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The purpose of this study was to investigate the long-term effects of exercise under intermittent hypoxic condition on hematological parameters and antioxidant potential in mice. For the present study, mice were divided into four groups: normoxia (21% oxygen) control(NC), hypoxia (13% oxygen) control(HC), normoxia exercise (20 m/min, 40 min/day, 3 times/week for 10 weeks) (NE), and hypoxia exercise (HE) group. The study indicated that hemoglobin
was significantly increased only in the NE and HC groups. Furthermore, the mean corpuscular volume had significantly decreased in the HE group. Basal blood lactate levels were similar in all four groups and were increased by exercise. However, the increasement was lesser in the exercise groups. Furthermore, the minimal increasement was observed in the HE group. The production of free radicals in the blood was decreased by either exercise or exposure to intermittent hypoxic condition. Also, the antioxidant potential was increased by exercising. The results of this study suggest that subjecting mice to intermittent hypoxia condition or exercise may influence the oxygen transportation and antioxidant potential in their blood.권호기사
참고문헌 (42건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Robert SM: Altitude, exercise and immune function. Exerc Immunol Rev, 11:6-16, 2005. | 미소장 |
| 2 | High-Altitude Training  |
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| 3 | Effects of iron supplementation on total body hemoglobin during endurance training at moderate altitude. |
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| 4 | Individual variation in response to altitude training. |
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| 5 | Terrados N, Melichna J, Sylven C, Jannson E, Kaijser L: Effects of training at stimulated altitude on performance and muscle. J Appl Physiol, 56:1187-1190, 1988. | 미소장 |
| 6 | The effect of altitude on cycling performance: a challenge to traditional concepts. |
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| 7 | Effects of training in normoxia and normobaric hypoxia on human muscle ultrastructure. |
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| 8 | Is hypoxia a stimulus for synthesis of oxidative enzymes and myoglobin? |
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| 9 | Training in hypoxia vs. training in normoxia in high-altitude natives. |
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| 10 | Increased blood ammonia in hypoxia during exercise in humans |
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| 11 | Sea-level exercise performance following adaptation to hypoxia: a meta-analysis. |
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| 12 | Halliwell B, Gutteridge JMC: Free radicals in biology and medicine. Oxford, UK: Clarendon Press, 2007. | 미소장 |
| 13 | Exercise, oxidative stress and hormesis |
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| 14 | Diem K, Lentner C: Scientific tables. Documenta geigy. Basel, Switzerland geigy, 1970. | 미소장 |
| 15 | Electron spin resonance studies of intact mammalian skeletal muscle. |
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| 16 | Glutathione and antioxidant enzymes in skeletal muscle: effects of fiber type and exercise intensity. |
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| 17 | Davied KJ, Quintanilha AT, Brooks GA, Packer GA: Free radical and tiwwue damage peroduced by exercise. Biochem Biophys Res Commun, 107:1198-1205, 1982. | 미소장 |
| 18 | Measurement of serum lipid peroxidation during exercise using three different methods: diene conjugation, thiobarbituric acid reactive material and fluorescent chromolipids |
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| 19 | Kilboum JF: Shrinkage necrosis: a distinct mode of cellular death. J Pathol, 105:13029, 1990. | 미소장 |
| 20 | Exercise-induced oxidative stress: glutathione supplementation and deficiency. |
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| 21 | Superoxide dismutase and catalase in skeletal muscle: adaptive response to exercise. |
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| 22 | Quintanilha AT: The effect of physical exercise and/or vitamin E on tissue oxidative metabolism. Bichemical Society Transactions, 12(3):403-404, 1984. | 미소장 |
| 23 | MDA content increases in fast- and slow-twitch skeletal muscle with intensity of exercise in a rat. |
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| 24 | Skeletal muscle oxidative capacity, antioxidant enzymes, and exercise training |
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| 25 | High-altitude illness. |
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| 26 | Blood gas transport properties in endurance-trained athletes living at different altitudes. |
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| 27 | Effects of intermittent hypoxia on pulmonary haemodynamics: animal models versus studies in humans. |
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| 28 | Acta Physiologica Scandinavica changes its name to Acta Physiologica and OnlineEarly is adopted |
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| 29 | HIF-1 and human disease: one highly involved factor. |
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| 30 | Physiological effects of intermittent hypoxia. |
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| 31 | Banister EW, Woo W: Effects of simulated altitude training on aerobic and anaerobic power. Eur J Appl Physiol, 38:55-69, 1978. | 미소장 |
| 32 | Endurance training affects lactate clearance, not lactate production. |
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| 33 | Nattie EE, Doble EA: Threshold of intermittent hypoxiainduced right ventricular hypertrophy in the rat Respir. Physiol, 56:253-259, 1984. | 미소장 |
| 34 | Nitrendipine attenuates the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia in rats. |
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| 35 | Red blood cell function in hypoxia at altitude and exercise. |
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| 36 | Devi SA, Vani R, Subramanyam MV, Reddy SS, Jeevaratnam K: Intermittent hypobaric hypoxia-induced oxidative stress in rat erythrocytes: protective effects of vitamin E, vitamin C, and carnitine. Cell Biochem Funct, 5:221-231, 2007. | 미소장 |
| 37 | The hypoxic stress on erythrocytes associated with superoxide formation. |
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| 38 | Mazzeo RS, Brooks GA, Butterfield GE: β-adrenergic blockade does not prevent the lactate response to execise after acclimatization. J Appl Physiol, 76:610-615, 1994. | 미소장 |
| 39 | Metabolic and work efficiencies during exercise in Andean natives |
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| 40 | Erythrocyte free radical scavenger enzymes in bicycle professional racers. Adaptation to training. |
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| 41 | Influence of exercise on clearance of oxidant stress products and loosely bound iron. |
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| 42 | Strenuous endurance training in humans reduces oxidative stress following exhausting exercise |
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