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초록보기

LHX8 (LIM homeobox 8) is a germ cell?specific transcription

factor that is crucial for folliculogenesis in the ovary and represents

a candidate gene for premature ovarian insufficiency. We

analyzed whether mutations in the LHX8 gene in 96 Korean

women with premature ovarian insufficiency. The sequence

analysis identified four known SNPs included one synonymous

and three intronic variants and discovered three novel singlenucleotide

polymorphisms in intron 4 (c.114+99C>A), intron

4 (c.114+100C>A) and intron 6 (c.390+77C>G) of the LHX8

gene. These polymorphisms were also found in controls at frequencies

that were not statistically significant. Functional mutations

in LHX8 gene are rare in Korean women with premature

ovarian insufficiency.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Novel single-nucleotide polymorphisms of LHX8 gene in Korean women with premature ovarian insufficiency Sanghyun Jeon ;Hyung Jae Won ;You Shin Kim ;Sang Woo Lyu ;Hyun Ha Seok ;Nam Keun Kim ;Woo Sik Lee ;S pp.397-400

Development of 10 microsatellite loci from the Korean ratsnake (Elaphe schrenckii) and its application across Elaphe species from South Korea, Russia, and China Junghwa An ;Mun-Jeong Kim ;Daesik Park ;Junghyun Lee ;Victor Krukov ;Kyung-Seok Kim ;Hang Lee ;Mi-So pp.401-405

Tandem B1 SINE retro-elements may provide a basis for natural antisense transcription in the magi1 locus of the mouse (Mus musculus) Inge Seim ;Adrian C. Herington ;Lisa K. Chopin pp.407-411

New polymorphic microsatellite markers in pacific abalone Haliotis discus hannai and their application to genetic characterization of wild and aquaculture populations Hye Suck An ;Jeong-Ho Lee ;Chun Mae Dong ;Jae Koo Noh ;Hyun Chul Kim ;Chul Ji Park ;Kyong Dae Park ; pp.413-418

Genetic diversity and marker-trait associations in a collection of Pak-choi (Brassica rapa L. ssp. chinensis Makino) accessions Shuancang Yu ;Fenglan Zhang ;Xiaoyi Wang ;Xiuyun Zhao ;Deshuang Zhang ;Yangjun Yu ;Jiabing Xu pp.419-428

Overexpression of the MUC2 gene through promoter hypomethylation in mucinous cell carcinomas and signet ring cell carcinomas of gastric cancer Han Ik Bae ;Ying-Hua Li ;Yeon Kyeong Na ;Young Won Jung ;Su Man Lee ;Jae Sub Yang ;Dong Sun Kim pp.429-435

Molecular identification of Ammodytes (PISCES, ammodytidae) larvae, with ontogenetic evidence on separating populations Jin Koo Kim ;William Watson ;John Hyde ;Nancy Lo ;Jin Young Kim ;Sung Kim ;Young Seop Kim pp.437-445

Molecular characterization of anionic defensin-like peptide in immune response of silkworm, Bombyx mori L. (Lepidoptera) Ki-Joon Song ;Bo-Ryung Park ;So Youn Kim ;Kwang Sook Park pp.447-453

Mitochondrial transcription factor B1 is required for mitochondrial function and oxidative stress resistance in Drosophila Hyunjin Kim ;Min Ju Kim ;Ji Eun Jeong ;Jongkyeong Chung ;Hye-Jeong Lee ;Hyongjong Koh pp.455-461

Development of peptide nucleic acid (PNA) microarray for identification of Panax species based on the nuclear ribosomal internal transcribed spacer (ITS) and 5.8S rDNA regions Jei-Wan Lee ;Kyong-Hwan Bang ;Jae-Jin Choi ;Jong-Wook Chung ;Jeong-Hoon Lee ;Ick-Hyun Jo ;A-Yeon Seo pp.463-468

Combination of polymorphisms between MTHFR and TS gene modulates survival after 5-fluorouracil-based therapy in colorectal cancer patients Jong Woo Kim ;Jae Ho Lee ;Seung Ho Hong ;Dong Jin Yim ;Hee Jung An ;So Young Chong ;Doyeun Oh ;Nam K pp.469-475

Sequence variation in ITS spacers and 5.8S rDNA and relationship of E, St, P, Ns, Xm, and H genomes in the genera of Agropyron, Elytrigia, Leymus, Pascopyrum, Psathyrostachys, and Hordeum Tae-Won Kim ;Joon-Chul Kim ;George Fedak ;Jae-Han Son ;Kyong-Cheul Park ;Nam-Soo Kim pp.477-485

Characterization and expression pattern of IbPRP1 and IbPRP2 stress-related genes from sweetpotato Sang-Gyu Seo ;Seo Bum Jeon ;Ji-Seoung Kim ;Ji-Min Shin ;Jong-Bo Kim ;Seung-Won Kang ;Gung-Pyo Lee ;S pp.487-497

참고문헌 (17건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Choi Y, Ballow DJ, Xin Y and Rajkovic A (2008a) Lim homeobox gene, lhx8, is essential for mouse oocyte differentiation and survival. Biol. Reprod. 79: 442-449. 미소장
2 Choi Y, Yuan D and Rajkovic A (2008b) Germ cell-specific transcriptional regulator sohlh2 is essential for early mouse folliculogenesis and oocyte-specific gene expression. Biol. Reprod. 79: 1176-1182. 미소장
3 Conway GS (2000) Premature ovarian failure. Br. Med. Bull. 56: 643-649. 미소장
4 Endocrine disruption for endocrinologists (and others). 네이버 미소장
5 A novel 30 bp deletion in the FOXL2 gene in a phenotypically normal woman with primary amenorrhoea: Case report 네이버 미소장
6 Goswami D and Conway GS (2005) Premature ovarian failure. Hum. Reprod. Update 11: 391-410. 미소장
7 Harris SE, Chand AL, Winship IM, Gersak K, Aittomaki K and Shelling AN (2002) Identification of novel mutations in FOXL2 associated with premature ovarian failure. Mol. Hum. Reprod. 8: 729-733. 미소장
8 Harris SE, Chand AL, Winship IM, Gersak K, Nishi Y, Yanase T, Nawata H and Shelling AN (2005) INHA promoter polymorphisms are associated with premature ovarian failure. Mol. Hum. Reprod. 11: 779-784. 미소장
9 Kovanci E, Rohozinski J, Simpson JL, Heard MJ, Bishop CE, and Carson SA (2007) Growth differentiating factor-9 mutations may be associated with premature ovarian failure. Fertil. Steril. 87: 143-146. 미소장
10 Lacombe A, Lee H, Zahed L, Choucair M, Muller JM, Nelson SF, Salameh W and Vilain E (2006) Disruption of POF1B binding to nonmuscle actin filaments is associated with premature ovarian failure. Am. J. Hum. Genet. 79: 113-119. 미소장
11 Qin Y, Choi Y, Zhao H, Simpson JL, Chen ZJ and Rajkovic A (2007) NOBOX homeobox mutation causes premature ovarian failure. Am. J. Hum. Genet. 81: 576-581. 미소장
12 Qin Y, Zhao H, Kovanci E, Simpson JL, Chen ZJ and Rajkovic A (2008) Analysis of LHX8 mutation in premature ovarian failure. Fertil. Steril. 89: 1012-1014. 미소장
13 Rajkovic A, Pangas SA, Ballow D, Suzumori N and Matzuk MM (2004) NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science 305: 1157-1159. 미소장
14 Rossetti R, Di Pasquale E, Marozzi A, Bione S, Toniolo D, Grammatico P, Nelson LM, Beck-Peccoz P and Persani L (2009) BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein. Hum. Mutat. 30: 804-810. 미소장
15 Simpson JL and Rajkovic A (1999) Ovarian differentiation and gonadal failure. Am. J. Med. Genet. 89: 186-200. 미소장
16 Watkins WJ, Umbers AJ, Woad KJ, Harris SE, Winship IM, Gersak K and Shelling AN (2006) Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure. Fertil. Steril. 86: 1518-1521. 미소장
17 Zhao H, Chen ZJ, Qin Y, Shi Y, Wang S, Choi Y, Simpson JL and Rajkovic A (2008) Transcription factor FIGLA is mutated in patients with premature ovarian failure. Am. J. Hum. Genet. 82: 1342-1348. 미소장

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