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As a part of an ongoing project searching for new skin-lightening agents, the inhibitory property of 6- (3-Hydroxyphenyl)-2-naphthol (HPN) on melanogenesis was investigated. The inhibitory action of HPN (IC50=15.2 μM) on mushroom tyrosinase was revealed. To further explore the action of HPN on melanogenesis, the inhibition of tyrosinase and melanin levels were measured in B16 melanoma cells (B16 cells). Results show that HPN inhibited tyrosinase activity and reduced melanin in B16 cells. Therefore, our data indicate HPN as a new candidate for depigmentation reagents.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Synthesis and nuclear factor-kB inhibitory activities of 6- or 7-methylchroman-2-carboxylic acid N-(substituted) phenylamides Jae-Hwan Kwak ;Sun-Woo Won ;Tae-Jeong Kim ;Wonhui Yi ;Eun-Hwa Choi ;Seung-Chan Kim ;Hyunjeong Park ; pp.167-175

Stilbenes and oligostilbenes from leaf and stem of Vitis amurensis and their cytotoxic activity Do Thi Ha ;Quan Cheng Chen ;Tran Manh Hung ;Ui Joung Youn ;Tran Minh Ngoc ;Phuong Thien Thuong ;Hong pp.177-183

Immunosuppressive effects of new cyclolanostane triterpene diglycosides from the aerial part of Cimicifuga foetida Rui-Le Pan ;Di-Hua Chen ;Jian-Yong Si ;Xiao-Hong Zhao ;Zhan Li ;Li Cao pp.185-190

An oxepinoflavone from Artocarpus elasticus with cytotoxic activity against P-388 cells Iqbal Musthapa ;Lia D. Juliawaty ;Yana M. Syah ;Euis H. Hakim ;Jalifah Latip ;Emilio L. Ghisalberti pp.191-194

Antioxidant activities of new flavonoids from Cudrania tricuspidata root bark Young Jae Lee ;Sungun Kim ;Seung Jae Lee ;Inhye Ham ;Wan Kyunn Whang pp.195-200

Simultaneous determination of quercetin and its glycosides from the leaves of Nelumbo nucifera by reversed-phase high-performance liquid chromatography Hyun Ryul Goo ;Jae Sue Choi ;Dong Hee Na pp.201-206

Antioxidative iridoid glycosides and phenolic compounds from Veronica peregrina Jong Hwan Kwak ;Hyun Jung Kim ;Kwang Ho Lee ;Se Chan Kang ;Ok Pyo Zee pp.207-213

Graft preconditioning with low-dose tacrolimus (FK506) and nitric oxide inhibitor aminoguanidine (AGH) reduces ischemia/reperfusion injury after liver transplantation in the rat Norbert Hüser ;Dietrich Doll ;Jennifer Altomonte ;Martin Werner ;Monika Kriner ;Anne Preissel ;Stef pp.215-220

Antioxidative and hepatoprotective effects of magnolol on acetaminophen-induced liver damage in rats Yung-Hsiang Chen ;Feng-Yen Lin ;Po-Len Liu ;Yi-Tsau Huang ;Jen-Hwey Chiu ;Yi-Chun Chang ;Kee-Ming Ma pp.221-228

Ameliorating effect of capsaicin on alterations in lipid metabolism during mice lung carcinoma P. Anandakumar ;S. Jagan ;S. Kamaraj ;G. Ramakrishnan ;J. Binu Clara ;D. Pathitha ;T. Kavitha ;T. De pp.229-234

Safety assessment of chromium by exposure from cosmetic products Myungsil Hwang ;Eun Kyung Yoon ;Ja Young Kim ;Bo Kyung Son ;Seong Jun Yang ;Mi Ok Yun ;Sang Sook Cho pp.235-241

Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis Sule Gok ;Ahenk Izanli-Paksoy ;Kamil Vural pp.243-250

Interspecies scaling of oleanolic acid in mice, rats, rabbits and dogs and prediction of human pharmacokinetics Hye Young Ji ;Beom Soo Shin ;Dong Won Jeong ;Eun Jeong Park ;Eun-Seok Park ;Sun Dong Yoo ;Hye Suk Le pp.251-257

Effects of drying methods on the physicochemical and compressional characteristics of Okra powder and the release properties of its metronidazole tablet formulation L. G. Bakre ;K. T. Jaiyeoba pp.259-267

Effect of CYP2C9^*^3 allele on the pharmacokinetics of naproxen in Korean subjects Jung-Woo Bae ;Ji-Hong Kim ;Chang-Ik Choi ;Mi-Jeong Kim ;Hyung-Ji Kim ;Seong-Ae Byun ;Young-Soon Chan pp.269-273

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Comparison of peroxyl radical scavenging capacity of commonly consumed beverages Do Young Kwon ;Kwon Hui Choi ;Sun Ju Kim ;Dal Woong Choi ;Yeong Shik Kim ;Young Chul Kim pp.283-287

Inhibitory effects of 6-(3-hydroxyphenyl)-2-naphthol on tyrosinase activity and melanin synthesis Sang Woon Chung ;Young Mi Ha ;You Jung Kim ;Suhee Song ;Hyojin Lee ;Hongsuk Suh ;Hae Young Chung pp.289-294

Diacylglycerol Acyltransferase-Inhibitory Compounds from Erythrina senegalensis 오원균, 이철호, 서지희, 정미연, Long Cui, Tanee Fomum, 강종석 pp.295-295

참고문헌 (24건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Inhibition of skin pigmentation by an extract of Lepidium apetalum and its possible implication in IL-6 mediated signaling. 네이버 미소장
2 Im, S., Kim., J., On, W. Y., and Kang, W. H., Increased expression of alpha-melanocyte-stimulating hormone in the lesional skin of melasma. Br. J. Dermatol, 46, 165-167, (2002). 미소장
3 Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase. 네이버 미소장
4 Evidence of the indirect formation of the catecholic intermediate substrate responsible for the autoactivation kinetics of tyrosinase. 네이버 미소장
5 Treatment of Melasma Using Kojic Acid in a Gel Containing Hydroquinone and Glycolic Acid 네이버 미소장
6 Maeda, K. and Fukuda, M., Arbutin: mechanism of its depigmenting action in human melanocyte culture. J. Pharmacol. Exp. The., 276, 65-769 (1996). 미소장
7 Biotechnology: Promethean Science or Obsession? 네이버 미소장
8 Inhibitory Effects of Active Compounds Isolated from Safflower (Carthamus tinctorius L.) Seeds for Melanogenesis 네이버 미소장
9 Inhibition of tyrosinase by protocatechuic aldehyde. 네이버 미소장
10 Biotechnology and bioeconomy in China. 네이버 미소장
11 4,4'-Dihydroxybiphenyl as a New Potent Tyrosinase Inhibitor(Miscellaneous) 네이버 미소장
12 Effects of hydroxystilbene derivatives on tyrosinase activity 네이버 미소장
13 Oxyresveratrol and hydroxystilbene compounds. Inhibitory effect on tyrosinase and mechanism of action. 네이버 미소장
14 Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells. 네이버 미소장
15 Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. 네이버 미소장
16 Lee, H. J., Synthesis and biological evaluations of oxyresveratrol derivatives as whitening agents and antioxidants. MS degree Thesis. Pusan National University., pp.16-17 (2006). 미소장
17 Enzymatic control of pigmentation in mammals. 네이버 미소장
18 BMP-2 stimulates tyrosinase gene expression and melanogenesis in differentiated melanocytes. 네이버 미소장
19 Tada, H., Shiho, O., Kuroshima, K., Koyama, M., and Tsukamoto, K. J., An improved colorimetric assay for interleukin 2. Immunol. Methods, 93, 157-165 (1986). 미소장
20 Production of reactive oxygen by mitochondria from normoxic and hypoxic rat heart tissue 네이버 미소장
21 Enhancement of tyrosinase inhibition of the extract of Veratrum patulum using cellulase. 네이버 미소장
22 4-(6-Hydroxy-2-naphthyl)-1,3-bezendiol : A Potent, New Tyrosinase Inhibitor 네이버 미소장
23 alpha-MSH and the regulation of melanocyte function. 네이버 미소장
24 Kim, Y. J., Kang, K. S., and Yokozawa, T., The anti-melanogenic effect of pycnogenol by its anti-oxidative actions. Food Chem. Toxicol., 46, 2466-2471 (2008). 미소장