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국회도서관 홈으로 정보검색 소장정보 검색

초록보기

The purpose of this study is to characterize canine mesenchymal stem cells (MSCs) derived from bone

marrow (BM) for use in research on the applications of stem cells in canine models of development, physiology, and

disease. BM was harvested antemortem by aspiration from the greater tubercle of the humerus of 30 normal beagle

dogs. Canine BM-derived MSCs were isolated according to methods developed for other species and were characterized

based on their morphology, growth traits, cell-surface antigen profiles, differentiation repertoire, immunocytochemistry

results, and neurotrophic factor expression in vitro. The canine MSCs exhibited a fibroblast-like morphology with a

polygonal or spindle-shaped appearance and long processes; further, their cell-surface antigen profiles were similar

to those of their counterparts in other species such as rodents and humans. The canine MSCs could differentiate into

osteocytes and neurons on incubation with appropriate induction media. RT-PCR analysis revealed that these cells

expressed NGF, bFGF, SDF-1, and VEGF. This study demonstrated that isolating canine MSCs from BM, stem-cell

technology can be applied to a large variety of organ dysfunctions caused by degenerative diseases and injuries in

dogs. Furthermore, our results indicated that canine MSCs constitutively secrete endogenous factors that enhance

neurogenesis and angiogenesis. Therefore, these cells are potentially useful for treating dogs affected with various

neurodegenerative diseases and spinal-cord injuries.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Evaluation for serological patterns and fecal viral shedding by hemagglutination inhibition test and real-time PCR in Korean CPV-2 isolates Hyeong-Sun Moon ;Joon-Seok Lee ;So-Jeong Nam ;Soon-Seek Yoon ;Moon-Il Kang ;Seok-Yong Jeoung ;Doo Ki pp.435-439

Effect of methylprednisolone sodium succinate on innate immune function of canine peripheral blood phagocytes Moo-Rim Park ;Ji-Houn Kang ;Mhan-Pyo Yang pp.440-446

PCR based detection of Helicobacter spp. in saliva, dental plaque, vomitus and feces of dogs Sung-Woo Ha ;Jong-Hyun Yoo ;Tae-Ho Chung ;Woo-Sung Jung ;Hwa-Young Youn ;Joon-Seok Chae ;Cheol-Yong pp.447-451

Effects of chitosan on kidney function in streptozotocin-induced diabetic mice Kwang-Won Sun ;Oh-Deog Kwon pp.452-457

Canine mesenchymal stem cells derived from bone marrow :isolation, characterization, multidifferentiation, and neurotrophic factor expression in vitro Dong-In Jung ;Jeongim Ha ;Ju-Won Kim ;Byeong-Teck Kang ;Jong-Hyun Yoo ;Chul Park ;Jong-Hwan Lee ;Hee pp.458-465

Effects of petrolatum and glycerin on acetone damaged canine skin barrier Won-Seok Oh ;Tae-Ho Oh pp.466-470

Therapeutic effect of aquapuncture with bee-venom for canine pyoderma Hyung-Kyou Jun ;Sang-Hun Kim ;Cristopher-Mun-Ho Kim ;Sung-Whan Cho ;Moo-Hyung Jun ;Myung-Jo You ;Duc pp.471-475

Clinical and clinicopathological findings of naturally occurring hyperadrenocorticism in dogs :a retrospective study of 17 cases Sang-Gil Kang ;Jong-Hyun Yoo ;Chul Park ;Hee-Myung Park pp.476-481

Ophthalmic findings in 547 Korean sapsaree dogs Je-Min Chae ;Won-Tae Kim ;Man-Bok Jeong ;Na-Young Yi ;Shin-Ae Park ;Se-Eun Kim ;Young-Woo Park ;Ji-H pp.482-487

Effects of injectable anesthetics on fluorescein retinal angiographic phases in dogs Jae-Young Jang ;Young-Sam Kim ;Won-Tae Kim ;Chang-Su Jung ;Hyun-Ah Kim ;Min-Su Kim ;Na-Young Yi ;Man pp.488-493

The effects of hyaluronic acid-carboxymethylcellulose membrane (GUARDIX-MB^® ^) barriers on prevention of post-operation peritoneal adhesions in dogs Sang-Mook Lee ;Hwan-Soo Jang ;Jae-Sung Bae ;Jung-Eun Kim ;Kwang-Ho Jang pp.494-500

Estimation of gestational age by measurement of fetal and extra-fetal structures in Miniature Schnauzer bitches Bang-Sil Kim ;Chang-Ho Son pp.501-505

Bilateral congenital deafness in a white bull terrier :brainstem auditory evoked response findings Byeong-Teck Kang ;So-Young Lee ;Dong-In Jung ;Hyung-Joong Kim ;Eung-Je Woo ;Hee-Myung Park pp.506-509

Acute hepatic failure induced by xylitol toxicosis in two dogs Chae-Young Lim ;Jong-Hyun Yoo ;Chun-Geun Kim ;Chul Park ;Hee-Myung Park pp.510-513

Long-term chemotherapy with hydroxyurea in a dog with suspected intracranial meningioma Dong-In Jung ;Chae-Young Lim ;Byeong-Teck Kang ;Ju-Won Kim ;Jong-Hyun Yoo ;Hee-Myung Park pp.514-517

Cor triatriatum sinistrum with an ostium primum atrial septal defect in a siamese cat Ran Choi ;Changbaig Hyun pp.518-522

Sertoli cell tumor accompanied by pancytopenia in a dog Ul-Soo Choi ;Hyun-Wook Kim ;Ji-Hye Choi ;Hye-Jin Kim ;Jae-Young Jang ;Chang-Woo Lee pp.523-525

Alternative treatment for facial nerve paralysis in a dog Hassan Abdel-Rahman Abdel-Rahman ;Hyung-Kyou Jun ;Kun-Ho Song ;Jun-Gu Kang ;Duck-Hwan Kim pp.526-528

Duration of regain of deep pain perception after decompression surgery as a parameter of surgical outcome for acute thoracolumbar disc herniation hansen type Ⅰ with loss of deep pain perception in dogs Sung-Su Park ;Ji-Hey Lim ;Ye-Eun Byeon ;Byung-Jun Jang ;Hak-Hyun Ryu ;Ji-Yong Uhm ;Byung-Jae Kang ;W pp.529-532

Carnassial abscess following cellulitis complication in a young Maltese Joong-Hyun Kim ;Kirae Cho ;Tae Sung Han ;Seong Soo Kang ;Gonhyung Kim ;Seok Hwa Choi pp.533-536

Ununited anconeal process in a labrador retriever dog Jae-Hoon Lee ;Wo-Jong Yang ;Eun-Hee Kang ;Hwa-Seok Chang ;Dai-Jung Chung ;Chi-Bong Choi ;Jeong-Ik Le pp.537-539

Belt loop and circumcostal gastropexy techniques of canine gastric dilatation-volvulus :4 cases Jae-Hoon Lee ;Young-Su Lee ;Wo-Jong Yang ;Dai-Jung Chung ;Eun-Hee Kang ;Hwa-Seok Chang ;Chi-Bong Cho pp.540-544

Surgical reconstruction of the severe tongue laceration with mandibular fracture in a Siberian Husky dog Jae-Hoon Lee ;Tae-Hoon Kim ;Wo-Jong Yang ;Eun-Hee Kang ;Hwa-Seok Chang ;Dai-Jung Chung ;Chi-Bong Cho pp.545-548

Ileocecocolic and colocolic intussusception in a young Jindo Joo-Hyun Jung ;Woong-Joo Chae ;Do-Hyoung Kwon ;Jin-Hwa Chang ;Sun-Kyoung Oh ;Jung-Hee Yoon ;Min-Cheo pp.549-552

Radiographic features of traumatically caused retroflexion of urinary bladder in two dogs Haebeom Lee ;Hyewon Kang ;Min-su Kim ;Namsoo Kim ;Kichang Lee pp.553-556

Radiographic diagnosis of hypospadias in three Korean native calves Won-Seok Jeong ;Yun-Sang Seong ;In-Su Kim ;Hwan-Soo Jang ;Tae-Ho Oh ;Keun-Woo Lee ;Kwang-Ho Jang pp.557-559

참고문헌 (19건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Use of alkaline phosphatase staining to differentiate canine osteosarcoma from other vimentin-positive tumors. 네이버 미소장
2 Choi BH, Huh JY, Park DJ, Kim BY, Lee SHR, Park SY. Differentiation of adult canine bone marrow stem cells into neurons. J Kor Oral Maxillofac Surg 2003; 29: 1-4. 미소장
3 Analysis of neuron-like differentiation of human bone marrow mesenchymal stem cells 네이버 미소장
4 In Vitro Differentiation of Human Marrow Stromal Cells into Early Progenitors of Neural Cells by Conditions That Increase Intracellular Cyclic AMP 네이버 미소장
5 A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate. 네이버 미소장
6 Kadiyala S, Young RG, Thiede MA, Brauder SP. Culture expanded canine mesenchymal stem cells possess osteo-6: 125-134. 미소장
7 Expression of neural markers on bone marrow-derived canine mesenchymal stem cells. 네이버 미소장
8 Autologous adipose tissue-derived stromal cells for treatment of spinal cord injury. 네이버 미소장
9 Differentiating characterization of human umbilical cord blood-derived mesenchymal stem cells in vitro 네이버 미소장
10 Differentiation of functional dendritic cells and macrophages from human peripheral blood monocyte precursors is dependent on expression of p21 (WAF1/CIP1) and requires iron. 네이버 미소장
11 Mesenchymal Stem Cells and Bone Regeneration 네이버 미소장
12 Differentiation and isolation of hepatic-like cells from human embryonic stem cells 네이버 미소장
13 Neural differentiation of human mesenchymal stem cells: Evidence for expression of neural markers and eag K+ channel types. 네이버 미소장
14 Isolation and characterization of multipotential mesenchymal stem cells from feline bone marrow. 네이버 미소장
15 In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord blood. 소장
16 Quantification of bone alkaline phosphatase in canine serum. 네이버 미소장
17 Intracerebral peripheral blood stem cell (CD34+) implantation induces neuroplasticity by enhancing beta1 integrin-mediated angiogenesis in chronic stroke rats. 네이버 미소장
18 Effects of osteogenic inducers on cultures of canine mesenchymal stem cells. 네이버 미소장
19 Adult rat and human bone marrow stromal cells differentiate into neurons 네이버 미소장