대표어
한국학술지인용색인(NRF)
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|---|
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Purpose
With their prolonged survival and malnutrition, cancer patients, and especially gastrointestinal (GI) tract cancer patients, can develop Wernicke’s encephalopathy (WE). The aim of this study is to remind physicians of the importance of WE and prompt management in patients with GI tract cancer.
Materials and Methods
This study is a retrospective review of 2 cases of WE in advanced gastric cancer (AGC) patients, and we review the literature for cases of GI tract cancer related to WE.
Results
A 48-year-old female with AGC presented dizziness and diplopia for 5 days and a 20 kg weight loss. Neurologic exam showed nystagmus and gaze disturbance. Her symptoms improved after daily parenteral injection of thiamine 100 mg for 17 days. A 58-year-old female with AGC presented with sudden disorientation, confusion and 15 kg weight loss. Neurologic exam showed gaze limitation and mild ataxia. Despite daily parenteral injection of thiamine 100 mg for 4 days, she died 5 days after the onset of neurologic symptoms. Combining the cases noted in the literature review with our 2 cases, the 7 gastric cancer cases and 2 colorectal cancer cases related to WE showed similar clinical characteristics; 1) a history of long-period malnutrition and weight loss, 2) relatively typical neurologic signs and symptoms and 3) specific magnetic resonance image findings. Except for 2 patients who had irreversible neurologic symptoms, the other 7 patients were improved with prompt thiamine treatment.
Conclusion
It is important to consider WE in GI tract cancer patients with acute neurologic symptoms and who are in a state of malnutrition. Thiamine should be given as soon as possible when WE is suspected.권호기사
참고문헌 (20건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Victor M, Adams RD, Collins GH. The Wernicke-Korsakoff syndrome. A clinical and pathological study of 245 patients, 82 with post-mortem examinations. Contemp Neurol Ser. 1971;7:1-206. | 미소장 |
| 2 | Thiamin Deficiency and Korsakoff's Syndrome  |
미소장 |
| 3 | Wernicke's encephalopathy in non-alcoholics |
미소장 |
| 4 | Wernicke Encephalopathy in Nonalcoholic Patients |
미소장 |
| 5 | Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management |
미소장 |
| 6 | Thiamine-responsive acute neurological disorders in nonalcoholic patients. |
미소장 |
| 7 | Reversible impairment of cerebral DNA synthesis in thiamine deficiency. |
미소장 |
| 8 | Wernicke's encephalopathy: a more common disease than realised. A neuropathological study of 51 cases. |
미소장 |
| 9 | Wernicke C. Lehrbuch der gehirnkrankheiten für aerzte und studirende. Kassel Theodor Fischer. 1881;2:229-42. | 미소장 |
| 10 | Ropper A, Brown R. Adams and Victor’s Principles of Neurology. 8th ed. New York: McGraw-Hill; 2005. | 미소장 |
| 11 | Fluorouracil-induced neurotoxicity. |
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| 12 | Acute Encephalopathy Attributed to 5-FU |
미소장 |
| 13 | Intermediate dose 5-fluorouracil-induced encephalopathy. |
미소장 |
| 14 | Korea National Statistical Office, National database of cancer (1999-2002): Annual report of statistisc of death causes. Seoul: Korea National Statistical Office; 2005. | 미소장 |
| 15 | Severe acute metabolic acidosis and Wernicke's encephalopathy following chemotherapy with 5-fluorouracil and cisplatin: case report and review of the literature. |
미소장 |
| 16 | Diffusion-weighted imaging in Wernicke encephalopathy associated with stomach cancer: case report and review of the literature. |
미소장 |
| 17 | Successful treatment of Wernicke encephalopathy in terminally ill cancer patients: Report of 3 cases and review of the literature |
미소장 |
| 18 | Wernicke’s Encephalopathy following Gastrectomy in Patients with Gastric Cancer | 소장 |
| 19 | Wernicke's encephalopathy in a malnourished surgical patient: clinical features and magnetic resonance imaging |
미소장 |
| 20 | Magnetic resonance imaging in a case of Wernicke's encephalopathy. |
미소장 |
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