한국학술지인용색인(NRF)
권호기사보기
| 기사명 | 저자명 | 페이지 | 원문 | 기사목차 |
|---|
국회도서관 홈으로
정보검색
소장정보 검색
결과 내 검색
동의어 포함
저자 검색
- 검색종류
| 대표형(전거형, Authority) | 생물정보 | 이형(異形, Variant) | 소속 | 직위 | 직업 | 활동분야 | 주기 | 서지 | |
|---|---|---|---|---|---|---|---|---|---|
| 연구/단체명을 입력해주세요. | |||||||||
관련 키워드 검색
- 대표어
- 외국어
|
|
|
|
|
|
주제별 검색
* 주제를 선택하시면 검색 상세로 이동합니다.
초록보기
This study was conducted to investigate the effects of blueberry extract on cell death, ROS and gene expression patterns associated with the anti-cancer activity in human breast cancer MCF7 cells. To accomplish this, 20 mg/mL concentration of blueberry extract was added to the cell culture for 0, 6, 12, 24 or 48 h, after which the effects were evaluated by various analyses. MTT assay showed that the cellular activities decreased rapidly during the first 12 h of treatment. During this period, dual staining with Hoechst33322 and propidium iodide also produced a similar trend in which the dead or dying cells increased sharply. Furthermore, evaluation of BrdU incorporation as an index for cell proliferation revealed a marked decrease during the first 12 h of treatment, suggesting that anticancer activity involves the inhibition of cell proliferation and induces cell death. ROS also increased according to the duration of the treatment, indicating intracellular accumulation is associated with the cell death. RT-PCR analysis revealed significant decreases in anti-apoptotic (Bax) and increases in pro-apoptotic gene expressions (Bcl-2, caspase- 3, and 9) (p<0.05). Taken these together, blueberry extract induces ROS accumulation in MCF7 cells, causing inhibition of cell proliferation and eventually leading to cell death. This cell death was associated with apoptotic gene expression in blueberry-treated cells for up to 24 h.
권호기사
참고문헌 (32건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Adams JM, Cory S (1998) The Bcl-2 protein family: Arbiters of cell survival. Science 281: 1322-1326. | 미소장 |
| 2 | Akoh CC, Yi W, Fischer J, Krewer G (2005) Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. J Agric Food Chem 53:7320-7329. | 미소장 |
| 3 | Antonsson B, Montessuit S, Sanchez B, Martinou JC (2001) Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. J Bio Chem 276: 11615-11623. | 미소장 |
| 4 | Bagchi D, Sen CK, Bagchi M, Atalay M (2004) Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochem 69:75-80. | 미소장 |
| 5 | Borek C, Labriola D, Livingston R (2004) Dietary antioxidants and human cancer. Inter Cancer Ther 3: 333-341. | 미소장 |
| 6 | Budihardjo I (1999) Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Bio l15: 269-290. | 미소장 |
| 7 | Budihardjo I, Oliver H, Lutter M, Luo X, Wang X (2004)Chemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Bio l15: 269-290. | 미소장 |
| 8 | Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 23: 205-219. | 미소장 |
| 9 | Giovannucci E, Stampfer MJ, Colditz G, Rimm EB, Willett WC (2005) Diet and cancer an evolving picture. JAMA 293:233-234. | 미소장 |
| 10 | Jhons T, Romeo JT (1999) Functionality of food phytochemicals. Recent Adv Phytochem 33: 133-159. | 미소장 |
| 11 | Kelsey JL (1998) Breast cancer epidemiology. Cancer Res 48:5615-5623. | 미소장 |
| 12 | Korea National Statistic Office (2005) The Korean cause of death. | 미소장 |
| 13 | Lee SN, Kim KH, Kang KJ (2009) The effect of blueberry on the ROS and apotosis in human breast cancer MCF7 cells. Plant Resou Res Institute Duksung Women’s University 8: 51-67. | 미소장 |
| 14 | Malik AS, Afaq F, Sarfaraz S, Adhami VM, Syed DN, Mukhtar H (2005) Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. PNAS 102:14813-14818. | 미소장 |
| 15 | Ministry of Health and Welfare (2005) 한국인 암 등록 조사 자료 분석보고서. 5-7. | 미소장 |
| 16 | Nakamura J, Purvis ER, Swenberg JA (2003) Micromolar concentrations of hydrogen peroxide induce oxidative DNA lesions more efficiently than millimolar concentrations in mammalian cells. Nucleic Acids Res 31: 1790-1795. | 미소장 |
| 17 | Nkondjock A, Ghadirian P (2005) Risk factors and risk reduction of breast cancer. Med Sci 21: 175-180. | 미소장 |
| 18 | Olsson ME, Gustavsson KE, Andersson SF, Nilsson A, Duan RD (2004) Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J Agri Food Chem 52: 7264-7271. | 미소장 |
| 19 | Cell  |
미소장 |
| 20 | Osford SM, Dallman CL, Jhonson PW, Ganesan A, Packham G (2004) Current strateigs to target the anti-apoptosis Bcl-2 protein I n cancer cells. Cuee Med Chem 11: 1031-1039. | 미소장 |
| 21 | Reed JC (1997) Double identity for proteins of the Bcl-2 family. Nature 387: 773-776. | 미소장 |
| 22 | Cell |
미소장 |
| 23 | Sahinoglu T, Stevens CR, Bhatt B, Sahinoglu T (1996) The role of reactive oxygen species in inflammatory disease: Evaluation of methodology. Enzymology 9: 628-634. | 미소장 |
| 24 | Seeram NP, Adams LS, Zhang YJ, Lee RP, Sand DN. Scheuller HS, Heber DV (2006) Blackberry, black raspberry, blueberry, cranberry, red raspberry and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agri Food Chem 54: 9329-9339. | 미소장 |
| 25 | Shih PH, Gow-Chin Y (2005) Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells. Food Chem Toxicol 43: 1557-1566. | 미소장 |
| 26 | Smith MAL, Marley KA, Seigler DA, Singletary KW, Meline B (2000) Bioactive properties of wild blueberry fruits. J Food Sci 65: 352-356. | 미소장 |
| 27 | Smith SH, Tate PL, Huang G, Magee JB, Meepagala KM, Wedge DE, Larcom LL (2004) Antimutagenic activity of berry extracts. J Med Food 7: 450-455. | 미소장 |
| 28 | Sun J, Liu RH (2006) Cranberry phytochemical extracts induce cell cycle arrest and apotosis in human MCF-7 breast cancer cells. Cancer Letters 241: 124-134. | 미소장 |
| 29 | Vokkala M, Paakko P, Soini Y (1999) Expression of caspase 3, 6, and 8 is increased in parallel with apoptosis and histological aggresiveness of the breast lesion. Br J Cancer 81: 592-599. | 미소장 |
| 30 | Wang X, Yuan S, Wang J, Lin P, Liu G, Lu Y, Zhang J, Wang W, Wei Y (2006) Anticancer activity of litchi fruit pericarp extract against human breast cancer in vitro and in vivo. Toxicol Appl Pharm 215: 168-178. | 미소장 |
| 31 | Wedge DE, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL (2001) Anticarcinogenic activity of strawberry, blueberry, and raspberry extracts to breast and cervical cancer cells. J Med Food 4: 49-52. | 미소장 |
| 32 | Yang XH, Edgerton S, Thor AD (2001) Reconstitution of caspase-3 sensitizes MCF-7 breast cancer cells to radiation therapy. J Oncol 26: 62-73. | 미소장 |
MARC 보기
오류 데이터 정정요청
*표시는 필수 입력사항입니다.
알림톡 발송
| *전화번호 | ※ '-' 없이 휴대폰번호를 입력하세요 |
|---|
연속간행물 권호 선택
우편복사 안내
- ◾ 도서관을 방문하지 못할 경우 인터넷, 팩스 등으로 자료 복사를 신청하고, 복사물을 우편·팩스 등으로 제공받는 서비스
- ◾ 대상자료: 일반도서, 연속간행물 및 학위논문
- ※ 고서, 고잡지, 훼손될 우려가 있는 자료, 마이크로폼 자료 및 신문 등 제외
- ◾ 신청 책수: 1인 5책 이하(1일 기준)
- ◾ 신청 절차: 자료 검색 → 우편복사 목록담기 → 복사 범위 입력 → 우편복사 주문서 입력 → 접수 및 확인
- ※ 저작권법에 의거하여 부분 복사(전체 페이지 수의 1/3 범위 이내)만 가능
- ◾ 복사 범위 입력 예시: (연속 페이지) 1-30, (부분 페이지) 25, 30-40
| 번호 | 발행일자 | 권호명 | 제본정보 | 자료실 | 원문 | 신청 페이지 |
|---|
도서위치안내(서울관)
도서위치안내: 정기간행물실(524호) / 서가번호: 국내04
2021년 이전 정기간행물은 온라인 신청(원문 구축 자료는 원문 이용)
0
확인
우편복사 목록담기를 완료하였습니다.
내서재에 담기
새로운 서재
*표시는 필수 입력사항입니다.
저장
저장 되었습니다.