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Contents

Clinical characteristics and risk factors for nosocomial candidemia in medical intensive care units : experience in a single hospital in Korea for 6.6 years / Seon-Sook Han ; Jae-Joon Yim ; Chul-Gyu Yoo ; Young Whan Kim ; Sung Koo Han ; Young-Soo Shim ; Sang-Min Lee 1

[요약] 1

Introduction 1

Materials and methods 1

Study design and patients 1

Definitions 2

Matching procedure 2

Statistical analysis 2

Results 2

Analysis of patients with candidemia 2

Comparison of candidemia patients with matched control patients 3

Discussion 4

Acknowledgements 5

References 5

초록보기

The aim of this study was to determine candidemia incidence among patients in a

medical intensive-care unit (MICU) and the associated mortality rate and to identify

risk factors associated with candidemia. We retrospectively performed a 1:3 matched

case-control study of MICU patients with candidemia. Controls were matched for

sex, age, and Acute Physiology and Chronic Health Evaluation (APACHE) II score.

Candidemia incidence was 9.1 per 1,000 admissions. The most common pathogen

was Candida albicans. Crude mortality was 96% among candidemia patients and

52% among controls (P<0.001). Mortality differed significantly between the groups

according to Kaplan-Meier survival analysis (P=0.024). Multivariate analysis identified

the following independent risk factors for candidemia: central venous catheterization

(odds ratio [OR] = 3.2, 95% confidence interval [CI]=1.2-9.0), previous steroid

therapy (OR=4.7, 95% CI=1.8-12.1), blood transfusion during the same admission

period (OR=6.3, 95% CI=2.4-16.7), and hepatic failure upon MICU admission

(OR=6.9, 95% CI=1.7-28.4). In conclusion, we identify an additional independent risk

factor for candidemia, the presence of hepatic failure on MICU admission. Therefore,

increased awareness of risk factors, including hepatic failure, is necessary for the management

of candidemia.

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참고문헌 (30건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Epidemiology of Candida species infections in critically ill non-immunosuppressed patients 네이버 미소장
2 Bassetti M, Righi E, Costa A, Fasce R, Molinari MP, Rosso R, Pallavicini FB, Viscoli C. Epidemiological trends in nosocomial candidemia in intensive care. BMC Infect Dis 2007; 6: 21. 미소장
3 Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study 네이버 미소장
4 A prospective epidemiological survey of candidaemia in Sweden. 네이버 미소장
5 Puzniak L, Teutsch S, Powderly W, Polish L. Has the epidemiology of nosocomial candidemia changed? Infect Control Hosp Epidemiol 2004; 25: 628-33. 미소장
6 Excess Mortality, Hospital Stay, and Cost Due to Candidemia: A Case-Control Study Using Data From Population-Based Candidemia Surveillance 네이버 미소장
7 Alonso-Valle H, Acha O, Garcia-Palomo JD, Farinas-Alvarez C, Fernandez- Mazarrasa C, Farinas MC. Candidemia in a tertiary care hospital: epidemiology and factors influencing mortality. Eur J Clin Microbiol Infect Dis 2003; 22: 254-7. 미소장
8 An analysis of hospital-acquired bacteraemia in intensive care unit patients in a university hospital in Kuwait 네이버 미소장
9 Attributable Mortality of Nosocomial Candidemia, Revisited 네이버 미소장
10 Factors Associated with the Development of Candidemia and Candidemia-Related Death Among Liver Transplant Recipients 네이버 미소장
11 Trends in Mortality Due to Invasive Mycotic Diseases in the United States, 1980–1997 네이버 미소장
12 Candidemia in non-neutropenic critically ill patients: analysis of prognostic factors and assessment of systemic antifungal therapy 네이버 미소장
13 Epidemiology and the Internet 네이버 미소장
14 Managing the challenges of invasive fungal infections. 네이버 미소장
15 A Randomized and Blinded Multicenter Trial of High-Dose Fluconazole plus Placebo versus Fluconazole plus Amphotericin B as Therapy for Candidemia and Its Consequences in Nonneutropenic Subjects 네이버 미소장
16 APACHE II: a severity of disease classification system. 네이버 미소장
17 Effects of nosocomial candidemia on outcomes of critically ill patients 네이버 미소장
18 Risk Factors for the Development of Nosocomial Candidemia among Patients in Intensive Care Unit. 소장
19 Wey SB, Mori M, Pfaller MA, Woolson RF, Wenzel RP. Hospitalacquired candidemia. The attributable mortality and excess length stay. Arch Intern Med 1998; 148: 2642-5. 미소장
20 The changing epidemiology of invasive fungal infections: new threats. 네이버 미소장
21 Falagas ME, Apostolou KE, Pappas VD. Attributable mortality of candidemia: a systematic review of matched cohort and case control studies. Eur J Clin Microbiol Infect Dis 2006; 25: 419-25. 미소장
22 Fungal infection: a common, unrecognised complication of acute liver failure 네이버 미소장
23 Bacterial and fungal infection in acute liver failure. 네이버 미소장
24 Small intestine dysmotility and bacterial overgrowth in cirrhotic patients with spontaneous bacterial peritonitis. 네이버 미소장
25 Fungal colonisation and fluconazole therapy in acute liver disease. 네이버 미소장
26 Impaired Function of Macrophage Fcγ Receptors and Bacterial Infection in Alcoholic Cirrhosis 네이버 미소장
27 Macrophage function in cirrhosis and the risk of bacterial infection. 네이버 미소장
28 Acquired C3 deficiency in patients with alcoholic cirrhosis predisposes to infection and increased mortality. 네이버 미소장
29 Times to detection of bacteria and yeasts in BACTEC 9240 blood culture bottles. 네이버 미소장
30 Saito T, Senda K, Takakura S, Fujihara N, Kudo T, Iinuma Y, Tanimoto M, Ichiyama S. Detection of bacteria and fungi in BacT/Alert standard blood-culture bottles. J Infect Chemother 2003; 9: 227-32. 미소장

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