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DEPs (diesel exhaust particles) like any other particles can be also inhaled into lung to participate in a damaging

reaction to the organ. Possible damages might be apoptosis and inflammatory responses to the cells in

respiratory track. The aim of this study was cytotoxicity evaluation of DEPs from five in-use diesel vehicles

using a murine macrophage cell (RAW 254.7). We found that most DEPs have a considerable cytotoxicity compared

to the control and SRM 2975. When measured by MTT assay and extents of apoptosis, DEPs of two highmileage

vehicles had higher toxicity than those of the other three low-mileage vehicles tested. Although mRNA

expression level of TNF-α somewhat explains the trend of cytotoxicity and apoptosis, that of IL-1β did not.

Correlation studies among the extents of MTT assay, apoptosis, and TNF-α expression showed that the extents

between apoptosis and TNF-α expression was most highly correlated (r=0.96). These results suggest that cytotoxicity

of various DEPs could be compared easily by measuring the extent of apoptosis or TNF-α expression

by DEPs.

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기사명 저자명 페이지 원문 목차
Monitoring of the distribution of ambient air particles in Seoul using a cascade impactor and the particle toxicity Eun-Jung Park ; Dae-Seon Kim ; Kwangsik Park pp.99-109

국내 디젤 차량 배기 입자가 쥐 대식세포에 미치는 세포독성 평가 이장한 ; 이용권 ; 이지영 ; 이승복 ; 김선화 ; 배귀남 ; 이학성 ; 임철수 ; 정남현 pp.111-120

생쥐에서 황사로 인한 항원관련 천식성 기도 염증과 기도 과민성에 미치는 영향 임흥빈 ; 김승형 pp.121-129

Methyl formate의 랫드를 이용한 급성 및 아만성 흡입독성 평가 김현영 ; 이성배 ; 한정희 ; 강민구 ; 양정선 pp.131-143

유수식 연속노출장비를 이용한 과불화화합물(PFOS, PFOA)이 송사리(Oryzias latipes) 알의 초기발생과정에 미치는 영향 연구 조재구 ; 김경태 ; 류태권 ; 박유리 ; 윤준헌 ; 이철우 ; 김현미 ; 최경희 ; 정기은 pp.145-151

Daphnia magna를 이용한 과불화화합물의 독성평가 김경태 ; 조재구 ; 윤준헌 ; 이철우 ; 최경희 ; 김현미 ; 류지성 pp.153-159

원유의 WSF(water soluble fraction)가 참굴의 초기생활사에 미치는 영향 신윤경 ; 김응오 ; 조기채 ; 전제천 ; 진영국 pp.161-168

지역단위 생태위해성평가 선진국사례 분석 신유진 ; 이우미 ; 안윤주 pp.169-177

참고문헌 (30건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Activation of IL-1β, IGF-1 and IGF-2 in Injured Rat Skeletal Muscle by Low Power He-Ne IR Laser and Electrical Stimulation 소장
2 김 헌. 분자생물학적 기법을 활용한 대기오염 관련 연구. 대한산업의학회 제28차 춘계학술대회 2002; 11-22. 미소장
3 COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo 네이버 미소장
4 Mutagenicity of diesel exhaust particles mediated by cell–particle interaction in mammalian cells 네이버 미소장
5 Boland S, Baeza-Squiban A, Bonvallot V, Houcine O, Pain C, Meyer M and Marano F. Similar cellular effects induced by diesel exhaust particles from a representative diesel vehicle recovered from filters and Standard Reference Material 1650, Toxicol In Vitro 2001; 15(4-5): 379-385. 미소장
6 Similarities and differences in PM 10 chemical source profiles for geological dust from the San Joaquin Valley, California 네이버 미소장
7 The role of diesel exhaust particles and their associated polyaromatic hydrocarbons in the induction of allergic airway disease 네이버 미소장
8 Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure 네이버 미소장
9 Inflammatory and genotoxic effects of diesel particles in vitro and in vivo. 네이버 미소장
10 Particulate matter induces cytokine expression in human bronchial epithelial cells. 네이버 미소장
11 Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. 네이버 미소장
12 Keogh DU, Ferreira L and Morawska L. Development of a particle number and particle mass vehicle emissions inventory for an urban fleet, Environ Modelling & Software 2009; 24(11): 1323-1331. 미소장
13 Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. 네이버 미소장
14 Airway inflammatory responses to oxidative stress induced by prolonged low-dose diesel exhaust particle exposure from birth differ between mouse BALB/c and C57BL/6 strains. 네이버 미소장
15 Diesel exhaust particle-induced cell death of cultured normal human bronchial epithelial cells. 네이버 미소장
16 Application of genetic algorithm for optimization of control strategy in parallel hybrid electric vehicles 네이버 미소장
17 Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays 네이버 미소장
18 Primary and secondary carbonaceous species in the atmosphere of Western Riverside County, California 네이버 미소장
19 Diesel exhaust particles increase IL-1β-induced human β-defensin expression via NF-κB-mediated pathway in human lung epithelial cells 네이버 미소장
20 Nitta H, Sato T, Nakai S, Maeda K, Aoki S and Ono M. Respiratory health associated with exposure to automobile exhaust. I. Results of cross-sectional studies in 1979, 1982, and 1983, Arch Environ Health 1993; 48(1): 53-58. 미소장
21 The role of iron in reactive oxygen species generation from diesel exhaust particles 네이버 미소장
22 Health risk assessment of urban suspended particulate matter with special reference to polycyclic aromatic hydrocarbons: a review. 네이버 미소장
23 Long-term inhalation of diesel exhaust affects cytokine expression in murine lung tissues: comparison between low- and high-dose diesel exhaust exposure. 네이버 미소장
24 Particulate air pollution and acute health effects 네이버 미소장
25 Particle-bound PAH content in ambient air 네이버 미소장
26 Indoor Air Pollution: A Public Health Perspective 네이버 미소장
27 Quinoid redox cycling as a mechanism for sustained free radical generation by inhaled airborne particulate matter 네이버 미소장
28 Diesel exhaust particles induced release of interleukin 6 and 8 by (primed) human bronchial epithelial cells (BEAS 2B) in vitro. 네이버 미소장
29 Vinitketkumnuen U, Kalayanamitra K, Chewonarin T and R Kamens. Particulate matter, PM10 & PM2.5 levels, and airborne mutagenicity in Chiang Mai, Thailand, Mutat Res 2002; 519(1-2): 121-131. 미소장
30 Effects of diesel exhaust particles on the release of interleukin-1 and tumor necrosis factor-alpha from rat alveolar macrophages. 네이버 미소장

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