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Morphinans are a class of compounds containing the basic structure of morphine. It is wellknown that morphinans possess diverse pharmacological effects on the central nervous system. This review will demonstrate novel neuroprotective effects of several morphinans such as, dextromethorphan, its analogs and naloxone on the models of multiple neurodegenerative disease by modulating glial activation associated with the production of a host of proinflammatory and neurotoxic factors, although dextromethorphan possesses neuropsycotoxic potentials. The neuroprotective effects and the therapeutic potential for the treatment of excitotoxic and inflammatory neurodegenerative diseases, and underlying mechanism of morphinans are

discussed.

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Epigenetic control of stem cell fate to neurons and glia Hyun-Jung Kim ;Michael G. Rosenfeld pp.1467-1473

Effects of brain insults and pharmacological manipulations on the adult hippocampal neurogenesis Kyung-Ok Cho ;Seong Yun Kim pp.1475-1488

Heterogeneity in primary nociceptive neurons :from molecules to pathology Eduardo Gascon ;Aziz Moqrich pp.1489-1507

Endogenous lipid-derived ligands for sensory TRP ion channels and their pain modulation Sangsu Bang ;Sungjae Yoo ;Uhtaek Oh ;Sun Wook Hwang pp.1509-1520

Current perspectives on the selective regulation of dopamine D₂and D₃receptors Dong Im Cho ;Mei Zheng ;Kyeong-Man Kim pp.1521-1538

Inflammation and Alzheimer's disease Young-Jung Lee ;Sang Bae Han ;Sang-Yoon Nam ;Ki-Wan Oh ;Jin Tae Hong pp.1539-1556

How to overcome retinal neuropathy :the fight against angiogenesis-related blindness Dong Hyun Jo ;Jin Hyoung Kim ;Jeong Hun Kim pp.1557-1565

Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis Chang Wook Lee ;Ji Woong Choi ;Jerold Chun pp.1567-1574

Neuropsychopharmacological understanding for therapeutic application of morphinans Eun-Joo Shin ;Jau-Shyong Hong ;Hyoung-Chun Kim pp.1575-1587

Potential therapeutic agents against Alzheimer's disease from natural sources So-Young Park pp.1589-1609

Neuroprotective phenolics in medicinal plants Young Choong Kim pp.1611-1632

Site-directed mutagenesis of the toxin from the Chinese scorpion buthus martensii karsch (BmKAS) :insight into sites related to analgesic activity Yong Cui ;Yong-Bo Song ;Lin Ma ;Yan-Feng Liu ;Guo-Dong Li ;Chun-Fu Wu ;Jing-Hai Zhang pp.1633-1639

Synthesis and biological evaluation of 3,6-diaryl-7H-thiazolo[3,2-b] [1,2,4]triazin-7-one derivatives as acetylcholinesterase inhibitors Zhe Jin ;Liu Yang ;Si-Jie Liu ;Jian Wang ;Shuo Li ;Huang-Quan Lin ;David Chi Cheong Wan ;Chun Hu pp.1641-1649

Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity Yun-hyeok Choi ;Seong Su Hong ;Yu Su Shin ;Bang Yeon Hwang ;So-Young Park ;Dongho Lee pp.1651-1654

Leaf and stem of Vitis amurensis and its active components protect against amyloid β protein (25-35)-induced neurotoxicity Ha Yeon Jeong ;Joo Youn Kim ;Hong Kyu Lee ;Do Thi Ha ;Kyung-Sik Song ;KiHwan Bae ;Yeon Hee Seong pp.1655-1664

Cholinesterase inhibitors from Cleistocalyx operculatus buds Byung Sun Min ;To Dao Cuong ;Joo-Sang Lee ;Beom-Soo Shin ;Mi Hee Woo ;Tran Mahn Hung pp.1665-1670

Effect of oseltamivir on catecholamines and select oxidative stress markers in the presence of oligoelements in the rat brain David Calderón Guzmán ;Ernestina Hernández Garcia ;Norma Osnaya Brizuela ;Francisca Trujillo Jim pp.1671-1677

(The)regulation of blood glucose level in physical and emotional stress models :possible involvement of adrenergic and glucocorticoid systems Yun-Beom Sim ;Soo-Hyun Park ;Yu-Jung Kang ;Seon-Mi Kim ;Jin-Koo Lee ;Jun-Sub Jung ;Hong-Won Suh pp.1679-1683

(The)effects of daidzin and its aglycon, daidzein, on the scopolamine-induced memory impairment in male mice Dong Hyun Kim ;Hyun Ah Jung ;Se Jin Park ;Jong Min Kim ;Seungjoo Lee ;Jae Su Choi ;Jae Hoon Cheong ; pp.1685-1690

(The)combination of naproxen and citral reduces nociception and gastric damage in rats Mario I. Ortiz ;Martha L. Ramirez-Montiel ;Martha P. González-Garcia ;Héctor A. Ponce-Monter ;Gilb pp.1691-1697

Deciphering Neuropharmacology : From Basic Neurobiology to New Drug Development Chang Hoon Lee, Suk Kyeong Lee, Joo Young Lee pp.1463-1466

참고문헌 (99건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Neocortical epileptogenesis in vitro: studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands. 네이버 미소장
2 Dextromethorphan An Overview of Safety Issues 네이버 미소장
3 ANESTHESIOLOGY 네이버 미소장
4 Dextromethorphan protects against cerebral injury following transient, but not permanent, focal ischemia in rats 네이버 미소장
5 Oral administration of dextromethorphan does not produce neuronal vacuolation in the rat brain 네이버 미소장
6 A novel effect of an opioid receptor antagonist, naloxone, on the production of reactive oxygen species by microglia: a study by electron paramagnetic resonance spectroscopy 네이버 미소장
7 Non-competitive N-methyl-D-aspartate antagonists protect against sound-induced seizures in DBA/2 mice 네이버 미소장
8 Chatterjie, N., Alexander, G. J., Sechzer, J. A., and Lieberman, K. W., Prevention of cocaine-induced hyperactivity by a naloxone isomer with no opiate antagonist activity. Neurochem. Res., 21, 691-693 (1996). 미소장
9 Cerebral ischemia/reperfusion injury in rat brain: effects of naloxone 네이버 미소장
10 Effect of morphine and naloxone on priming-induced audiogenic seizures in BALB/c mice. 네이버 미소장
11 Naloxone Blockade of Myocardial Ischemic Preconditioning is Stereoselective 네이버 미소장
12 Choi, D. W., Dextrorphan and dextromethorphan attenuate glutamate neurotoxicity. Brain Res., 403, 333-336 (1987). 미소장
13 Recent Trends of Drug Abuse and Drug‐Associated Deaths in Korea 네이버 미소장
14 Selective depression of [formula omitted] by dextrorphan in the hippocampal slice in rat 네이버 미소장
15 Abuse of Dextromethorphan 네이버 미소장
16 High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments. 네이버 미소장
17 Desai, S., Aldea, D., Daneels, E., Soliman, M., Braksmajer,A. S., and Kopes-Kerr, C. P., Chronic addiction to dextromethorphan cough syrup: a case report. J. Am. Board Fam. Med., 19, 320-323 (2006). 미소장
18 Intracellular and extracellular roles of S100 proteins. 네이버 미소장
19 Kindled rats are more sensitive than non-kindled rats to the behavioural effects of combined treatment with MK-801 and valproate 네이버 미소장
20 Echevarria, E., Robles, L., and Tortella, F. C., Differential profiles of putative dextromrthorphan sigma ligands in experimental seizure models. FASEB J., 4, A331 (1990). 미소장
21 Dextromethorphan, a common antitussive, reduces kindled amygdala seizures in the rat 네이버 미소장
22 Dextromethorphan inhibits NMDA-induced convulsions 네이버 미소장
23 Identification and initial characterization of high-affinity [3H]dextrorphan binding sites in rat brain. 네이버 미소장
24 Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease 네이버 미소장
25 Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease. 네이버 미소장
26 George, C. P., Goldberg, M. P., Choi, D. W., and Steinberg,G. K., Dextromethorphan reduces neocortical ischemic neuronal damage in vivo. Brain Res., 440, 375-379 (1988). 미소장
27 Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats 네이버 미소장
28 Induction of heat shock protein HSP-70 in rat retrosplenial cortex following administration of dextromethorphan 네이버 미소장
29 Discriminative stimulus effects of dextrorphan in pigeons. 네이버 미소장
30 Phencyclidine-like discriminative effects of opioids in the rat. 네이버 미소장
31 Discriminative stimulus effects of dextromethorphan in the rat. 네이버 미소장
32 Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone. 네이버 미소장
33 Dual effects of dextromethorphan on cocaine-induced conditioned place preference in mice 네이버 미소장
34 Activation of astrocytes during epileptogenesis in the absence of neuronal degeneration 네이버 미소장
35 Kim, H. C. and Jhoo, W. K., Alterations in motor activity induced by high dose oral administration of dextromethorphan throughout two consecutive generations in mice. Arch. Pharm. Res., 18, 146-152 (1995). 미소장
36 Kim, H. C., Jhoo, W. K., Kwan, M. S., and Hong, J. S., Effects of chronic dextromethorphan administration on the cellular immune responses in mice. Arch. Pharm. Res., 18, 267-270 (1995). 미소장
37 The effects of dextromethorphan on kainic acid-induced seizures in the rat. 네이버 미소장
38 Dextromethorphan alters the reinforcing effect of cocaine in the rat. 네이버 미소장
39 Dextromethorphan blocks opioid peptide gene expression in the rat hippocampus induced by kainic acid 네이버 미소장
40 Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid 네이버 미소장
41 Dextromethorphan affects cocaine-mediated behavioral pattern in parallel with a long-lasting Fos-related antigen-immunoreactivity 네이버 미소장
42 Kim, H. C., Ko, K. H., Kim, W. K., Shin, E. J., Kang, K. S.,Shin, C. Y., and Jhoo, W. K., Effects of dextromethorphan on the seizures induced by kainate and the calcium channel agonist BAY k-8644: comparison with the effects of dextrorphan. Behav. Brain Res., 120, 169-175 (2001b). 미소장
43 Anticonvulsant effects of new morphinan derivatives 네이버 미소장
44 Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice 네이버 미소장
45 New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice 네이버 미소장
46 Role of calcium in sigma-mediated neuroprotection in rat primary cortical neurons 네이버 미소장
47 Endogenous opioid system in developing normal and jimpy oligodendrocytes: mu and kappa opioid receptors mediate differential mitogenic and growth responses. 네이버 미소장
48 Molecular biology and pharmacology of cloned opioid receptors. 네이버 미소장
49 Morphine enhances amygdaloid seizures and increases inter-ictal spike frequency in kindled rats 네이버 미소장
50 Evaluation of dextromethorphan and carbetapentane as anticonvulsants and antagonists in mice 네이버 미소장
51 Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. 네이버 미소장
52 Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide. 네이버 미소장
53 Inhibition by naloxone stereoisomers of beta-amyloid peptide (1-42)-induced superoxide production in microglia and degeneration of cortical and mesencephalic neurons. 네이버 미소장
54 Responses to NMDA receptor antagonists altered by epileptogenesis 네이버 미소장
55 Dextromethorphan attenuates hypoxia-induced neuronal dysfunction in rat neocortical slices 네이버 미소장
56 Phencyclidine receptors in rat brain cortex 네이버 미소장
57 Morphinans attenuate cortical neuronal injury induced by glucose deprivation in vitro 네이버 미소장
58 Interaction of dextrorotatory opioids with phencyclidine recognition sites in rat brain membranes 네이버 미소장
59 Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons 네이버 미소장
60 Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents. 네이버 미소장
61 Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs 네이버 미소장
62 Inflammatory mechanisms associated with brain damage induced by kainic acid with special reference to the interleukin‐1 system 네이버 미소장
63 Dextromethorphan reduces intravenous cocaine self-administration in the rat 네이버 미소장
64 Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress. 네이버 미소장
65 Quirion, R., Bowen, W. D., Itzhak, Y., Junien, J. L.,Musacchio, J. M., Rothman, R. B., Su, T. P., Tam, S. W.,and Taylor, D. P., A proposal for the classification of sigma binding sites. Trends Pharmacol. Sci., 13, 85-86 (1992). 미소장
66 Inflammatory Response and Glia Activation in Developing Rat Hippocampus after Status Epilepticus 네이버 미소장
67 Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development 네이버 미소장
68 Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. 네이버 미소장
69 Roy, S. and Loh, H. H., Effects of opioids on the immune system. Neurochem. Res., 21, 1375-1386 (1996). 미소장
70 Molecular pharmacology of the opioid receptors 네이버 미소장
71 Psychopharmacological treatment of social phobia; a double blind placebo controlled study with fluvoxamine. 네이버 미소장
72 Shin, E. J., Nabeshima, T., Lee, P. H., Kim, W. K., Ko, K. H.,Jhoo, J. H., Jhoo, W. K., Cha, J. Y., and Kim, H. C., Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice. Behav. Brain Res.,151, 267-276 (2004). 미소장
73 The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. 네이버 미소장
74 Dextromethorphan attenuates trimethyltin-induced neurotoxicity via σ 1 receptor activation in rats 네이버 미소장
75 Neuropsychotoxicity of Abused Drugs : Potential of Dextromethorphan and Novel Neuroprotective Analogs of Dextromethorphan With Improved Safety Profiles in Terms of Abuse and Neuroprotective Effects 네이버 미소장
76 Naloxone-induced electrographic seizures in the primate. 네이버 미소장
77 Glial Activation Links Early‐Life Seizures and Long‐Term Neurologic Dysfunction: Evidence Using a Small Molecule Inhibitor of Proinflammatory Cytokine Upregulation 네이버 미소장
78 Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia 네이버 미소장
79 Effects of dextromethorphan on dopamine release in the nucleus accumbens: Interactions with morphine 네이버 미소장
80 Effects of Dextromethorphan, a Nonopioid Antitussive, on Development and Expression of Amygdaloid Kindled Seizures 네이버 미소장
81 Dextromethorphan and carbetapentane: centrally acting non-opioid antitussive agents with novel anticonvulsant properties 네이버 미소장
82 Tortella, F. C., Martin, D. A., Allot, C. P., Steel, J. A.,Blackburn, T. P., Loveday, B. E., and Russell, N. J.,Dextromethorphan attenuates post-ischemic hypoperfusion following incomplete global ischemia in the anesthetized rat. Brain Res., 482, 179-183 (1989a). 미소장
83 Tortella, F. C., Pellicano, M., and Bowery, N. G., Dextromethorphan and neuromodulation: old drug coughs up new activities. Trends Pharmacol. Sci., 10, 501-507 (1989b). 미소장
84 Novel anticonvulsant analogs of dextromethorphan: improved efficacy, potency, duration and side-effect profile. 네이버 미소장
85 Neuroprotection (focal ischemia) and neurotoxicity (electroencephalographic) studies in rats with AHN649, a 3-amino analog of dextromethorphan and low-affinity N-methyl-D-aspartate antagonist. 네이버 미소장
86 Dextromethorphan: cellular effects reducing neuronal hyperactivity. 네이버 미소장
87 Effects of morphine and naloxone on pilocarpine-induced convulsions in rats 네이버 미소장
88 Dextromethorphan prevents the diethyldithiocarbamate enhancement of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice 네이버 미소장
89 Brain Inflammation in Epilepsy: Experimental and Clinical Evidence 네이버 미소장
90 Interleukin-1beta Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases 네이버 미소장
91 Increased susceptibility of S100B transgenic mice to perinatal hypoxia‐ischemia 네이버 미소장
92 Massive dextromethorphan ingestion and abuse 네이버 미소장
93 Effects of route of administration on dextromethorphan pharmacokinetics and behavioral response in the rat. 네이버 미소장
94 Co-administration of dextromethorphan with methamphetamine attenuates methamphetamine-induced rewarding and behavioral sensitization. 네이버 미소장
95 Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan. 네이버 미소장
96 Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. 네이버 미소장
97 3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity. 네이버 미소장
98 3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro. 네이버 미소장
99 Computer-assisted modeling of multiple dextromethorphan and sigma binding sites in guinea pig brain. 네이버 미소장

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