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Background/Aims: In patients with coronary artery stents, the cost of clopidogrel has been cited as a factor in

the premature discontinuation of therapy. Thus, the introduction of lower-cost generic clopidogrel may increase

patient compliance. However, platelet inhibition by generic clopidogrel has not been compared to the original

clopidogrel formulation in patients with coronary artery stents.

Methods: We prospectively enrolled 20 patients receiving chronic therapy with the original clopidogrel bisulfate

(Plavix®). After assessing patient compliance with Plavix®, maintenance therapy was switched to generic

clopidogrel bisulfate (Plavitor®). Platelet reactivity was assessed at baseline and 30-day after the switch using

conventional aggregometry and the VerifyNow P2Y12 assay.

Results: All patients completed maintenance therapy with Plavitor®. Before and after switching therapy maximal

(36.5 ± 7.9% vs. 39.8 ± 16.2%, p = 0.280) and late platelet aggregation (23.5 ± 10.9% vs. 29.1 ± 18.3%, p =

0.156) with 5 μmol/L adenosine diphosphate (ADP) stimulus did not differ. Likewise, 20 μmol/L ADP-induced

platelet aggregation and P2Y12 reaction unit in patients on Plavitor® therapy was comparable to that in patients

on Plavix® therapy. However, Bland-Altman analysis showed wide limits of agreement between measured

platelet reactivity on Plavix® vs. Plavitor® therapies.

Conclusions: Among patients on Plavix® maintenance therapy with coronary stents, replacement with Plavitor®

shows a comparable inhibition of ADP-induced platelet aggregation. However, due to poor inter-therapy

agreement, between two regimens, physicians may be cautious when introducing generic clopidogrel bisulfate.

(Korean J Intern Med 2010;25:154-161)

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Molecular mechanism of insulin resistance in obesity and type 2 diabetes Kangduk Choi ;Young-Bum Kim pp.119-129

Diet and airway obstruction :a cross sectional study from the second Korean National Health and Nutrition Examination Survey Jin Hwa Lee ;Yun Su Sim ;Gee Young Suh ;Jeong-Seon Ryu ;Dong Ho Shin ;Kyung Haeng Koh ;Yeon Jae Kim pp.132-139

Clinical characteristics of colonic diverticulosis in Korea :a prospective study Jung Hoon Song ;You Sun Kim ;Jin Ho Lee ;Kyung Sun Ok ;Soo Hyung Ryu ;Jung Hwan Lee ;Jeong Seop Moon pp.140-146

Characteristics of double-chambered right ventricle in adult patients Yu Jeong Choi ;Seung Woo Park pp.147-153

(The)Impact of generic clopidogrel bisulfate on platelet inhibition in patients with coronary artery stents :results of the ACCEL-GENERIC study Young-Hoon Jeong ;Jin-Sin Koh ;Min-Kyung Kang ;Yeon-Jeong Ahn ;In-Suk Kim ;Yongwhi Park ;Seok-Jae Hw pp.154-161

(The)Body mass index as a prognostic factor of critical care So Yeon Lim ;So I Kim ;Yon Ju Ryu ;Jin Hwa Lee ;Eun Mi Chun ;Jung Hyun Chang pp.162-167

(The)Contribution of abdominal obesity and dyslipidemia to metabolic syndrome in psychiatric patients Sung-Hwan Kim ;Kiwon Kim ;Mi Hyang Kwak ;Hak Jin Kim ;Hong-Sup Kim ;Ki Hoon Han pp.168-173

Variable association between components of the metabolic syndrome and electrocardiographic abnormalities in Korean adults Hong-Kyu Kim ;Chul-Hee Kim ;Kwan-Ho Ko ;Seong-Wook Park ;Joong-Yeol Park ;Ki-Up Lee pp.174-180

(The)Risk factors and outcome of acute kidney injury in the intensive care units Woo Young Park ;Eun Ah Hwang ;Mi Hyung Jang ;Sung Bae Park ;Hyun Chul Kim pp.181-187

Comparison of patients starting hemodialysis with those underwent hemodialysis 15 years ago at the same dialysis center in Korea Su Jin Seok ;Jung Hoon Kim ;Hyo Wook Gil ;Jong Oh Yang ;Eun Young Lee ;Sae Yong Hong pp.188-194

Serum prohepcidin levels in Helicobacter pylori infected patients with iron deficiency anemia Sun-Young Lee ;Eun Young Song ;Yeo Min Yun ;So Young Yoon ;Yo Han Cho ;Sung-Yong Kim ;Mark Hong Lee pp.195-200

Correlation of anti-cyclic citrullinated antibody with hand joint erosion score in rheumatoid arthritis patients Hyun Hee Kim ;JiHun Kim ;Sung-Hoon Park ;Seong-Kyu Kim ;Ok-Dong Kim ;Jung-Yoon Choe pp.201-206

(The)Current practice of skin testing for antibiotics in Korean hospitals So Hee Lee ;Heung Woo Park ;Sae Hoon Kim ;Yoon Seok Chang ;Sun Sin Kim ;Sang Heon Cho ;Kyung Up Min pp.207-212

Two lung masses with different responses to pemetrexed Kwang Young Park ;Jae Wook Jung ;Seung Bum Nam ;Ho Jin Lee ;Hyo Seok Kim ;Yoon Hee Choi ;Jae Cheol L pp.213-216

(A)Case of diabetic neuropathy combined with Guillain-Barre syndrome Heung-Yong Jin ;Kyung-Ae Lee ;So-Young Kim ;Ji-Hyun Park ;Hong-Sun Baek ;Tae-Sun Park pp.217-220

(A)Large intrathoracic meningocele in a patient with neurofibromatosis-1 Jae Wook Jeong ;Kwang Young Park ;Sang Min Yoon ;Du Whan Choe ;Cheol Hyeon Kim ;Jae Cheol Lee pp.221-223

Inflammatory polyarthritis in a patient with psoriasis :is it psoriatic arthritis or rheumatoid arthrirtis? Kwang-Hoon Lee ;Myoung-Kyun Son ;You-Jung Ha ;Sang-Tae Choi ;Sang-Won Lee ;Yong-Beom Park ;Soo-Kon L pp.224-226

Smoking Rather than Diet Deficiency is Related with Airway Obstruction in Korea 김호중 pp.130-131

참고문헌 (34건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study 네이버 미소장
2 Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation 네이버 미소장
3 Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. 네이버 미소장
4 Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. 네이버 미소장
5 Addition of clopidogrel to aspirin in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial 네이버 미소장
6 Paclitaxel-eluting versus uncoated stents in primary percutaneous coronary intervention. 네이버 미소장
7 Stents versus coronary-artery bypass grafting for left main coronary artery disease. 네이버 미소장
8 Long-Term Mortality After Percutaneous Coronary Intervention With Drug-Eluting Stent Implantation Versus Coronary Artery Bypass Surgery for the Treatment of Multivessel Coronary Artery Disease 네이버 미소장
9 Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. 네이버 미소장
10 Kotani J, Nanto S, Morozumi T, et al. Angioscopic findings of the neo-intimal coverage over the sirolimus-eluting stent: nine months follow-up study. J Am Coll Cardiol 2006;47(Suppl B): 27B. 미소장
11 Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project. 네이버 미소장
12 Differential Effects of Drug-Eluting Stents on Local Endothelium-Dependent Coronary Vasomotion 네이버 미소장
13 Late clinical events after clopidogrel discontinuation may limit the benefit of drug-eluting stents: an observational study of drug-eluting versus bare-metal stents. 네이버 미소장
14 Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study. 네이버 미소장
15 Incomplete Stent Apposition and Very Late Stent Thrombosis After Drug-Eluting Stent Implantation 네이버 미소장
16 Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. 네이버 미소장
17 Frequency of and Risk Factors for Stent Thrombosis After Drug-Eluting Stent Implantation During Long-Term Follow-Up 네이버 미소장
18 Prevalence, Predictors, and Outcomes of Premature Discontinuation of Thienopyridine Therapy After Drug-Eluting Stent Placement: Results From the PREMIER Registry 네이버 미소장
19 Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation. 네이버 미소장
20 Prevention of Premature Discontinuation of Dual Antiplatelet Therapy in Patients With Coronary Artery Stents: A Science Advisory From the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, With Representation From the American College of Physicians 네이버 미소장
21 Wood S. HeartWire: Mixed thoughts on how generic clopidogrel might impact patients, providers [Internet]. Montreal: theheart.org, 2006 [cited 2010 Mar 15]. Available from: http://www. theheart.org /article/729929.do. 미소장
22 Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. 네이버 미소장
23 Impact of Platelet Reactivity After Clopidogrel Administration on Drug-Eluting Stent Thrombosis 네이버 미소장
24 High post‐treatment platelet reactivity identified low‐responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome 네이버 미소장
25 Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets: Results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) Study 네이버 미소장
26 Randomized Comparison of Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients With High Post-Treatment Platelet Reactivity: Results of the ACCEL-RESISTANCE (Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients With Clopidogrel Resistance) Randomized Study 네이버 미소장
27 The optimal threshold of high post-treatment platelet reactivity could be defined by a point-of-care VerifyNow P2Y12 assay 네이버 미소장
28 Variability in platelet responsiveness to clopidogrel among 544 individuals. 네이버 미소장
29 Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation 네이버 미소장
30 Patti G, Nusca A, Mangiacapra F, Gatto L, D’Ambrosio A, Di Sciascio G. Point-of-care measurement of clopidogrel responsiveness predicts clinical outcome in patients undergoing percutaneous coronary intervention results of the Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Platelet Reactivity Predicts Outcome (ARMYDA-PRO) study. J Am Coll Cardiol 2008;52:1128-1133. 미소장
31 Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-up. 네이버 미소장
32 Platelet Function Monitoring in Patients With Coronary Artery Disease 네이버 미소장
33 Bliden KP, DiChiara J, Tantry US, Bassi AK, Chaganti SK, Gurbel PA. Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate? J Am Coll Cardiol 2007;49:657-666. 미소장
34 Antiplatelet Therapy and Stent Thrombosis After Sirolimus-Eluting Stent Implantation 네이버 미소장

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