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Background: This study was designed to evaluate the effects of continuous infusion of ondansetron on postoperative nausea and vomiting (PONV) in patients receiving intravenous patient controlled analgesia (IV-PCA) following laparoscopic gynecological surgery.
Methods: Sixty ASA class I and II patients scheduled for gynecological laparoscopic surgery were randomly divided into the following 3 groups that received the specified dosages of ondansetron mixed with IV-PCA: placebo (group 1), ondansetron 8 mg (group 2), ondansetron 16 mg (group 3). The incidences of nausea, vomiting, visual analogue scale (VAS), and side effects were then recorded in the recovery room, 24 h, 48 h and 72 h postoperatively.
Results: There were no significant differences in the occurrence of nausea between group 1 and 2. However, the incidence of nausea in group 3 was significantly lower than in group 1 at 24 h and 48 h after surgery. In addition, significant differences in the occurrence of vomiting were observed among the three groups. However, with the exception of pruritus, no side effects were observed in any of the groups.
Conclusions: IV-PCA mixed with 16 mg of ondansetron effectively prevented nausea at 24 h and 48 h after gynecologic laparoscopic surgery.| 번호 | 참고문헌 | 국회도서관 소장유무 |
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| 1 | The Comparison of Effectiveness of Ondansetron and Droperidol on Antiemesis | 소장 |
| 2 | Macario A, Weinger M, Carney S, Kim A: Which clinical anesthesia outcomes are important to avoid? Anesth Analg 1999; 89: 652-8. | 미소장 |
| 3 | The Safety and Efficacy of Prophylactic Ondansetron in Patients Undergoing Modified Radical Mastectomy ![]() |
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| 4 | Prophylactic Antiemetic Efficacy of Ondansetron in Gynecologic Pelviscopic Patients | 소장 |
| 5 | Single dose intravenous ondansetron for the 24-hour treatment of postoperative nausea and vomiting. ![]() |
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| 6 | A Study on the Effect of Dosage Increase and Methods of Ondansetron Administration on the Prevention of Postoperative Nausea and Vomiting of Vaginal Total Hysterectomy Patients during IV Patient-Controlled Analgesia | 소장 |
| 7 | Du Pen S, Scuderi P, Wetchler B, Sung YF, Mingus M, Clayborn L, et al: Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study. Eur J Anaesthesiol 1992; 6: 55-62. | 미소장 |
| 8 | Comparison of Dexamethasone and Ondansetron for the Prevention of Nausea and Vomiting Using Intravenous Patient-Controlled Analgesia after Gynecologic Surgery ![]() |
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| 9 | Boonmak P, Boonmak S, Bunsaenqiaroen P, Srichaipanha S, Poomsawat S, Nonlhaopol D: Antiemetic effect of ondansetron 0.2mg mL−1 in PCA morphine solution. Eur J Anaesthesiol 2007; 24: 664-7. | 미소장 |
| 10 | The Effect of Continuous Infusion of Ondansetron on Nausea and Vomiting during Intravenous Patient-controlled Analgesia | 소장 |
| 11 | Alfentanil causes less postoperative nausea and vomiting than equipotent doses of fentanyl or sufentanil in outpatients. ![]() |
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| 12 | A survey of postoperative nausea and vomiting. ![]() |
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| 13 | Can postoperative nausea and vomiting be predicted? ![]() |
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| 14 | Apfel CC, Kranke P, Katz MH, Goepfert C, Papenfuss T, Rauch S, et al: Volatile anaesthetics may be the main cause of early but delayed postoperative vomiting: a randomized controlled trial of factorial design. Br J Anaesth 2002; 88: 659-68. | 미소장 |
| 15 | Postoperative Nausea and Vomiting ![]() |
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| 16 | Antiemetic Efficacy of Prophylactic Ondansetron in Gynecologic Patient Using Patient-Controlled Analgesia after Surgery | 소장 |
| 17 | Antiemetic efficacy of ondansetron with patient‐controlled analgesia ![]() |
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| 18 | Comparison of Dexamethasone and Ondansetron for the Prevention of Nausea and Vomiting Using Intravenous Patient-Controlled Analgesia after Gynecologic Surgery ![]() |
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| 19 | Ondansetron Reduces Postoperative Nausea and Vomiting after a Laparoscopic Cholecystectomy ![]() |
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| 20 | Vagal bradycardia produced by microinjections of morphine-like drugs into the nucleus ambiguus in anaesthetized dogs ![]() |
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| 21 | Alfentanil infusion for postoperative pain: a comparison of epidural and intravenous routes. ![]() |
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| 22 | Ventilatory effects during and after continuous infusion of fentanyl or alfentanil. ![]() |
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| 23 | Comparison of Postoperative Pain after Abdominal and Laparoscopic Assisted Vaginal Hysterectomy by using IV-PCA | 소장 |
| 24 | Kim DY, Kim CH, Lee CH: Effects of general, inhalation or balanced, anesthetic techniques on postoperative pain control using an iv-pca for hysterectomy. Korean J Anesthesiol 1998; 35: 504-10. | 미소장 |
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