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Background/Aims: Darbepoetin alfa (DPO) exhibits comparable renoprotective effects to erythropoietin (EPO) in several animal models of acute renal injury. We examined whether DPO also attenuated renal injury in a rat model of cisplatin nephrotoxicity.

Methods: Male Spague-Dawley rats were divided into four groups: untreated, DPO-treated, cisplatin-injected, and DPO-treated cisplatin-injected. DPO pretreatment was conducted 24 hours after and just before cisplatin

administration. Ninety-six hours after cisplatin administration, animals in all experimental groups were sacrificed. We examined serology; real-time reverse transcription polymerase chain reaction (RT-PCR) for TNF-α, Bcl-2, and MCP-1 gene expression; and Western blots for caspase-3. We also conducted terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and light microscopy.

Results: Pretreatment with DPO significantly reduced the levels of blood urea nitrogen and serum creatinine, the magnitude of renal tubular epithelial damage, and renal gene expression of TNF-α, Fas, and MCP-1 in kidneys

injured by cisplatin. Pretreatment with DPO significantly increased Bcl-2 mRNA levels in kidneys injured by cisplatin, and significantly reduced activated caspase-3 and TUNEL-positive cells.

Conclusions: DPO exhibits a renoprotective effect in experimental cisplatin-induced renal injury, the mechanism of which may involve DPO antiinflammatory and antiapoptotic effects.

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참고문헌 (29건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin toxicity. 네이버 미소장
2 Cisplatin nephrotoxicity: a review. 네이버 미소장
3 Parthenolide reduces cisplatin-induced renal damage 네이버 미소장
4 Simvastatin attenuates cisplatin-induced kidney and liver damage in rats 네이버 미소장
5 A comparison of the effects of tetraplatin and cisplatin on renal function and gentamicin pharmacology in rats 네이버 미소장
6 Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats 네이버 미소장
7 Bernaudin M, Marti HH, Roussel S, et al. A potential role for erythropoietin in focal permanent cerebral ischemia in mice. J Cereb Blood Flow Metab 1999;19:643-651. 미소장
8 Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia. 네이버 미소장
9 An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection 네이버 미소장
10 Erythropoietin protects against ischaemic acute renal injury 네이버 미소장
11 Erythropoietin enhances recovery after cisplatin‐induced acute renal failure in the rat 네이버 미소장
12 Attenuation of Interstitial Inflammation and Fibrosis by Recombinant Human Erythropoietin in Chronic Cyclosporine Nephropathy 네이버 미소장
13 NOVEL ERYTHROPOIESIS STIMULATING PROTEIN (NESP) MAINTAINS HAEMOGLOBIN IN ESRD PATIENTS WHEN ADMINISTERED ONCE WEEKLY OR ONCE EVERY OTHER WEEK 네이버 미소장
14 Johnson DW, Pat B, Vesey DA, Guan Z, Endre Z, Gobe GC. Delayed administration of darbepoetin or erythropoietin protects against ischemic acute renal injury and failure. Kidney Int 2006;69:1806- 1813. 미소장
15 Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death. 네이버 미소장
16 Role of early plasma membrane events in chemotherapy-induced cell death 네이버 미소장
17 Cisplatin-induced nephrotoxicity is mediated by tumor necrosis factor-alpha produced by renal parenchymal cells. 네이버 미소장
18 Premkumar K, Abraham SK, Santhiya ST, Ramesh A. Inhibitory effects of aqueous crude extract of Saffron (Crocus sativus L.) on chemical-induced genotoxicity in mice. Asia Pac J Clin Nutr 2003;12:474-476. 미소장
19 TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. 네이버 미소장
20 Darbepoetin alfa. Amgen. 네이버 미소장
21 Smith RE Jr, Jaiyesimi IA, Meza LA, et al. Novel erythropoiesis stimulating protein (NESP) for the treatment of anaemia of chronic disease associated with cancer. Br J Cancer 2001;84(Suppl 1):24-30. 미소장
22 Preconditioning with erythropoietin protects against subsequent ischemia-reperfusion injury in rat kidney. 네이버 미소장
23 Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. 네이버 미소장
24 Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart. 네이버 미소장
25 Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. 네이버 미소장
26 Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis 네이버 미소장
27 Cytoprotection by darbepoetin/epoetin alfa in pig tubular and mouse mesangial cells. 네이버 미소장
28 Erythropoietin enhances recovery from cisplatin-induced acute renal failure. 네이버 미소장
29 Thrombosis in End-Stage Renal Disease 네이버 미소장

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