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Background: Obstructive sleep apnea (OSA) is associated with several cardiovascular diseases. However, the mechanisms

are not completely understood. The measure of common carotid artery intima-media thickness (IMT) has been extensively

used as an early marker of atherosclerosis. The aim of this study was to test the hypothesis that early signs of atherosclerosis

are present in patients with OSA and correlate with OSA severity Methods: Eleven male patients with OSA were studied

by using full standard overnight polysomnography and high-definition echo-tracking device to measure intima-media thickness

and carotid artery diameter. Eight healthy volunteers matched for age and sex were studied by portable respiratory monitoring

device. All participants were free of hypertension, diabetes, and were not on any medications. Patients with OSA

were naive to treatment. Results: All patients and normal controls were male. There was no significant difference of age

between patients and controls (48.4?.85 and 48.0?.77). Significant differences existed between control subjects and patients

with mild to moderate and severe OSA (apnea-hypopnea index, 1.51?.15 and 38.51?9.13 respectively) in intima-media

thickness (0.59?.064 and 0.93?.16; P=0.0023), and carotid diameter (5.79?.44 and 6.47?.51; P=0.0227). Multivariate

analyses showed that the apnea-hypopnea index correlated independently with intima-media thickness and carotid diameter

(r=0.79, P=0.0008, and r=0.47, P=0.0482). Conclusions: Middle-aged patients with OSA who are free of overt cardiovascular

diseases have early signs of atherosclerosis,

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기사명 저자명 페이지 원문 목차
추간판성통증 동물모델의 개발 : 초기 연구 김병조 ; 이 민 ; 임은정 ; 유성욱 ; 홍성하 ; 홍석주 ; 나흥식 pp.41-47

급성 벨마비 환자의 자가보고형 불안 및 우울평가 유지훈 ; 한우호 ; 이동국 pp.48-53

폐쇄성수면무호흡과 목동맥동맥경화증의 상관관계 조재욱 ; 김용완 ; 이현순 ; 전두수 ; 김윤성 ; 정대수 pp.54-58

미요시근육병 환자에서 밝혀진 Dysferlin 유전자 돌연변이 지명구 ; 김남희 ; 김대성 ; 최영철 pp.59-63

스테로이드 치료에 의해 빠르게 호전된 특발성 급성 종단성 척수염 1예 강성원 ; 정진성 ; 강현구 ; 정주리 ; 김수성 ; 한선정 ; 이성익 ; 양현덕 ; 손일홍 pp.64-66

근전도상 근긴장증이 관찰되는 콜치신에 의한 근병증 1예 양지원 ; 김나래 ; 박기형 pp.67-70

Transient biclonal gammopathy associated with tsutsugamushi meningitis Hyun-Young Park ; Soo-Seong Kim ; Hak-Seung Lee ; Hyuk Chang ; Kwang-Ho Cho ; Yo-Sik Kim pp.71-73

Adult sandhoff disease presenting as motor neuron disease phenotype Suk-Won Ahn ; Su-Hyun Kim ; Suyun Kim ; Sung-Min Kim ; Kwang-Woo Lee ; Jung-Joon Sung pp.74-77

총경정맥영양공급을 받던 환자에게 발생한 베르니케 뇌병증 이재영 ; 김지영 ; 강지훈 ; 최재철 ; 이정석 ; 강사윤 pp.78-80

소뇌다리뇌각수막종에 의해 발병한 반얼굴연축의 신경생리학적 검사 소견 김대성 ; 이상원 pp.81-82

참고문헌 (23건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Yun CH. A diagnosis and treatment of obstructive sleep apnea syndrome. J Kor Sleep Research Soc 2004;1:34-40. 미소장
2 Epidemiology of obstructive sleep apnea syndrome. 네이버 미소장
3 The occurrence of sleep-disordered breathing among middle-aged adults. 네이버 미소장
4 Prevalence of sleep-disordered breathing in middle-aged Korean men and women. 네이버 미소장
5 Obstructive sleep apnoea 네이버 미소장
6 Association of Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large Community-Based Study 네이버 미소장
7 Cognitive Dysfunctions in Patients With Severe Obstructive Sleep Apnea Syndrome: Neuropsychological Test and Event-Related Potential Study 소장
8 Obstructive sleep apnea as a risk factor for stroke and death. 네이버 미소장
9 Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study 네이버 미소장
10 Obstructive sleep apnea and atherosclerosis: a new paradigm. 네이버 미소장
11 Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. 네이버 미소장
12 Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. 네이버 미소장
13 A new method for measuring daytime sleepiness: the Epworth sleepiness scale. 네이버 미소장
14 Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. 네이버 미소장
15 Impact of Obstructive Sleep Apnea on Carotid Intima-Media Thickness 소장
16 Carotid artery wall thickness in patients with obstructive sleep apnea syndrome. 네이버 미소장
17 Obstructive sleep apnea and carotid-artery intima-media thickness. 네이버 미소장
18 Sleep apnea and cardiovascular disease: an American Heart Association/american College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). 네이버 미소장
19 Increased carotid intima-media thickness and serum inflammatory markers in obstructive sleep apnea. 네이버 미소장
20 Steinke W, Els T, Hennerici M. Compensatory carotid artery dilatation in early atherosclerosis. Circulation 1994;89:2578- 2581. 미소장
21 Evaluation of a portable device for diagnosing the sleep apnoea/hypopnoea syndrome. 네이버 미소장
22 Evaluation of a Novel Ambulatory Device for Screening of Sleep Apnea 네이버 미소장
23 Diagnosis of Obstructive Sleep Apnea Syndrome and Its Outcomes With Home Portable Monitoring 네이버 미소장

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