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Purpose: This study was conducted to examine the clinical factors which affected the amount and the duration of infusion of intravenous (IV) heparin on ischemic stroke. Method: A cross-sectional descriptive study was designed to examine the factors. A total of 101 patients with ischemic stroke from a University hospital in G-city, Korea from January to December, 2006 were participated in this study. Data were analyzed by t-and ANOVA test, correlation coefficient, and stepwise multiple linear regression analysis. Result: This study showed that the patients who have been temporarily stopped to infuse iv heparin for more than one hour, had cardioembolic stroke, and had the lower count of initial red blood cell (RBC) had significantly lower amount of iv heparin infusion per body surface. In addition, this study founded that the patients with lower count of initial RBC and the lower level of initial blood sugar were significantly less likely to have the lower length of iv heparin infusion. Conclusion: Continuous monitoring and controlling the count of RBC and the level of blood sugar are needed to increase the efficacy of iv heparin therapy on ischemic stroke. Further empirical studies should be conducted to support the results of this study.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
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참고문헌 (27건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Guidelines for the early management of patients with ischemic stroke: A scientific statement from the Stroke Council of the American Stroke Association. 네이버 미소장
2 Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. 네이버 미소장
3 Use of intravenous heparin by North American neurologists: do the data matter? 네이버 미소장
4 Impact of Admission Hyperglycemia on Stroke Outcome After Thrombolysis 네이버 미소장
5 Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial. 네이버 미소장
6 ATVB in focus: Diabetic vascular disease: pathophysiological mechanisms in the diabetic milieu and therapeutic implications. 네이버 미소장
7 A standard heparin nomogram for the management of heparin therapy. 네이버 미소장
8 Platelet activation in type 2 diabetes mellitus 네이버 미소장
9 Pharmacodynamics and kinetics of loss of tolerance and physical dependence on morphine induced by pellet implantation in the rat. 네이버 미소장
10 Role of Fibrinogen Levels and Factor XIII V34L Polymorphism in Thrombolytic Therapy in Stroke Patients 네이버 미소장
11 Hyperglycemia accelerates arterial thrombus formation and attenuates the antithrombotic response to endotoxin in mice 네이버 미소장
12 Hirsh, J., Dalen, J. E., Deykin, D., & Poller, L. (1992). Heparin: Mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety. Chest, 102(4 Suppl), 337S-351S. 미소장
13 Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes. 네이버 미소장
14 Frequency and risk factors for spontaneous hemorrhagic transformation of cerebral infarction 네이버 미소장
15 Marin, F., Roldan, V., Gonzalez-Conejero, R., & Corral, J. (2005). Pharmacogenetics in cardiovascular antithrombotic therapy. Curr Med Chem Cardiovasc Hematol Agents, 3, 357-364. 미소장
16 Efficacy and safety of anticoagulant treatment in acute cardioembolic stroke: a meta-analysis of randomized controlled trials. 네이버 미소장
17 Effectiveness of heparin treatment for progressing ischaemic stroke: before and after study 네이버 미소장
18 Anemia as a risk factor of hemorrhagic tendency during surgery. 네이버 미소장
19 Determinants of IV heparin treatment in patients with ischemic stroke. 네이버 미소장
20 Song, H. J., & Jang, S. H. (2001). Use of heparin nomogram in acute ischemic stroke patients. Ann Bull Bum-Suk Acad Sch Found, 5, 181- 185. 미소장
21 Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans. 네이버 미소장
22 Current Usage Pattern of Intravenous Heparin for Acute Ischemic Stroke by Neurologists in Korea 네이버 미소장
23 Pharmacogenetics of antithrombotic drugs. 네이버 미소장
24 Validation of a weight-based nomogram for the use of intravenous heparin in transient ischemic attack or stroke. 네이버 미소장
25 Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand. 네이버 미소장
26 Erythrocyte Promotion of Platelet Reactivity Decreases the Effectiveness of Aspirin as an Antithrombotic Therapeutic Modality 네이버 미소장
27 The Usage of Intravenous Heparin in Acute Ischemic Stroke in 10 Teaching Hospitals 소장