritional status. Int J Radiat Oncol Biol Phys. 2004;60:1127-36. 미소장
19 Causes of interruption of radiotherapy in nasopharyngeal carcinoma patients in Taiwan. 네이버 미소장
20 Prognostic significance of keratinization in nasopharyngeal carcinoma 네이버 미소장
21 The national cancer data base report on the relationship of race and national origin to the histology of nasopharyngeal carcinoma 네이버 미소장
22 Prognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapy 네이버 미소장
23 Multicenter, phase II study of cetuximab in combination with carboplatin in patients with recurrent or metastatic nasopharyngeal carcinoma. 네이버 미소장
24 Hak Choy. Chemoradiation in cancer therapy. 1st ed. New Jersey: Humana Press; 2003. p. 9-50. 미소장

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