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Objective : Cerebral vasospasm leading to cerebral ischemic infarction is a major cause of morbidity and mortality in the patients who suffer
with aneurysmal subarachnoid hemorrhage. Despite adequate treatment, some patients deteriorate and they develop symptomatic vasospasm.
The objective of the present study was to investigate the efficacy and clinical outcome of intraarterial nimodipine infusion on symptomatic
vasospasm that is refractory to hemodynamic therapy.
Methods : We retrospectively reviewed the procedure reports, the clinical charts and the transcranial doppler, computed tomography and digital
subtraction angiography results for the patients who underwent endovascular treatment for symptomatic cerebral vasospasm due to aneurysmal
SAH. During the 36 months between Jan. 2005 and Dec. 2007, 19 patients were identified who had undergone a total of 53 procedures. We
assessed the difference in the arterial vessel diameter, the blood flow velocity and the clinical outcome before and after these procedures.
Results : Vascular dilatation was observed in 42 of 53 procedures. The velocities of the affected vessels before and after procedures were
available in 33 of 53 procedures. Twenty-nine procedures exhibited a mean decrease of 84.1 cm/s. We observed clinical improvement and an
improved level of consciousness with an improved GCS score after 23 procedures.
Conclusion : Based on our results, the use of intraarterial nimodipine is effective and safe in selected cases of vasospasm following aneurysmal
SAH. Prospective, randomized studies are needed to confirm these results.*표시는 필수 입력사항입니다.
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도서위치안내: 정기간행물실(524호) / 서가번호: 국내17
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