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한국학술지인용색인(NRF)
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Contents
Individualized tumor response testing for prediction of response to paclitaxel and cisplatin chemotherapy in patients with advanced gastric cancer / Jee Hyun Kim ; Keun-Wook Lee ; Yeul Hong Kim ; Kyung Hee Lee ; Do Youn Oh ; Joonhee Kim ; Sung Hyun Yang ; Seock-Ah Im ; Sung Ho Choi ; Yung-Jue Bang 1
[요약] 1
Introduction 1
Materials and methods 2
Study design 2
Patients 2
ATP-based chemotherapy response assay 2
Assessment of clinical and in vitro response 2
Statistical considerations 3
Results 3
Patient characteristics 3
Response and survival 4
In vitro chemosensitivity results 4
Discussion 5
References 6
초록보기
The purpose of our study was to determine the most accurate analytic method to
define in vitro chemosensitivity, using clinical response as reference standard in
prospective clinical trial, and to assess accuracy of adenosine triphosphate-based
chemotherapy response assay (ATP-CRA). Forty-eight patients with chemo-na?e,
histologically confirmed, locally advanced or metastatic gastric cancer were enrolled
for the study and were treated with combination chemotherapy of paclitaxel 175
mg/m2 and cisplatin 75 mg/m2 for maximum of six cycles after obtaining specimen
for ATP-CRA. We performed the receiver operator characteristic curve analysis
using patient responses by WHO criteria and ATP-CRA results to define the method
with the highest accuracy. Median progression free survival was 4.2 months (95%
confidence interval [CI]: 3.4-5.0) and median overall survival was 11.8 months (95%
CI: 9.7-13.8) for all enrolled patients. Chemosensitivity index method yielded highest
accuracy of 77.8% by ROC curve analysis, and the specificity, sensitivity, positive
and negative predictive values were 95.7%, 46.2%, 85.7%, and 75.9%. In vitro
chemosensitive group showed higher response rate (85.7% vs. 24.1%) (P=0.005)
compared to chemoresistant group. ATP-CRA could predict clinical response to
paclitaxel and cisplatin chemotherapy with high accuracy in advanced gastric cancer
patients. Our study supports the use of ATP-CRA in further validation studies.권호기사
참고문헌 (23건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | American Society of Clinical Oncology Technology Assessment: chemotherapy sensitivity and resistance assays.  |
미소장 |
| 2 | Prospective clinical trial of a human tumor cloning system. |
미소장 |
| 3 | Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. |
미소장 |
| 4 | Correlation of In Vitro Drug-Sensitivity Testing Results With Response to Chemotherapy and Survival in Extensive-Stage Small Cell Lung Cancer: A Prospective Clinical Trial |
미소장 |
| 5 | Chemotherapy sensitivity and resistance assays: a systematic review. |
미소장 |
| 6 | Chemosensitivity testing of human tumors using a microplate adenosine triphosphate luminescence assay: clinical correlation for cisplatin resistance of ovarian carcinoma. |
미소장 |
| 7 | Heterogeneity of chemosensitivity of metastatic cutaneous melanoma. |
미소장 |
| 8 | Correlation of drug response with the ATP tumorchemosensitivity assay in primary FIGO stage III ovarian cancer. |
미소장 |
| 9 | Kurbacher CM, Cree IA, Brenne U, Bruckner HW, Kurbacher JA, Mallmann P, Andreotti PE, Krebs D. Heterogeneity of in vitro chemosensitivity in perioperative breast cancer cells to mitoxantrone versus doxorubicin evaluated by a microplate ATP bioluminescence assay. Breast Cancer Res Treat 1996; 41: 161-70. | 미소장 |
| 10 | In vitro drug sensitivity predicts response and survival after individualized sensitivity-directed chemotherapy in metastatic melanoma: a multicenter phase II trial of the Dermatologic Cooperative Oncology Group. |
미소장 |
| 11 | A feasibility study of adenosine triphosphate-based chemotherapy response assay (ATP-CRA) as a chemosensitivity test for lung cancer. | 소장 |
| 12 | Adenosine triphosphate‐based chemotherapy response assay (ATP‐CRA)‐guided platinum‐based 2‐drug chemotherapy for unresectable nonsmall‐cell lung cancer |
미소장 |
| 13 | Predictive value of individualized tumor response testing by ATP-based chemotherapy response assay in ovarian cancer. |
미소장 |
| 14 | The use of an in vitro adenosine triphosphate-based chemotherapy response assay to predict chemotherapeutic response in breast cancer |
미소장 |
| 15 | In Vitro Chemosensitivity Testing of Human Non-Small Cell Lung Cancer Cell Lines |
미소장 |
| 16 | Pharmacological study of paclitaxel duration of infusion combined with GFR-based carboplatin in the treatment of ovarian cancer. |
미소장 |
| 17 | Reporting results of cancer treatment. |
미소장 |
| 18 | Correlation of the clinical response to chemotherapy in breast cancer with ex vivo chemosensitivity. |
미소장 |
| 19 | Use of an ex vivo ATP luminescence assay to direct chemotherapy for recurrent ovarian cancer. |
미소장 |
| 20 | Application of an ATP-bioluminescence assay in human tumor chemosensitivity testing |
미소장 |
| 21 | Enhanced ex vivo drug sensitivity testing of chronic lymphocytic leukaemia using refined DiSC assay methodology. |
미소장 |
| 22 | Predictive value of the ATP chemosensitivity assay in epithelial ovarian cancer. |
미소장 |
| 23 | Understanding sensitivity and specificity with the right side of the brain |
미소장 |
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