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The low butanol tolerance of most microorganisms severely limits the production of 1-butanol

on an economical scale in alternative hosts other than the natural butanol producer Clostridium

acetobutylicum, which is not amenable for genetic manipulation and requires demanding culture

conditions. To generate butanol-tolerant E. coli, we devised a cyclic selection strategy that consists

of an iterative application of proton irradiation at a dose of ~250 Gy by using 45-MeV protons and

selection by daily serial transfer in a minimal medium containing increasing concentrations of 1-

butanol. Applying five rounds of the cyclic selection of E. coli ATCC 8739 (a C strain) over 61 days

resulted in a mutant population that could tolerate 1.2% 1-butanol (v/v). However, without proton

irradiation, the cells were unable to grow at ≥0.8% 1-butanol in a control experiment. Seven

different mutations were identified within one clone from the endpoint population through 454

pyrosequencing of the genome. Tracing each mutation in terms of the prevalence in the population

during the period of evolution suggested that proton beam irradiation-induced mutations were

rapidly fixed during the early phase of the selection procedure. This approach, which is still being

applied to increase butanol tolerance beyond 1.3%, can be considered useful for improving targeted

traits whose corresponding genes are unknown.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Status repot of J-PARC Nobuo Ouchi pp.1921-1927

(The)Compact pulsed hadron source : a design perspective Jie Wei ; Huaibi Chen ; Cheng Cheng ; Qiang Du ; Taibin Du ; Zhe Feng ; Xialin Guan ; Xiaoxue Han ; Tuchen Huang ; Renkai Li ; Wenqian Li ; Chun K. Loong ; Beibei Shao ; Chuanxiang Tang ; Qingzi Xing ; Yigang Yang ; Hao Zha ; Huayi Zhang ; Shuxin Zheng ; Bin Zhong ; Shinian Fu ; Juzhou Tao ; Yaliang Zhao ; Tianjiao Liang ; Liangting Sun ; Hongwei Zhao ; Jinhai Li ; Qixi Feng ; Takeshi Kawai ; Guohua Li ; Dongsheng Zhang pp.1928-1935

(The)Proton engineering frontier project : accelerator development Kui Young Kim ; Yong-Sub Cho ; Jun Yeon Kim ; Kye Ryung Kim ; Byung-Ho Choi pp.1936-1943

Electron cloud instability at Cser-TA H. Jin ; M. Yoon ; K. Ohmi pp.1944-1946

Magnet design of a proton and carbon-ion synchrotron for cancer therapy Hyung-Suck Suh ; Young-Gyu Jung ; Heung-Sik Kang pp.1947-1952

Validity of using the photo-cathode gun for a compact X-ray free-electron laser Tae-Yeon Lee ; Hung-Sik Kang pp.1953-1956

Effects of the resistive wall impedance in the PLS-Ⅱ storage ring Su-Youn Lee ; Ji-Gwang Hwang ; Eun-San Kim pp.1957-1959

Development of a beam buncher for the KIRAMS-30 cyclotron In Su Jung ; Gun Uk Kang ; Dong Hyun An ; Garam Hahn ; Joon Sun Kang ; Bong Hwan Hong ; Hong Suk Chang ; Hee Joong Yim ; Geun-Beom Kim ; Yeunsoo Park ; Tea Gun Yang ; Jun Dong Cho ; Key Ho Kwon pp.1960-1963

Status of the PLS-Ⅱ magnet design and fabrication D. E. Kim ; K. H. Park ; H. G. Lee ; H. S. Han ; Y. G. Jung ; H. S. Suh ; Y. D. Joo ; K. R. Kim pp.1964-1970

Shielding design for the target room of the proton accelerator research center Y. S. Min ; C. W. Lee ; K. J. Mun ; J. Nam ; Jun Yeon Kim pp.1971-1980

Photon-beam-position monitor in the PLS diagnostic beamline Changbum Kim ; Jong Chel Yoon ; Seung-nam Kim ; Myong-jin Kim ; Hee Seob Kim ; Chun Kil Ryu ; Chae-soon Lee ; In Deuk Seo ; Chongdo Park ; Hae Cheol Lee ; Man-soo Hong ; Jung-Yun Huang ; Yeongjin Han ; Jaehun Park ; In Soo Ko pp.1981-1984

Conceptual design of a 50-MHz, 300-keV/u CW heavy ion RFQ Yong-Sub Cho ; Ji-Ho Jang ; Han-Sung Kim pp.1985-1988

Development of a prototype niobium SRF cavity for the PEFP proton superconducting linac Han-Sung Kim ; Hyeok-Jung Kwon ; Yong-Sub Cho ; Sun An pp.1989-1993

Phase stability in the RF reference system for the PEFP 100-MeV LLRF control system Kyung-Tae Seol ; Hyeok-Jung Kwon ; Hyeon-Ju Choi ; Yong-Sub Cho pp.1994-1997

Beam emittance measurement and simulation of the PEFP front end accelerator Hyeok-Jung Kwon ; Han-Sung Kim ; Dae-Il Kim ; Ji-Ho Jang ; Yong-Sub Cho pp.1998-2001

Investigation of the radionuclide inventory and the production yields of the target stacks at the PEFP radioisotope production facility Sang-Pil Yoon ; In-Seok Hong ; Yong-Sub Cho pp.2002-2007

Beam collimation in the PEFP RCS Ji-ho Jang ; Hyeok Jung Kwon ; Yong Sub Cho ; Yong Yung Lee pp.2008-2012

Effect of a magnetic field induced by using a solenoid on a compact microwave proton source I. S. Hong ; B. S. Park ; Y. S. Cho pp.2013-2015

Electromagnetic and thermal analysis of the vacuum chamber for a switching magnet Bum-Sik Park ; Han-Sung Kim ; Yong-Sub Cho pp.2016-2019

Preliminary study on the vacuum protection valve of the PEFP beamline H. R. Lee ; B. S. Park ; H. S. Kim ; H. J. Kwon ; Y. S. Cho pp.2020-2023

Analysis of the beam instability of the PLS-Ⅱ storage ring due to superconducting RF cavities Sun An ; Young-Do Joo ; Heung-Sik Kang pp.2024-2028

Characteristics of a discharge-plasma waveguide for high-energy accelerators and X-ray light source applications Seong Yong Oh ; Min-Seok Kim ; In Hyuk Nam ; Hyyong Suk pp.2029-2031

Design and performance test of a thermal tuning system for the PEFPDTL Kyung Ryul Kim ; Jun Park ; Hyung Gyun Kim ; Hee Seob Kim ; Chong Chul Yoon ; Yoon Gyu Son ; Hyeok Jung Kwon ; Han Sung Kim ; Yong Sub Cho pp.2032-2040

Enhancing the 1-butanol tolerance in Escherichia coli through repetitive proton beam irradiation Haeyoung Jeong ; Jihee Han pp.2041-2045

Modulation of the sound press level by the treatment of polymer diaphragms through ion implantation method Sunmog Yeo ; Jae-Won Park ; Ho-Jae Lee pp.2046-2049

Structural and optical properties of hydrogen-ion-implanted ZnO nanorods Y.-B. Lee ; C.-H. Kwak ; S.-Y. Seo ; S.-H. Kim ; C.-I. Park ; B.-H. Kim ; S.-H. Park ; Yong-Dae Choi ; S.-W. Han pp.2050-2054

3D X-ray tomography system in the PLS 7B2 bio-imaging beamline Hyo-Jin Choi ; Hyo-Yun Kim ; Jae-Hong Lim ; Jung Yun Huang pp.2055-2058

Determination of the distal dose edge in a human phantom by measuring the prompt gamma distribution : a Monte Carlo study Chul Hee Min ; Han Rim Lee ; Yeon Su Yeom ; Sungkoo Cho ; Chan Hyeong Kim pp.2059-2062

Characterization of SiC nanostructures in crystalline and porous silicon formed by ion beam synthesis Hyung-Joo Woo ; Gi-Dong Kim ; Han-Woo Choi ; Joon-Kon Kim pp.2063-2067

Changes of cancer chemopreventive enzyme activities in human breast cancer cells irradiated with proton beams Kyu-Shik Lee ; Jin-Young Mo ; Kyung-Soo Nam ; Yun-Hee Shon pp.2068-2071

Synthesis of Au-Ag composite nanorods via proton beam irradiation Yeong-Joon Kim ; Jae Hee Song pp.2072-2076

High-resolution and high-contrast bio-medical X-ray imaging by using synchrotron radiation in the PLS J. Y. Huang ; K. S. Jin ; J. H. Lim ; H. Y. Kim ; S. D. Jang ; H. J. Choi ; K. H. Gil ; S. K. Lee pp.2077-2082

Effects of a phosphorus precursor on structure and activity of Ni₂P/SiO₂ hydrotreating catalysts : EXAFS studies Hye-Ryun Seo ; Kye-Sung Cho ; Sung-Ho Kim ; Yong-Kul Lee pp.2083-2087

Investigation of nanomorphology change in bulk heterojunction films using synchrotron X-ray diffraction Minjung Shin ; Hwajeong Kim ; Youngkyoo Kim ; Kyuyoung Heo ; Moonhor Ree pp.2088-2092

Activation of 45-MeV proton irradiation and proton-induced neutron irradiation in polymers Se-Jin Ra ; Kye-Ryung Kim ; Myung-hwan Jung ; Tae-Keon Yang pp.2093-2099

Influence of pressing on the nanostructure and electrical properties of semiconducting polymer nanolayers Jiho Park ; Hwajeong Kim ; Youngkyoo Kim pp.2100-2103

Development of an external Faraday cup for beam current measurements Kye-Ryung Kim ; Myung-Hwan Jung ; Se Jin Ra ; Seok Ki Lee ; Sun Taek Hwang pp.2104-2107

Radiation damage in a proton-irradiated ZnO single crystal Eunmo Lee ; Sucheol Lee ; W. Lee ; Cheol Eui Lee pp.2108-2111

Development of a proton energy monitoring device for a high count rate environment H. O. Kim ; H. J. Kim ; J. H. So ; Y. S. Hwang ; S. Y. Kim ; Sang Jun Kang ; Kyeryung Kim pp.2112-2117

Two-dimensional beam profile monitoring by using a LYSO crystal Sang Jun Kang ; H. J. Kim ; Y. S. Hwang ; J. H. So ; Kyeryung Kim ; S. K. Lee ; Sejin Ra ; Sunghwan Kim pp.2118-2121

Development of a gas scintillation detector for high-intensity proton-beam monitoring J. H. So ; H. J. Kim ; Young Seok Hwang ; Sang Jun Kang ; Kyeryung Kim pp.2122-2125

Height-controlled InGaN Quantum Dots and Light-emitting Diode Applications 박일규, 박성주 pp.1828-1832

Analysis of Earth Tide as a Whole-Earth Forced Oscillation and Its Computation 나성호, 문우일 pp.1866-1872

PLD Growth of Epitaxially-stabilized 5d Perovskite SrIrO3 Thin Films 장승엽, 정진석, 문순재, 전병철 pp.1814-1817

Fabrication and Performance of ACTFEL Display Devices Using Manganese-doped Zinc Germanate as a Green-emitting Electroluminescent Layer 김주한, 윤경호 pp.1861-1865

Fabrication and Characterization of a Polycrystalline 3C-SiC Piezoresistive Micro-pressure Sensor 정귀상 pp.1759-1762

Scattering Matrix Formulation of the Total Photoionization of Two-electron Atoms 이민호, 최낙렬 pp.1799-1806

Characteristics of Volatility in Data Network Traffic 이창용 pp.1880-1883

Energy and Fluence Measurements for Fast Neutrons from the 2D(d,n)3He Reaction 김기동, H. J. Woo, J. K. Kim, Y. O. Lee, H. W. Choi pp.1772-1776

Mg Vacancy Defect Induced Half Metallic MgO(001) Film 김동유, 홍지상, 양정화 pp.1729-1732

Two-way Quantum Direct Communication Protocol Using Entanglement Swapping 홍창호, 임종인, 김지인, 양형진 pp.1733-1737

Dynamical Behaviors in Earthquake Structures 정성아, 하덕호, 김수용, 정종훈, 이동인, 정재원, 장기호, 김경식 pp.1877-1879

Quantum Cutting in SrAl12O19:Pr3+ Nanodisks under Vacuum-UV Excitation Zhao-Gang Nie, Takayoshi Kobayashi, 임기수 pp.1847-1851

Effects of 2-MeV Electron Beam Irradiation on the Physical Properties of Polyvinylalcohol-CdS and Polyvinylalcohol-CdS-2 Mercaptoethanol Nanoparticles 유동선, 이정두, 김일곤, 이병철, 한영환, 하성용 pp.1807-1813

Analysis of Propagating Beam Transverse-mode Evolution by Using the Wigner Distribution Function 이창혁, 박상준, Hyesuk Lee, 노재우 pp.1781-1786

Effects of Growth Interruption of ZnO Buffer Layers on the Structural and the Optical Properties of ZnO Thin Films Grown by Using PA-MBE 조민영, 김민수, 김도엽, 이동율, 김진수, 김종수, 이주인, 임재영, 최현영, 임광국, 전수민, 김군식 pp.1833-1837

Gluonic Flux Tube Profiles in Mesons 김은주, 최종범, Moon Q. Whang pp.1787-1798

Surgical Clips for Observation of Respiratory Motion of the Breast Via 2D Fluoroscopy and 3D CT Scans 이레나, 서현석 pp.1852-1860

Role of the Self-field in Superradiant Cavity Radiation of Intense Periodic Electron Bunches W. H. Lee, 서윤호 pp.1888-1891

Reduction of Line Width and Edge Roughness by Using a Resist Reflow Process for Extreme Ultraviolet Lithography In Wook Cho, Hyunsu Kim, Joo-Yoo Hong, Hye-Keun Oh, Seong Wook Kim pp.1767-1771

Magnetic Properties of a Mixed Spin-3/2 and Spin-2 Ising Ferrimagnetic System within the Effective-field Theory Bayram Deviren, Ersin Kantar, Mustafa Keskin pp.1738-1747

Combinatorial Synthesis of In-Ga-Sn-O Channel Transparent Thin-film Transistors 문준철, 윤준석, 주홍렬, 박창우 pp.1843-1846

Effect of Substrate Temperature on the Physical Properties of Ni49.7Ti50.3 Thin Film Microactuator Emad Kh. Al-Shakarchi, Matti N. Makadsi, Kadhum A. Essa pp.1822-1827

Monte Carlo Simulation Study on Dose Enhancement by Gold Nanoparticles in Brachytherapy 조성구, 정종휘, 윤명근, 김찬형 pp.1754-1758

Pair Production of Majorana Neutrinos by Annihilation of Charged Particles in High Energy Collision Y. Goh, H. K. Lee, W-G. Paeng, Y. Yoon pp.1884-1887

Applications of the Surface Plasmon Polariton in the Au Nanocircuit Zheyu Fang, Linran Fan, Shan Huang, Xing Zhu pp.1725-1728

Crystallographic and Magnetic Properties of Vanadium-substituted Li-Co-Ti Ferrite 권우현, 이재광, 이승화, 채광표 pp.1838-1842

Development of Scintillation-fiber Sensors for Measurements of Thermal Neutrons in Mixed Neutron-gamma Fields 장경원, 유욱재, 박장연, 이봉수 pp.1777-1780

Characteristics of Polycrystalline 3C-SiC Microresonators for Various Nitrogen Doping Concentrations 정귀상, 한기봉 pp.1818-1821

A Novel Optical Delay Line Using a Rotating Planar Reflector for Fast Measurement of a Terahertz Pulse 김근주, 전석기, 한성태 pp.1763-1766

Determination of the Spatial Resolution of an Aperture-type Near-field Scanning Optical Microscope Using a Standard Sample of a Quantum-dot-embedded Polymer Film 김정용, D. C. Kim, K. Nakajima, H. Aoki, T. Mitsui pp.1748-1753

Some Static Spherically Symmetric Solutions in Horava-Lifshitz Gravity and Galactic Rotation Curves 이태훈 pp.1873-1876

참고문헌 (12건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 B. Hahn-Hagerdal, M. Galbe, M. F. Gorwa-Grauslund, G. Liden and G. Zacchi, Trends Biotechnol. 24, 549 (2006). 미소장
2 J. L. Fortman, S. Chhabra, A. Mukhopadhyay, H. Chou, T. S. Lee, E. Steen and J. D. Keasling, Trends Biotechnol. 26, 375 (2008). 미소장
3 P. Durre, Biotechnol J. 2, 1525 (2007). 미소장
4 D. T. Jones and D. R. Woods, Microbiol. Rev. 50, 484 (1986). 미소장
5 S. Atsumi et al., Metab. Eng. 10, 305 (2008). 미소장
6 S. Atsumi, T. Hanai and J. C. Liao, Nature. 451, 86 (2008). 미소장
7 Y. N. Sardessai and S. Bhosle, Curr. Sci. 82, 622 (2002). 미소장
8 E. P. Knoshaug and M. Zhang, Appl. Biochem. Biotechnol. 153, 13 (2009). 미소장
9 A. Buckling, R. Craig Maclean, M. A. Brockhurst and N. Colegrave, Nature. 457, 824 (2009). 미소장
10 J. E. Barrick et al., Nature. 461, 1243 (2009). 미소장
11 B. Tippin, P. Pham and M. F. Goodman, Trends Microbiol. 12, 288 (2004). 미소장
12 C. D. Herring et al., Nat. Genet. 38, 1406 (2006). 미소장

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