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A liquid chromatography-electrospray ionization-tandem mass spectrometric (LC-ESI-MS/MS) method was developed and validated for the simultaneous detection and quantification of seven amphetamine derivatives (amphetamine (AP), methamphetamine (MA), 3,4-methylenedioxy-N-amphetamine (MDA), 3,4-methylenedioxy-N-methamphetamine (MDMA), 3,4-methylenedioxy-N-ethylamphetamine (MDEA), N,N-dimethylamphetamine (DMA), and N,N-dimethylamphetamine-N-oxide (DMANO)) in human urine. Seven deuterium-labeled compounds were prepared for use as internal standards to quantify the analytes. One milliliter of urine was combined with 1 mL of 0.2 M sodium carbonate buffer solution (pH 9.0) before solid phase extraction (SPE). An Oasis HLB SPE column followed by chromatographic separation on a Capcell Pak C18 MG-II column (150 × 2.0 mm I.D., 5 μm) and electrospray mass spectrometry with multiple reaction monitoring were used for selective and sensitive detection. The use of ammonium formate (5 mM, pH adjusted to 4.0 with formic acid, Solvent A) and acetonitrile (Solvent B) as the mobile phase at a flow rate of 230 μL/min was found to be the most effective for the separation. The linear ranges were 5.0-1000 ng/mL for AP, MDA, MDMA, MDEA, DMA, and DMANO and 10.0- 1000 ng/mL for MA, with good correlation coefficients (r² > 0.996). The intra-day, inter-day, and interperson precisions were within 14.6%, 12.1% and 15.5%, respectively. The intra-day, inter-day, and interperson accuracies were between -11.6 and 9.0%, -7.9 and 2.3%, and -13.2 and 4.3%, respectively. The limits of detection (LODs) for each analytical compound were lower than 1.95 ng/mL. The recovery ranged from 72.3 to 103.3%. The applicability of the developed method was examined by analyzing several urine samples from confirmed drug abusers.

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기사명 저자명 페이지 원문 목차
Bioactivities of polyphenolics from the roots of Bauhinia racemosa Renuka Jain ;Umesh Saxena ;Kiran Rathore ;Satish C. Jain pp.1525-1529

Two novel A-seco-rearranged lanostane triterpenoids from Abies sachalinensis Bohang Sun ;Bailing Hou ;Jian Huang ;Lijun Wu ;Masonori Kuroyanagi ;Huiyuan Gao pp.1530-1533

Osteogenic activities of genistein derivatives were influenced by the presence of prenyl group at ring A Yan Zhang ;Xiao-li Li ;Xin-sheng Yao ;Man-sau Wong pp.1534-1539

CoMFA on the melanogenesis inhibitory activity of alkyl-3,4-dihydroxybenzoate, N-alkyl-3,4-dihydroxybenzamide analogues, and prediction of higher active compounds Sang-jin Kim ;Pyung-keun Myung ;Nack-do Sung pp.1540-1546

Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia Hong-wen Tao ;Xiao-jiang Hao ;Pei-pei Liu ;Wei-ming Zhu pp.1547-1551

Inhibitory effect of hypochlorous acid on lower esophageal sphincter tone relaxation by vasoactive intestinal peptide Sun Young Park ;Ji Hyun Youm ;Kyoung Chul Jung ;Uy Dong Sohn pp.1552-1558

Concise synthesis of obovatol :chemoselective ortho-bromination of phenol and survey of Cu-catalyzed diaryl ether couplings Jae-hwan Kwak ;Jin-kyung In ;Mi-sung Lee ;Eun-hwa Choi ;Heesoon Lee ;Jin Tae Hong ;Yeo-pyo Yun ;Soo pp.1559-1563

Anti-hyperlipidemic effect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407 :induced hyperlipidemic and cholesterol-fed rats Na Young Yoon ;Hyeung Rak Kim ;Hae Young Chung ;Jae Sue Choi pp.1564-1571

Antitumor and antioxidant activity of protocatechualdehyde produced from Streptomyces lincolnensis M-20 Kyoung-ja Kim ;Mi-ae Kim ;Jee-hyung Jung pp.1572-1577

Triterpenoic acids of Prunella vulgaris var. lilacina and their cytotoxic activities in vitro Il Kyun Lee ;Do Hoon Kim ;Seung Young Lee ;Kyung Ran Kim ;Sang Un Choi ;Jong Ki Hong ;Jei Hyun Lee ; pp.1578-1583

Four-week administration of nimesulide, a cyclooxygenase-2 inhibitor, improves endothelial dysfunction in the hindlimb vasculature of streptozotocin-induced diabetic rats Aly M Abdelrahman ;Yousuf M Al Suleimani pp.1584-1589

Inhibitory effect of kefiran on ovalbumin-induced lung inflammation in a murine model of asthma Ok-kyoung Kwon ;Kyung-seop Ahn ;Mee-young Lee ;So-young Kim ;Bo-young Park ;Mi-kyoung Kim ;In-young pp.1590-1596

Anti-allergic activity of an ethanol extract from Salviae miltiorrhiza Ju Hye Yang ;Kun Ho Son ;Jong Keun Son ;Hyeun Wook Chang pp.1597-1603

Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cells Ji Won Lee ;Min Kyung Cho pp.1604-1612

Transport of mistletoe lectin by M cells in human intestinal follicle-associated epithelium (FAE) in vitro Su-yun Lyu ;Won-bong Park pp.1613-1621

Determination of propylthiouracil in pharmaceutical formulation by high-performance liquid-chromatography with a post-column iodine-azide reaction as a detection system Robert Zakrzewski pp.1622-1630

Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin Jun-shik Choi ;Keon Wook Kang pp.1631-1636

Formulation of a extended release tablet containing dexibuprofen Hong Gi Yi ;Moon Hyuk Chi ;Yong-il Kim ;Jong Soo Woo ;Eun-seok Park pp.1637-1643

Simultaneous determination of methamphetamine, 3,4-methylenedioxy-N-methylamphetamine, 3,4-methylenedioxy-N-ethylamphetamine, N,N-dimethylamphetamine, and their metabolites in urine by liquid chromatography-electrospray ionization Jin Young Kim ;Jae Chul Cheong ;Beom Jun Ko ;Sang Kyu Lee ;Hye Hyun Yoo ;Changbae Jin ;Moon Kyo In pp.1644-1651

Skin penetration and retention of L-ascorbic acid 2-phosphate using multilamellar vesicles Juno Yoo ;Srinivasan Shanmugam ;Chung-kil Song ;Dae-duk Kim ;Han-gon Choi ;Chul-soon Yong ;Jong-soo pp.1652-1658

참고문헌 (17건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Chromatographia and Its Scientific Future 네이버 미소장
2 Chromatographia’s new layout and website 네이버 미소장
3 Caldwell, J., The metabolism of amphetamines in mammals. Drug Metab. Rev., 5, 219-280 (1976). 미소장
4 Cheng, W. C., Mok, V. K., Chan, K. K., and Li, A. F., A rapid and convenient LC/MS method for routine identification of methamphetamine/dimethylamphetamine and their metabolites in urine. Forensic Sci. Int., 166, 1-7 (2007). 미소장
5 Cho, B. I., Methamphetamine abuse: epidemiologic issues and implications. In Miller, M. A. and Kozel, N. J. (Eds.). NIDA Research Monograph 115. US Department of Health and Human Services, Rockville, pp. 99-106 (1991). 미소장
6 Cody, J. T., Metabolic precursors to amphetamine and methamphetamine. Forensic Sci. Rev., 5, 109-127 (1993). 미소장
7 Determination of amphetamine and methamphetamine in urine by solid phase extraction and ion-pair liquid chromatography-electrospray-tandem mass spectrometry. 네이버 미소장
8 Pharmacology and toxicology of amphetamine and related designer drugs. 네이버 미소장
9 Simultaneous chiral determination of methamphetamine and its metabolites in urine by capillary electrophoresis-mass spectrometry. 네이버 미소장
10 The metabolism of dimethylamphetamine in rat and man. 네이버 미소장
11 The role of nitrogen oxidation in the excretion of drugs and foreign compounds. 네이버 미소장
12 Discrimination of Dimethylamphetamine and Methamphetamine Use: Simultaneous Determination of Dimethylamphetamine-N-Oxide and Other Metabolites in Urine by High-Performance Liquid Chromatography-Electrospray Ionization Mass Spectrometry 네이버 미소장
13 Simultaneous determination of psychotropic phenylalkylamine derivatives in human hair by gas chromatography/mass spectrometry 네이버 미소장
14 Sato, M., Hida, M., and Nagase, H., Analysis of dimethylamphetamine and its metabolites in human urine by liquid chromatography-electrospray ionization-mass spectrometry with direct sample injection. Forensic Sci. Int., 128, 146- 154 (2002). 미소장
15 Supreme Prosecutors' Office, Drug Trend Report. vol. 12, Seoul, (2007). 미소장
16 Supreme Prosecutors' Office, White Paper on Drug-Related Crimes. Seoul, pp. 95-122, (2004). 미소장
17 Behavioral effects of N-methylamphetamine and N,N-dimethylamphetamine in rats and squirrel monkeys. 네이버 미소장

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