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Purpose

This is an ad hoc analysis of two phase II studies which compared the efficacy and safety of two taxanes (paclitaxel and docetaxel) combined with 5-fluorouracil (5-FU) and leucovorin (LV) in advanced gastric cancer.

Materials and Methods

Patients with advanced gastric adenocarcinoma who were untreated or had only received first-line chemotherapy, were treated with either paclitaxel (PFL; 175 mg/m2) or docetaxel (DFL; 75 mg/m2) on day 1, followed by a bolus of LV (20 mg/m2 days 1∼3) and a 24-hour infusion of 5-FU (1,000 mg/m2 days 1∼3) every 3 weeks. The primary endpoint was overall response rate (ORR) and the secondary endpoint included survival and toxicity.

Results

Sixty-six patients received DFL (first-line [n=38]; and second-line [n=28]) and 60 patients received PFL (first-line [n=37]; and second-line [n=23]). The ORRs were not significantly different between the 2 groups (DFL, 26%; PFL, 38%). With a median follow-up of 9.5 months, the progression free survival was 5.2 months (95% confidence interval [CI], 4.2∼6.5 months) for DFL and 3.3 months (95% CI, 1.3∼5.5 months) for PFL (p=0.17). The overall survival was also comparable between the patients who received DFL and PFL (10.0 months [95% CI, 7.2 ∼12.5 months] and 13.9 months [95% CI, 10.9∼19.2 months], respectively; p=0.37). The most frequent grade 3∼4 adverse event was neutropenia (DFL, 71%; PFL, 62%). DFL and PFL had different non-hematologic toxicities; specifically, grade ≥3 mucositis (5%) and diarrhea (3%) were common in DFL, while nausea/vomiting (15%) and peripheral neuropathy (5%) were common in PFL.

Conclusion

Thus, the two taxanes had similar efficacy in the treatment of advanced gastric cancer, but different toxicity profiles. Prospective comparative studies are required to further clarify the role of taxanes in the treatment of advanced gastric cancer.

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기사명 저자명 페이지 원문 목차
Significance of cellular senescence in aging and cancer Angela Grimes ;Sathees B.C.Chandra pp.187-195

Docetaxel versus paclitaxel combined with 5-FU and leucovorin in advanced gastric cancer :combined analysis of two phase Ⅱ trials Hong Jae Chon ;Sun Young Rha ;Chong Kun Im ;Chan Kim ;Min Hee Hong ;Hye Ryun Kim ;Jung Ryun An ;Sung pp.196-204

Biopsy related prostate status does not affect on the clinicopathological outcome of robotic assisted laparoscopic radical prostatectomy Hoon Choi ;Young Hwii Ko ;Sung Gu Kang ;Seok Ho Kang ;Hong Seok Park ;Jun Cheon ;Vipul R. Patel pp.205-210

No association between promoter polymorphism of STK11 gene and lung cancer risk in the Korean population Jae Sook Sung ;Young Mi Whang ;Kyong Hwa Park ;Jeong-Seon Ryu ;Jong Gwon Choi ;Jae Hong Seo ;Sang Wo pp.211-217

No association of vascular endothelial growth factor-A (VEGF-A) and VEGF-C expression with survival in patients with gastric cancer Soo Jung Lee ;Jong Gwang Kim ;Sang Kyun Sohn ;Yee Soo Chae ;Joon Ho Moon ;Shi Nae Kim ;Han-Ik Bae ;H pp.218-223

Mutational analysis of TTK gene in gastric and colorectal cancers with microsatellite instability Chang Hyeok Ahn ;Yoo Ri Kim ;Sung Soo Kim ;Nam Jin Yoo ;Sug Hyung Lee pp.224-228

Mixed testicular germ cell tumor presenting as metastatic pure choriocarcinoma involving multiple lung metastases that was effectively treated with high-dose chemotherapy Sang-Cheol Lee ;Kyoung Ha Kim ;Sung Han Kim ;Nam Su Lee ;Hee Sook Park ;Jong-Ho Won pp.229-232

(A)Case of desmoplastic small round cell tumor diagnosed in a young female patient Ji-Won Kim ;Jin Hyun Park ;Hyeon Jin Cho ;Ji-Hyun Kwon ;Youngil Koh ;Su-Jung Kim ;Se Hyung Kim ;Se-H pp.233-236

Pseudoaneurysm due to squamous cell carcinoma of the lung :two cases of spontaneous resolution after chemotherapy So-Young Kim ;Hak-Ryul Kim ;Jung-Sub Song ;Ki-Eun Hwang ;Jeong-Hyun Shin ;Seoung-Nam Shin ;Dong Kim pp.237-240

(A)Case of spine origin chondroblastoma metastasis to lung Se Hoon Sohn ;Sung Aee Koh ;Dong Geun Kim ;Sung Woo Park ;Kyung Hee Lee ;Min Kyoung Kim ;Jun Hyuk Ch pp.241-244

참고문헌 (18건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 FAM Versus Etoposide, Adriamycin, and Cisplatin: A Random Assignment Trial in Advanced Gastric Cancer 소장
2 Docetaxel and continuous-infusion fluorouracil versus epirubicin, cisplatin, and fluorouracil for advanced gastric adenocarcinoma: a randomized phase II study. 네이버 미소장
3 Paclitaxel, 5‐fluorouracil, and cisplatin combination chemotherapy for the treatment of advanced gastric carcinoma 네이버 미소장
4 Phase II trial of the combination of paclitaxel and 5-fluorouracil in the treatment of advanced gastric cancer: a novel, safe, and effective regimen. 네이버 미소장
5 A phase II trial of paclitaxel and weekly 24 h infusion of 5-fluorouracil/folinic acid in patients with advanced gastric cancer. 네이버 미소장
6 In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer 네이버 미소장
7 A phase II study of infusional 5-fluorouracil and low-dose leucovorin with docetaxel for advanced gastric cancer. 네이버 미소장
8 A phase II study of paclitaxel combined with infusional 5-fluorouracil and low-dose leucovorin for advanced gastric cancer 네이버 미소장
9 Taxane-platinum combinations in advanced non-small cell lung cancer: a review. 네이버 미소장
10 Prospective randomised phase II study of docetaxel versus paclitaxel administered weekly in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy 네이버 미소장
11 Randomized phase III study of docetaxel compared with paclitaxel in metastatic breast cancer. 네이버 미소장
12 Phase III Randomized Trial of Docetaxel–Carboplatin Versus Paclitaxel–Carboplatin as First-line Chemotherapy for Ovarian Carcinoma 네이버 미소장
13 Imamura H, IIishi H, Tsuburaya A, Hatake K, Imamoto H, Esaki T, et al. Randomized phase III study of irinotecan plus S-1 (IRIS) versus S-1 alone as first-line treatment for advanced gastric cancer. ASCO Meeting Proc. 2007;25:S18. 미소장
14 S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial 네이버 미소장
15 Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. 네이버 미소장
16 Paclitaxel versus docetaxel for advanced gastric cancer: a randomized phase II trial in combination with infusional 5-fluorouracil 네이버 미소장
17 Phase I/II study of S-1 combined with weekly docetaxel in patients with metastatic gastric carcinoma. 네이버 미소장
18 Phase II study of weekly paclitaxel and 24-hour infusion of high-dose 5-fluorouracil and leucovorin in the treatment of recurrent or metastatic gastric cancer. 네이버 미소장

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