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초록보기
In our previous study, a new herbal preparation (HemoHIM) was developed as a functional food for the radioprotection and immunomodulatory agents. In order elucidate the mechanism involved, we examined the effect of HemoHIM on the compound 48/80-induced histamine release, and on the phorbol 12-myristate 13-acetate (PMA)/calcium ionophore (A23187)-induced inflammatory cytokine secretion in HMC-1. The cell culture supernatants were harvested, and the cytokines (IL-4, IL-6, IL-8, TNF-α, GM-CSF) in the supernatants were measured by enzyme-linked immunosorbent assay. The total RNA of the cells was extracted, and the cytokines or c-kit/tryptase/FcεRI's messenger RNA expressions were examined using reverse transcriptase polymerase chain reaction. Under low concentrations, HemoHIM inhibited histamine release in HMC-1 stimulated compound 48/80. Futhermore HemoHIM inhibited PMA/A23187-induced inflammatory cytokines' secreation or mRNA expression in a dose-dependent manner. But IL-8 secretion was not inhibited by low concentrayion of HemoHIM, respectively. The mRNA expression of c-kit and FcεRI were also inhibited in a dose-dependent manner. Tryptase mRNA expression was only inhibited by low concentration of HemoHIM. These results indicated that HemoHIM might be an useful agent for protection against allergy as well as immune modulation, especially since it is a relatively nontoxic natural product.
권호기사
참고문헌 (35건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis.  |
미소장 |
| 2 | Anti-inflammatory actions of steroids: molecular mechanisms |
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| 3 | Butler, D. M., R. N. Maini, M. Feldmann, and F. M. Brennan. 1995. Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist. Eur. Cytokine Netw. 6, 225-230. | 미소장 |
| 4 | Caufield, J. P., R. A. Lois, A. Hein, and K. F. Austen. 1980. Secretion in dissociated human plumanary mast cells. Evidence for solubilization of granule contents before discharge. J. Cell Biol. 85, 29-37. | 미소장 |
| 5 | Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. |
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| 6 | Harada, A., N. Mukaida, and K. Matsushima. 1996. Interleukin 8 as a novel target for intervention theraphy in acute inflammatory disease. Mol. Med. Today 2, 482-489. | 미소장 |
| 7 | Jo, S. K., Y. B. Yu, H. Oh, S. R. Kim, and S. H. Kim. 2000. The effects of Shi-Quan-Dai-Bu-Tang and its ingredients on the survival of jejunal crypt cells and hematopoietic cells in irradiated mice. J. Korean Soc. Food Sci. Nutr. 29, 93-98. | 미소장 |
| 8 | Jo, S. K., H. R. Park, U. H. Jung, H. Oh, S. H. Kim, and S. E. Lee. 2005. Protective effect of a herbal preparation (HemoHIM) on the self-renewal tissues and immune system against γ-Irradiation. J. Korean Soc. Food Sci. Nutr. 34, 805-813. | 미소장 |
| 9 | Kang, K. J., B. D. Jun, O. H. Chai, and M. S. Lee. 1993. Inhibitory effects of Mori cortex on compound 48/80-induced histamine release and calcium uptake of rat peritoneal mast cells. Korean J. Immunol. 15, 91-99. | 미소장 |
| 10 | Kang, O. K., H. S. Chae, J. H. Choi, H. J. Choi, P. S. Park, S. H. Cho, G. H. Lee, H. Y. So, Y. K. Choo, O. H. Kweon, and D. Y. Kwon. 2006. Effect of the Schisandra fructus water extract on cytokine release from human mast cell line. J. Med. Food 9, 480-486. | 미소장 |
| 11 | Kay, A. B. 2006. The role of T lymphocyte in asthma. Chem. Immunol. Allergy 91, 59-75. | 미소장 |
| 12 | The Radioprotective Effects of Bu-Zhong-Yi-Qi-Tang: A Prescription of Traditional Chinese Medicine |
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| 13 | Kim, S. H., S. E. Lee, H. Oh, J. A. Yang, C. Y. Chung, J. S. Jang, Y. B. Yu, and S. K. Jo. 1999. The radioprotective effect of Kuei-Pi- Tang as a prescription of traditional Chinese medicine in mice. J. Korean Soc. Food Sci. Nutr. 28, 698-704. | 미소장 |
| 14 | Kim, S. H., M. R. An, S. Y. Nah, J. H. Lee, J. H. Kim, S. K. Jo, S. J. Jang, and D. H. Shin. 2001. The effects of herbs on the radiation-induced apoptosis in intestinal crypt cells. J. Korean Assoc. Radiat. Prot. 26, 27-33. | 미소장 |
| 15 | Kim, S. H., H. Oh, S. R. Kim, S. K. Jo, M. W. Byun, K. S. Kim, J. H. Lee, and D. H. Shin. 2001. The radioprotective effects of radices herbs. Korea J. Vet. Res. 41, 105-111. | 미소장 |
| 16 | Kim, S. H., H. Oh, E. S. Lee, S. K. Jo, and M. W. Byun. 1998. Effect of Si-Wu-Tang and Si-Jun-Zi-Tang on the survival of jejunal crypt cells and hematopoietic cells in irradiated mice. Korean J. Food Sci. Technol. 30, 888-894. | 미소장 |
| 17 | Inhibitory Effect of Isodon japonicus Hara on Mast Cell-Mediated Immediate-Type Allergic Reactions | 소장 |
| 18 | Lee, S. W., Y. M. Ye, J. H. Choi, S. H. Kim, C. H. Suh, and D. H. Nahm. et al. 2004. Measurement of serum tryptase in the diagnosis of systemetic allergic reaction. Korean J. Med. 67, 185-189. | 미소장 |
| 19 | Radioprotective Effects of Two Traditional Chinese Medicine Prescriptions: Si-Wu-Tang and Si-Jun-Zi-Tang |
미소장 |
| 20 | Lee, M. S., Y. G. Ryu, O. K. Chai, K. J. Kang and J. Y. Lee. 1999. Inhibitory effect of polysaccharide fraction from Cortex mori on compound 48/80-induced mast cell activation. Korean J. Immunol. 21, 35-45. | 미소장 |
| 21 | Li, G. Z., O. H. Chai, and C. H. Song. 2004. Inhibitory effect of Rubus coreanus on compound 48/80- or anti-DNP IgE-induced mast cell activation. Immune. Network 4, 100-107. | 미소장 |
| 22 | Stem cell factor and its soluble receptor (c-kit) in serum of asthmatic patients- correlation with disease severity |
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| 23 | NF-kappa B is activated during acute inflammation in vivo in association with elevated endothelial cell adhesion molecule gene expression and leukocyte recruitment. |
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| 24 | Oh, H., H. R. Park, I. Y. Jeong, S. H. Kim, and S. K. Jo. 2002. Protective effects of Paeonia japonica against radiation-induced damage. J. Korean Assoc. Radiat. Prot. 27, 181-188. | 미소장 |
| 25 | Clinical aspects of food allergy |
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| 26 | Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice |
미소장 |
| 27 | Park, H. R., S. H. Kim, S. T. Yee, M. W. Byun, and S. K. Jo. 2005. Effects of a herb mixture (HIM-I) on the protection of the hematopoietic-immune system and self-renewal tissues against radiation damage. J. Korean Soc. Food Sci. Nutr. 34, 605-612. | 미소장 |
| 28 | Pastore, S., E. Fanales-Belasio, C. Albanesi, LM. Chinni, A. Giannetti, and G. Girolomoni. 1997. Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis. Implications for sustained dendritic cell activation in the skin. J. Clin. Invest 99, 3009-3017. | 미소장 |
| 29 | Mast cell tryptase: a review of its physiology and clinical significance |
미소장 |
| 30 | Immunology in the new millennium: building on tradition |
미소장 |
| 31 | Effect of Quercetin, Caffeic Acid and Caffeic Acid Phenylethyl Ester, Solubilized in Non-ionic Surfactants, on Histamine Release in vivo and in vitro |
미소장 |
| 32 | Seo, U. K., J. I. Lee, J. H. Park, and Y. K. Park. 2008. The ethylacetate extract of north kangwhal (Ostericum koreanum) attenuates the inflammatory responses in PMA/ A23187-stimulated mast cells. Kor. J. Herbology 23, 81-89. | 미소장 |
| 33 | Inhibitory effect of mast cell-dependent anaphylaxis byGleditsia sinensis | 소장 |
| 34 | Role of cytoskeletons on Ca2+ release from the intracellular Ca store of rat peritoneal mast cells. |
미소장 |
| 35 | Role of endoplasmic reticulum, an intracellular Ca2+ store, in histamine release from rat peritoneal mast cell |
미소장 |
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