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Some C-benzylated flavonoids based on gericudranin A were synthesized and evaluated their cytotoxic activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules in 6~7 steps via sequential protection, aldol condensation, cyclization, regioselective C-benzylation, and deprotection. The cellular growth inhibition of the synthetic C-benzylated flavonoids was investigated against sixteen human cancer cell lines. Among these compounds, 5b showed the most potent cytotoxicities against several cell lines, especially as potent as adriamycin against SNB19 cell lines with an IC50 value of 0.7 μM.

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기사명 저자명 페이지 원문 목차
Aporphine alkaloids from Clematis parviloba and their antifungal activity Jia-Hui Chen ;Zhi-Zhi Du ;Yue-Mao Shen ;Yong-Ping Yang pp.3-5

Anti-inflammatory phenylpropanoid glycosides from Clerodendron trichotomum leaves Kyoung Hee Kim ;Sungun Kim ;Min Young Jung ;In Hye Ham ;Wan Kyunn Whang pp.7-13

Structure-activity relationship studies of novel oxygen-incorporated SAHA analogues Soon-Ai Kim ;Ying Lan Jin ;Hak Sung Kim pp.15-21

Synthesis of 2-substituted-6-(4H-1,2,4-triazol-4-yl)benzo[d]oxazoles as potential anticonvulsant agents Cheng-Xi Wei ;Li-Ping Guan ;Jing-Hao Jia ;Kyu-Yun Chai ;Zhe-Shan Quan pp.23-31

Synthesis and antimicrobial activity of 1-benzhydryl-sulfonyl-4-(3-(Piperidin-4-yl)propyl)piperidine derivatives against pathogens of Lycopersicon esculentum :a structure-activity evaluation study K. Vinaya ;R. Kavitha ;C. S. Ananda Kumar ;S. B. Benaka Prasad ;S. Chandrappa ;S. A. Deepak ;S. Nanj pp.33-41

Diacylglycerol acyltransferase-inhibitory compounds from Erythrina senegalensis Won Keun Oh ;Chul- Ho Lee ;Jee Hee Seo ;Mi Yeon Chung ;Long Cui ;Z. Tanee Fomum ;Jong Seong Kang ;Hy pp.43-47

Anti-androgen-independent prostate cancer effects of ginsenoside metabolites in vitro :mechanism and possible structure-activity relationship investigation Wei Li ;Yong Liu ;Jiang-Wei Zhang ;Chun-Zhi Ai ;Nan Xiang ;Hui-Xin Liu ;Ling Yang pp.49-57

Synthesis and cytotoxic activities of C-benzylated flavonoids Yoon-Jung Choi ;Hwan Mook Kim ;Hee Doo Kim pp.59-63

The inhibitory effects of cholalic acid and hyodeoxycholalic aicd on the expression of TNFα and IL-1β after cerebral ischemia in rats Qian Hua ;Xiao-lei Zhu ;Peng-tao Li ;Yuan Liu ;Na Zhang ;Ya Xu ;Xu Jia pp.65-73

In vitro anti-inflammatory activity of carvacrol :inhibitory effect on COX-2 catalyzed prostaglandin E₂ biosynthesis Premysl Landa ;Ladislav Kokoska ;Marie Pribylova ;Tomas Vanek ;Petr Marsik pp.75-78

YL-Ⅰ-108, a synthetic chalcone derivative, inhibits lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 murine macrophages :involvement of heme oxygenase-1 induction and blockade of activator protein-1 Pil-Hoon Park ;Hak Sung Kim ;Jin Hur ;Xing Yu Jin ;Ying Lan Jin ;Dong Hwan Sohn pp.79-89

Inhibitory Effects of an aqueous extract of Cornus kousa Burg. leaves on TNF-α-induced chemokine expression and monocyte adhesion to human colonic epithelial cells Dinesh Babu ;Dinesh Thapa ;Jong Suk Lee ;Su-Young Park ;Ah Ra Kim ;Young Heui Kim ;Hong Chul Yang ;J pp.91-98

NS398 protects cells from sodium nitroprusside-mediated cytotoxicity through enhancing HO-1 induction independent of COX-2 inhibition Irina Tsoy Nizamutdinova ;Jae Heun Lee ;Han Geuk Seo ;Ki Churl Chang ;Hye Jung Kim pp.99-107

Protection against amyloid beta cytotoxicity by sulforaphane :role of the proteasome Hyun-Min Park ;Jung-Ae Kim ;Mi-Kyoung Kwak pp.109-115

Biological characterization of long-term cultured human mesenchymal stem cells Jiseon Kim ;Jin Wook Kang ;Jae Hyun Park ;Youngju Choi ;Kyung Suk Choi ;Ki Dae Park ;Dae Hyun Baek ; pp.117-126

Development of nifedipine-loaded coated gelatin microcapsule as a long acting oral delivery Dong Xun Li ;Jong Oh Kim ;Dong Hoon Oh ;Won Seok Lee ;Myung Ja Hong ;Jin Yang Kang ;Jong Seo Choi ;J pp.127-132

Enhanced bioavailability of etoposide after oral or intravenous administration of etoposide with kaempferol in rats Cheng Li ;Xiuguo Li ;Jun-Shik Choi pp.133-138

Toxicity studies of cremophor-free paclitaxel solid dispersion formulated by a supercritical antisolvent process Jae-Hyun Park ;Sang-Cheol Chi ;Won Seok Lee ;Won Mo Lee ;Yoon Bon Koo ;Chul Soon Yong ;Han Gon Choi pp.139-148

Pharmacokinetics of (-)-epicatechin in rabbits Yen-An Chen ;Kuang-Yang Hsu pp.149-154

Dihydroartemisinin-cyclodextrin complexation :solubility and stability Muhammad Tayyab Ansari ;Ijaz Iqbal ;Vivian Bruce Sunderland pp.155-165

참고문헌 (12건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Total Synthesis of (±)-Gericudranin A 네이버 미소장
2 Uvaretin, a new antitumor agent from Uvaria acuminata (Annonaceae). 네이버 미소장
3 Harborne, J. B., The Flavonoids: Advance in Research since 1980, Chapman and Hall, London (1988). 미소장
4 Uvaretin and isouvaretin. Two novel cytotoxic c-benzylflavanones from uvaria chamae L. 네이버 미소장
5 Uvarinol: a novel cytotoxic tribenzylated flavanone from Uvaria chamae 네이버 미소장
6 New Dihydrochalcones and Flavanones From Uvaria Angolensis 네이버 미소장
7 Cytotoxic C-Benzylated Dihydrochalcones from Uvaria acuminata 네이버 미소장
8 Two Benzylated Dihydroflavonols from Cudrania Tricuspidata 네이버 미소장
9 Cytotoxic benzyl dihydroflavonols from Cudrania tricuspidata 네이버 미소장
10 Induction of Apoptosis in Human Promyelocytic Leukemia Cell Line HL-60 by C-Benzylated Dihydrochalcones, Uvaretin, Isouvaretin and Diuvaretin(Medicinal Chemistry) 네이버 미소장
11 Skehan, P., Storeng, R., Scudiero, D., Monks, A., MaMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenny, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer- drug screening. J. Natl. Cancer Inst., 82, 1107-1112 (1990). 미소장
12 Wirasathien, L., Pengsuparp, T., Moriyasu, M., Kawanish, K., and Suttisri, R., Cytotoxic C-benzylated chalcone and other constituents of Ellipeiopsis cherrevensis. Arch. Pharm. Res., 29, 497-502 (2006). 미소장

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