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표고버섯균사체 고체배양물 분말과 액체배양물 분말을 2:1 (w/w)로 혼합한 시료 (LED로 명명)가 CCl4로 유발된 숫컷 쥐의 간독성을 보호하는 효과에 대해 연구하였다. Vehicle 처리군(0.2 ml 증류수), Control 처리군(0.2 ml 증류수), LED 처리군(LED 100, 200, 300, 400 mg/kg BW을 0.2 ml 증류수에 각각 혼합), 그리고 Silymarin 처리군(200 mg/kg을 0.2 ml 증류수에 용해)의 각 처리군(군당 여섯 마리)에 매일 2주간 투여한 다음, Vehicle 처리군을 제외한 모든 군에 CCl4 (CCl4:corn oil, 1:1 v/v; 0.5 ml/kg BW)를 복부에 주사하였다. 하루가 지난 후에 생화학적 지표성분을 분석하기 위해 혈액과 간 시료를 채취하였다. 모든 LED 처리에 의해 간 SOD, catalase, 그리고 GSH peroxidase의 활성이 증가하였으며, TBARS, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) 그리고 interleukin-6 (IL-6)가 감소하였다. 그 결과, 혈청중의 GOT, GPT, 그리고 LDH의 활성이 감소하였다. LED의 간 기능 보호효과가 가장 효과적으로 나타난 처리농도는 200 mg/kg BW였다. 이러한 결과로 보아 LED는 CCl4로 유발된 SD 쥐의 간 손상을 보호하며, 이는 LED의 항산화능과 cytokine의 감소에 의한 것이다. 따라서, LED는 사람의 간독성보호를 위해 효과적으로 사용할 수 있을 것으로 생각된다.
The protective effects of a powder mixed with solid-cultured and liquid-cultured Lentinus edodes mycelia (2 : 1, w/w) (designate LED) with different doses of carbon tetrachloride (CCl4) on induced hepatotoxicity in male Sprague-Dawley (SD) rats was investigated. The rats were divided into seven groups (6 rats/group) and the following substances were administered orally to each group: Vehicle (0.2 ml distilled water), Control (0.2 ml distilled water), LED (LED 100, 200, 300 and 400 mg/kg BW in 0.2 ml distilled water), and Silymarin (200 mg/Kg BW in 0.2 ml distilled water). After two weeks of daily administration, all groups except for the Vehiclegroup were subjected to abdominal injection with CCl4 (CCl4 : corn oil, 1 : 1 v/v; 0.5 ml/kg BW). One day later, blood and liver samples were collected to analyze biomarkers. All LED treatments elevated hepatic superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH peroxidase) activities, and reduced thiobarbituric reactive substances (TBARS), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), resulting in the reduction of glutamate-oxalate transaminase (GOT), glutamate-pyruvate transaminase (GPT) and lactic acid dehydrogenase (LDH) activities in plasma. These results indicate that LED effectively protected SD rat hepatotoxicity induced by CCl4 through its antioxidative activity and reduction of some cytokines. The highest efficacy was found in LED 200 mg/kg BW, showing potential as a useful material for protection from hepatotoxicity in humans.
The protective effects of a powder mixed with solid-cultured and liquid-cultured Lentinus edodes mycelia (2 : 1, w/w) (designate LED) with different doses of carbon tetrachloride (CCl4) on induced hepatotoxicity in male Sprague-Dawley (SD) rats was investigated. The rats were divided into seven groups (6 rats/group) and the following substances were administered orally to each group: Vehicle (0.2 ml distilled water), Control (0.2 ml distilled water), LED (LED 100, 200, 300 and 400 mg/kg BW in 0.2 ml distilled water), and Silymarin (200 mg/Kg BW in 0.2 ml distilled water). After two weeks of daily administration, all groups except for the Vehiclegroup were subjected to abdominal injection with CCl4 (CCl4 : corn oil, 1 : 1 v/v; 0.5 ml/kg BW). One day later, blood and liver samples were collected to analyze biomarkers. All LED treatments elevated hepatic superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH peroxidase) activities, and reduced thiobarbituric reactive substances (TBARS), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), resulting in the reduction of glutamate-oxalate transaminase (GOT), glutamate-pyruvate transaminase (GPT) and lactic acid dehydrogenase (LDH) activities in plasma. These results indicate that LED effectively protected SD rat hepatotoxicity induced by CCl4 through its antioxidative activity and reduction of some cytokines. The highest efficacy was found in LED 200 mg/kg BW, showing potential as a useful material for protection from hepatotoxicity in humans.
권호기사
참고문헌 (31건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
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| 2 | Carbon Tetrachloride-Induced Hepatotoxicity: Protective Effect of 'Rocket' Eruca sativa L. in Rats  |
미소장 |
| 3 | Bio-Rad Laboratories, Inc. 2008. Quick Start Bradford Protein Assay, Hercules, CA. | 미소장 |
| 4 | Hydroperoxide metabolism in mammalian organs. |
미소장 |
| 5 | Rikans, L. E., L. A. DeCicco, K. R. Hornbrook, and T. Yamano. 1999. Effect of age and carbon tetrachloride on cytokine concentrations in rat liver. Mech. Ageing Devel. 108, 173-182. | 미소장 |
| 6 | Efficacy of orally administered superfine dispersed lentinan (beta-1,3-glucan) for the treatment of advanced colorectal cancer. |
미소장 |
| 7 | A simple method for the isolation and purification of total lipides from animal tissues. |
미소장 |
| 8 | Critical role of lipid peroxidation in carbon tetrachloride-induced loss of aminopyrine demethylase, cytochrome P-450 and glucose 6-phosphatase |
미소장 |
| 9 | Ha, Y. L., Y. S. Kim, C. R. Ahn, J. M. Kweon, C. W. Park, Y. K. Ha, and J. O. Kim. 2010. Mycelial culture of Lentinus edodes alleviates rat liver toxicity induced by carbon tetrachloride and ethanol. J. Life Sci. 20, 133-141. | 미소장 |
| 10 | Han, S. H., J. B. Kim, S. G. Min, and C. H. Lee. 1995. The effects of Puerariae Radix catechins administration on liver function in carbon tetrachloride-treated rats. J. Korean Soc. Food Nutr. 24, 713-719. | 미소장 |
| 11 | Hayes. 1982. Principles and methods of toxicology. pp. 407. Raven Press. New York. | 미소장 |
| 12 | Hobbs, C. 2000. Medicinal value of Lentinus edodes (Berk) Sing (Agaricomycetideae). A literature review. Int. J. Med. Mushrooms 2, 287-302. | 미소장 |
| 13 | Production of Lentinus edodes Mycelia Extracts (LEM) |
미소장 |
| 14 | Kim, K. S., S. Y. Chung, and S. W. Kim. 1993. The effect of selenium and vitamin E on activity of enzyme related to the lipid peroxidation in rat with alcohol administration. J. Korean Soc. Food Nutr. 22, 116-126. | 미소장 |
| 15 | Kim, S. K. and S. Y. Chung. 1992. Effects of feeding the mixed oils of butter, sardine and safflower on the lipid components in serum and activities of hepatic functional enzymes in rats. J. Korean. Soc. Food Nutr. 21, 608-616. | 미소장 |
| 16 | Korea Food & Drug Administration. 2008. Health Functional Food Code, pp. 130-131. Standards of Health Functional Food Ⅲ. 3.4.3, Republic of Korea. | 미소장 |
| 17 | Glutathione peroxidase activity in selenium-deficient rat liver |
미소장 |
| 18 | Morin protects acute liver damage by carbon tetrachloride (CCl) in rat | 소장 |
| 19 | Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. |
미소장 |
| 20 | Effect of 3-methylcholanthrene induction on the carbon tetrachloride-induced changes in rat hepatic microsomal enzyme system |
미소장 |
| 21 | Mizuno, T. 1995. Mushrooms: the versatile fungus-food and medicinal properties. Food Rev. Int. 11 (Issue 1), 1-235. | 미소장 |
| 22 | Morinaga, H., K. Tazawa, H. Tagoh, A. Muraguchi, and M. Fujimaki. 1994. An in vivo study of hepatic and splenic interleukin-1 beta mRNA expression following oral PSK or LEM administration. Jpn. J. Cancer Res. 85, 1298-1303. | 미소장 |
| 23 | The critical steady-state hypoxic conditions in carbon tetrachloride-induced lipid peroxidation in rat liver microsomes. |
미소장 |
| 24 | Park. P. S., B. L. Lee, and M. Y. Lee. 1991. Effect of onion diet on carbon tetrachloride toxicity of rats. J. Korean Soc. Food Nutr. 20. 121-125. | 미소장 |
| 25 | Ross, G. D., V. Vetvicka, J. Yan, Y. Xia, and J. Vetickova. 1999. Therapeutic intervention with complement and beta-glucan in cancer. Immunophamacology 42, 61-74. | 미소장 |
| 26 | Surendra, V., T. Prakash, U. R. Sharma, D. Goli, S. D. Fadadu, D. Kotresha. 2008. Hepatoprotective activity of aerial parts of Cynodon dactylon against CCl4-induced in rats. Phcog. Mag. 4 (16 SUPPL.), S195-S201. | 미소장 |
| 27 | Terada, H., T. Ohara, Y. Yamaguchi, T. Ueda, and K. Asano. 2001. Protective effects of the Lentinus edodes mycelia on carbon tetrachloride induced liver injury. J. New Rem. Clin. 50, 655-664. | 미소장 |
| 28 | Thomas, M., S. Leelamma, and P. A. Kurup. 1983. Effect of blackgram fiber (Phaseolus mungo) on cholesterol genesis and cholesterol degeneration in rats. J. Nutr. 113, 1104-1108. | 미소장 |
| 29 | Tsubura, E., M. Nishimoto, and K. Nishii. 1999. Effects of LEM (Lentinus edodes mycelia) for chemotherapy. Prog. Med. 19, 129-134. | 미소장 |
| 30 | Immunopotentiating Activity of the Water-soluble Lignin Rich Fraction Prepared from LEM-The Extract of the Solid Culture Medium of Lentinus edodes Mycelia- |
미소장 |
| 31 | The shiitake mushroom-derived immuno-stimulant lentinan protects against murine malaria blood-stage infection by evoking adaptive immune-responses |
미소장 |
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