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Purpose: The study was to assess I-123-N-(3-iodopropen-2-yl)-2[beta]-carbomethoxy-3[beta]-(4-cholorophenyl) tropane (IPT) SPECT in differential diagnosis among early stage of Parkinson’s disease(PD) and essential tremor(ET) and normal control(NL) groups quantitatively. Materials and Methods: I-123 IPT brain SPECT of 50 NL, 20 early PD, 30 advanced PD, and 20 ET were performed at 20 minutes and 2 hours. Specific/nonspecific binding of striatum was calculated by using right and left striatal specific to occipital non-specific uptake ratio (striatum-OCC/OCC). Results: Mean value of specific/nonspecific binding ratio was significantly different between advanced PD group and NL group. However, significant overlap of striatal specific/nonspecific binding ratio was observed between PD group and ET group. Bilateral striatal specific/nonspecific binding ratios were decreased in advanced PD. Lateralized differences in the striatal uptake of I-123 IPT correlated with asymmetry in clinical findings in PD group. Conclusion: I-123 IPT SPECT may be a useful method for the diagnosis of PD and objective evaluation of progress of clinical stages. Care should be made in the differential diagnosis of early stage of PD and other motor disturbances mimicking PD such as ET in view of significant overlap in striatal I-123 specific/nonspecific binding ratio.

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기사명 저자명 페이지 원문 목차
^18^F-플루오린 표지를 위한 신개념 반응용매에서 친핵성 불소화 반응 김동욱 ;정환정 ;임석태 ;손명희 pp.91-99

파킨슨병과 본태성 진전의 감별진단에서 I-123 IPT(I-123-N-(3-iodopropen-2-yl)-2β-carbomethoxy-3β-(4-cholorophenyl) tropane) 뇌 단일광전자방출 전산화단층촬영의 역할 배문선 ;최태현 ;안성민 ;최재용 ;류원기 ;이재훈 ;유영훈 pp.100-106

주 우울증 환자의 국소 뇌혈류 변화 연구 이원형 ;정용안 ;서예영 ;유익동 ;나세정 ;정현석 ;김기준 pp.107-111

급성 심근경색 환자의 Tc-99m Tetrofosmin 심근 관류 지연영상에서 관찰되는 역재분포 현상의 임상적 의의 박순아 ;김대응 ;김창근 ;정진원 ;김남호 ;김경호 pp.112-119

대장암 치료 후 추적 검사로서 F-18 FDG PET/CT의 역할 :혈청 CEA, CA 19-9 및 Computed Tomography와의 진단 성능 비교 강성민 ;송봉일 ;이홍제 ;서지형 ;이상우 ;유정수 ;안병철 ;이재태 ;최규석 ; pp.120-128

분화 갑상선암의 추적 관찰에서 진단적 I-123 전신스캔의 최적 영상 시점 :동일 환자에서 6시간과 24시간 영상의 비교 이홍제 ;이상우 ;송봉일 ;강성민 ;서지형 ;유정수 ;안병철 ;이재태 pp.129-136

병원간 전송용 PET/CT 영상 CD자료의 현황 및 문제점 현승협 ;최준영 ;이수진 ;조영석 ;이지영 ;천미주 ;조숙경 ;이경한 ;김병태 pp.137-142

편측성 측두하악관절장애 환자에서 골스캔을 이용한 교합안정장치 치료효과 예측 이상미 ;이원우 ;윤필영 ;김영균 ;김상은 pp.143-149

황색육아종성 신우신염 환자의 ^18^F-FDG PET/CT 소견 1예 최봉회 ;홍선표 ;윤준기 ;배기수 ;홍 정 ;임현이 pp.150-153

Incidental visualization of thyroid gland on bone scan caused by graves' hyperthyroidism Myung-Hee Sohn ;Hwan-Jeong Jeong ;Dong Wook Kim ;Seok Tae Lim pp.154-155

^18^F-FDG-avid adenocarcinoma of the rectum presenting as a subtle filling defect on maximum intensity projection image :report of a case Yong-Whee Bahk ;Kwang Chan Lee pp.156-158

참고문헌 (33건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F. Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci 1973;20:415-55. 미소장
2 Hornykiewicz O, Kish SJ. Biochemical physiology of Parkinson's disease. Arch Neuro 1987;45:19-23. 미소장
3 Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease 네이버 미소장
4 PET demonstrates different behaviour of striatal dopamine D-1 and D-2 receptors in early Parkinson's disease. 네이버 미소장
5 Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with parkinsonism 네이버 미소장
6 Tatsch K, Schwarz J, Mozley PD, Linke R, Pogarell O, Oertel WH, et al. Relationship between clinical features of Parkinson's disease and presynaptic dopamine transporter binding assessed with [123I]IPT and single-photon emission tomography. Eur J Nucl Med 1997;24:415-21. 미소장
7 Subdivisional involvement of nigrostriatal loop in idiopathic Parkinson's disease and striatonigral degeneration. 네이버 미소장
8 Hirai M, Kitamura N, Hashimoto T, Nakai T, Mita T, Shirakawa O, et al. [3H]GBR-12935 binding sites in human striatal membranes: binding characteristics and changes in parkinsonians and schizophrenics. Jpn J Pharmacol 1988;47:237-43. 미소장
9 Janowsky A, Vocci F, Berger P, Angel I, Zelnik N, Kleinman JE, et al. [3H]GBR-12935 binding to the dopamine transporter is decreased in the caudate nucleus in Parkinson's disease. J Neurochem 1987;49:617-21. 미소장
10 Maloteaux JM, Vanisberg MA, Laterre C, Javoy-Agid F, Agid Y, Laduron PM. [3H]GBR 12935 binding to dopamine uptake sites: subcellular localization and reduction in Parkinson's disease and progressive supranuclear palsy. Eur J Pharmacol 1988;156:331-40. 미소장
11 Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson's disease 네이버 미소장
12 The dopamine transporter: immunochemical characterization and localization in brain. 네이버 미소장
13 Extracellular dopamine in rat striatum following uptake inhibition by cocaine, nomifensine and benztropine 네이버 미소장
14 Mapping cocaine binding sites in human and baboon brain in vivo. 네이버 미소장
15 Cocaine: an in vivo microdialysis evaluation of its acute action on dopamine transmission in rat striatum. 네이버 미소장
16 Evaluation of early-stage Parkinson's disease with 99mTc-TRODAT-1 imaging. 네이버 미소장
17 Kim HJ, Lim JH, Yang SO, Ryu JS, Choi YY, Lee MJ et al. I-123 IPT SPECT Dopamine Reuptake Site Imaging : Differences in Normal Controls and Parkinson`s Patients by Semiquantitative analysis. Korean J Nuc Med 1996;30:35-46. 미소장
18 Imaging and quantitation of dopamine transporters with iodine-123-IPT in normal and Parkinson's disease subjects. 네이버 미소장
19 Im JH, Chung SJ, Kim JS, Lee MC. Differential patterns of dopamine transporter loss in the basal ganglia of progressive supranuclear palsy and Parkinson's disease: Analysis with [123I]IPT single photon emission computed tomography. J Neurol Sciences 2008;244:103-9. 미소장
20 Direct comparison of FP-CIT SPECT and F-DOPA PET in patients with Parkinson’s disease and healthy controls 네이버 미소장
21 Parkinson's disease dyskinesias. 네이버 미소장
22 Comparison of magnetic resonance and roentgen ray computed tomography in dementia. 네이버 미소장
23 Kohira I. The use of magnetic resonance imaging (MRI) and single photon emission computing tomography (SPECT) for the differential diagnosis of Parkinson's disease and other neurodegenerative disorders presenting as parkinsonism. Nippon Rinsho 1997;55:39-42. 미소장
24 Okada J, Peppard R, Calne DB. Comparison study of positron emission tomography, X-ray CT and MRI in parkinsonism with dementia. Nippon Igaku Hoshasen Gakkai Zasshi 1989;49:643-56. 미소장
25 Cognition and 99Tcm-HMPAO SPECT in Parkinson's disease. 네이버 미소장
26 Comparison Studies of SPECT Dopamine Transporter Imaging and Noninvasive Quantification using < Tc-99m > TRODAT-1 and IPT 소장
27 Imaging of dopamine transporters with technetium-99m TRODAT-1 and single photon emission computed tomography. 네이버 미소장
28 Technepine: A high‐affinity 99mtechnetium probe to label the dopamine transporter in brain by SPECT imaging 네이버 미소장
29 Binding of [99mTc]TRODAT-1 to dopamine transporters in patients with Parkinson's disease and in healthy volunteers. 네이버 미소장
30 Iodine-123-IPT SPECT imaging of CNS dopamine transporters: nonlinear effects of normal aging on striatal uptake values. 네이버 미소장
31 Essential tremor and its variants. 네이버 미소장
32 Striatal D2 receptor status in patients with Parkinson's disease, striatonigral degeneration, and progressive supranuclear palsy, measured with 11C-raclopride and positron emission tomography. 네이버 미소장
33 123I-IPT brain SPECT study in essential tremor and Parkinson's disease. 네이버 미소장

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