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Contents
EC-18, a synthetic monoacetyldiacylglyceride, inhibits hematogenous metastasis of KIGB-5 biliary cancer cell in hamster model / Myung-Hwan Kim ; Heung Moon Chang ; Tae Won Kim ; Sung Koo Lee ; Jung-Sun Park ; Young-Hoon Kim ; Tae Yoon Lee ; Se Jin Jang ; Chul-Won Suh ; Tae-Suk Lee ; Sang-Hee B Kim ; Sung-Gyu Lee 1
[요약] 1
Introduction 1
Materials and methods 2
Animals and cell lines 2
EC-18 2
T cell proliferation assay 2
Elispot assay of T cells 2
Measurement of cytokine secretion 2
Measurement of [Ca²+(이미지참조)] influx by flowcytometry 2
Cytotoxic T Lymphocytes (CTL) Assay 2
RT-PCR analysis of TLR-4 3
Real-time quantitative PCR analysis of TLR-4 3
Western blot analysis of TLR-4 3
In vivo experimental protocol 3
Statistical analysis 3
Results 3
T cell proliferation assay 3
IL-2 secretion by EC-18 treated T cells 3
Secretion of cytokines by EC-18 treated T cells 4
Measurement of [Ca²+(이미지참조)] influx of EC-18 4
Cytolytic activity of T cells from CE-18 treated hamsters 4
TLR-4 mRNA expressions of LPS stimulated biliary cancer cells with and without EC-18 4
TLR-4 protein expressions of LPS stimulated biliary cancer cells with and without EC-18 4
Pathology of metastatic biliary cancer in the lungs 5
Discussion 6
ACKNOWLEDGMENT 7
REFERENCES 7
초록보기
EC-18 (monoacetyldiacylglyceride) stimulates T cell production of IL-2, IL-4, IL-12,
IFN-γ, and GM-CSF in vitro. To study the effects of these cytokines stimulated by
EC-18 on cancer cells, we applied hamster biliary cancer model, a difficult cancer
to treat. Cancer (KIGB-5) cells were given intravenously to produce hematogenous
metastatic lung lesions which were treated with EC-18 at 10, 25, and 50 mg/kg/day
respectively. The fourth group was untreated control. At 4th, 8th, and 12th week the
lungs were examined. EC-18 treated groups showed only a few microscopic lung
lesions and no evidence of metastatic lesion with highest dose whereas widespread
gross lung lesions were observed in untreated control. To investigate whether the
anti-tumor effect of EC-18 is associated with suppression of tumor cell Toll-like receptor
4 (TLR-4) expression in addition to stimulation of the immune cells, KIGB-5 cells
were exposed to LPS with or without EC-18. TLR-4 mRNA and protein expression,
measured by reverse transcriptase PCR (RT-PCR), real-time quantitative PCR and
western blot analysis, showed suppression of TLR-4 expression in KIGB-5 cells
treated with EC-18 compared with control. In conclusion, EC-18 has a significant
anti-tumor effect in this experimental model of biliary cancer suggesting potential
for clinical application to this difficult cancer.권호기사
참고문헌 (20건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Cholangiocarcinoma  |
미소장 |
| 2 | A review and update on cholangiocarcinoma. |
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| 3 | Treatment of 283 Consecutive Patients With Metastatic Melanoma or Renal Cell Cancer Using High-Dose Bolus Interleukin 2 |
미소장 |
| 4 | Purification and Structural Determination of Hematopoietic Stem Cell-Stimulating Monoacetyldiglycerides from Cervus nippon (Deer Antler) |
미소장 |
| 5 | Stimulatory Effects of Monoacetyldiglycerides on Hematopoiesis(Miscellaneous) |
미소장 |
| 6 | Kim MH, Lee SS, Lee SK, Lee SG, Suh CW, Gong GY, Park JS, Kim YH, Kim SH. Interleukin-2 gene-encoded stromal cells inhibit the growth of metastatic cholangiocarcinomas. World J Gastroenterol 2006; 12: 1889-94. | 미소장 |
| 7 | Toll-like receptors on tumor cells facilitate evasion of immune surveillance. |
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| 8 | Korean patent application 10-2005-0065792 (2005. 7. 20). | 미소장 |
| 9 | Attenuation of retinal vascular development and neovascularization in PECAM-1-deficient mice. |
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| 10 | Systemic treatment with interleukin-4 induces regression of pulmonary metastases in a murine renal cell carcinoma model |
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| 11 | Peace DJ, Kern DE, Schultz KR, Greenberg PD, Cheever MA. IL-4-induced lymphokine-activated killer cells. Lytic activity is mediated by phenotypically distinct natural killer-like and T cell-like large granular lymphocytes. J Immunol 1988; 140: 3679-85. | 미소장 |
| 12 | Susceptibility of chemoresistant murine and human tumor cells to lysis by interleukin 2-activated lymphocytes. |
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| 13 | IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. |
미소장 |
| 14 | Human CD4+ effector T cells mediate indirect interleukin-12- and interferon-gamma-dependent suppression of autologous HLA-negative lung tumor xenografts in severe combined immunodeficient mice. |
미소장 |
| 15 | Metabolism of a long-chain diacylglycerol by permeabilized A10 smooth muscle cells. |
미소장 |
| 16 | Modulation of [Ca2+]i in freshly isolated mouse lymphocytes with in vivo priming. |
미소장 |
| 17 | Ca2+ signals and T lymphocytes; "New mechanisms and functions in Ca2+ signalling". |
미소장 |
| 18 | Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells. |
미소장 |
| 19 | Structure and functional properties of diacylglycerols in membranes. |
미소장 |
| 20 | Toll-like receptor signaling in anti-cancer immunity |
미소장 |
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