대표어
한국학술지인용색인(NRF)
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Background : Making the diagnosis of the follicular variant of papillary thyroid carcinoma (FVPTC) is often difficult, and there are no accurate immunohistochemical or molecular markers. The purpose of this study is to evaluate performing immunohistochemistry to make the diagnosis of FVPTC. Methods : A total of 249 thyroid lesions were studied. We made the tissue microarray, and we assessed the expression of HBME-1, galectin-3, CD56, and p63. Results : Galectin-3, HBME-1, and p63 were positive in 79.7%, 79.7%, and 15.9% of the FVPTC, respectively. These immunohistochemical features of FVPTC were between those of classic papillary thyroid carcinoma (CPTC) and those of non-PTC. The CD56 expression was positive in 75.4% of the FVPTC, which is much higher than that of the CPTC (28.3%), and even higher than that of the non-PTC lesions (60%). Comparing FVPTC with CPTC, the expression of galectin-3 was significantly higher and the expression of CD56 was significantly lower in the CPTCs. Comparing the FVPTC with follicular carcinoma (FC), the expression of all the markers was significantly higher in the FVPTC. Comparing PTC with FC, the expression of CD56 was lower and the expressions of the other markers were higher in the PTCs. Conclusions : Galectin-3, HBME-1, and p63 can help make the diagnosis of FVPTC, and a cocktail of these markers can be even more useful. But CD56 is not thought to be useful to make the diagnosis of FVPTC.
권호기사
참고문헌 (27건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling | 미소장 |
| 2 | Pure versus follicular variant of papillary thyroid carcinoma | 미소장 |
| 3 | Immunohistochemical Expression of Galectin-3 in Benign and Malignant Thyroid Lesions | 미소장 |
| 4 | NCAM regulates cell motility | 미소장 |
| 5 | The p53/p63/p73 family of transcription factors: overlapping and distinct functions | 미소장 |
| 6 | Usefulness of HBME‐1, cytokeratin 19 and galectin‐3 immunostaining in the diagnosis of thyroid malignancy | 미소장 |
| 7 | Application of CD56, P63 and CK19 immunohistochemistry in the diagnosis of papillary carcinoma of the thyroid | 미소장 |
| 8 | Immunohistochemical detection of p53 homolog p63 in solid cell nests, papillary thyroid carcinoma, and hashimoto’s thyroiditis: a stem cell hypothesis of papillary carcinoma oncogenesis | 미소장 |
| 9 | Differential reactivity of HBME-1 and CD15 antibodies in benign and malignant thyroid tumours | 미소장 |
| 10 | P63 Expression in Papillary and Anaplastic Carcinomas of the Thyroid Gland: Lack of an Oncogenetic Role in Tumorigenesis and Progression | 미소장 |
| 11 | Expression of the GLUT1 glucose transporter, p63 and p53 in thyroid carcinomas | 미소장 |
| 12 | Immunopathologic and molecular studies as an aid to the diagnosis of malignant mesothelioma | 미소장 |
| 13 | Papillary carcinoma of the thyroid: low expression of NCAM (CD56) is associated with downregulation of VEGF‐D production by tumour cells | 미소장 |
| 14 | Expression of p63 in papillary thyroid carcinoma and in Hashimoto’s thyroiditis: a pathobiologic link? | 미소장 |
| 15 | Observer Variation in the Diagnosis of Follicular Variant of Papillary Thyroid Carcinoma | 미소장 |
| 16 | Quantifying the Value of In-house Consultation in Surgical Pathology | 미소장 |
| 17 | Papillary and follicular variant of papillary carcinoma of the thyroid: Initial presentation and response to therapy | 미소장 |
| 18 | Why There Is the Tendency to “Overdiagnose” the Follicular Variant of Papillary Thyroid Carcinoma | 미소장 |
| 19 | Diagnostic Value of Galectin-3, HBME-1, Cytokeratin 19, High Molecular Weight Cytokeratin, Cyclin D1 and p27kip1 in the Differential Diagnosis of Thyroid Nodules | 미소장 |
| 20 | Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors | 미소장 |
| 21 | Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule. | 미소장 |
| 22 | Strict Criteria Should Be Applied in the Diagnosis of Encapsulated Follicular Variant of Papillary Thyroid Carcinoma | 미소장 |
| 23 | Follicular-Patterned Lesions of the Thyroid | 미소장 |
| 24 | Protein and mRNA Expression of CD56/N-CAM on Follicular Epithelial Cells of the Human Thyroid | 미소장 |
| 25 | Neural cell adhesion molecule (N-CAM) in gastrointestinal neoplasias. | 미소장 |
| 26 | The relation between pure papillary and follicular variant in papillary thyroid carcinoma. | 미소장 |
| 27 | Galectin-3 as a multifunctional protein. | 미소장 |
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