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Contents

The genetic basis of panic disorder / Hae-Ran Na ; Eun-Ho Kang ; Jae-Hon Lee ; Bum-Hee Yu 1

[요약] 1

Introduction 1

Genetic epidemiology of panic disorder 1

Family studies 1

Twin studies 2

Linkage analyses 2

Association studies 2

Catechol-O-methyltransferase (COMT) 2

Serotonergic (5-hydroxy-tryptamine [5-HT] system) 3

Monoamine oxidase (MAO) 3

Cholecystokinin (CCK) 4

Other candidate systems 5

Genome-wide association study (GWAS) 5

Considerations in the genetic studies of panic disorder 5

Small sample size 5

Gender and ethnic specificity 5

Gene-gene interaction and gene-environment interaction 6

Multiple phenotypes 6

Conclusion 6

References 7

Author summary 10

초록보기

Panic disorder is one of the chronic and disabling anxiety disorders. There has been

evidence for either genetic heterogeneity or complex inheritance, with environmental

factor interactions and multiple single genes, in panic disorder’s etiology. Linkage studies

have implicated several chromosomal regions, but no research has replicated evidence for

major genes involved in panic disorder. Researchers have suggested several

neurotransmitter systems are related to panic disorder. However, to date no candidate

gene association studies have established specific loci. Recently, researchers have

emphasized genome-wide association studies. Results of two genome-wide association

studies on panic disorder failed to show significant associations. Evidence exists for

differences regarding gender and ethnicity in panic disorder. Increasing evidence suggests

genes underlying panic disorder overlap, transcending current diagnostic boundaries. In

addition, an anxious temperament and anxiety-related personality traits may represent

intermediate phenotypes that predispose to panic disorder. Future research should focus on

broad phenotypes, defined by comorbidity or intermediate phenotypes. Genome-wide

association studies in large samples, studies of gene-gene and gene-environment

interactions, and pharmacogenetic studies are needed.

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기사명 저자명 페이지 원문 목차
(The)genetic basis of panic disorder Hae-Ran Na ,Eun-Ho Kang ,Jae-Hon Lee ,Bum-Hee Yu pp.701-710

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Norovirus infections in asymptomatic food handlers in elementary schools without norovirus outbreaks in some regions of Incheon, Korea Jun-Hwan Yu ,Na-Yeon Kim ,Eun-Jung Lee ,In-Sang Jeon pp.734-739

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Determination of malignant and invasive predictors in branch duct type intraductal papillary mucinous neoplasms of the pancreas :a suggested scoring formula Dae Wook Hwang ,Jin-Young Jang ,Chang-Sup Lim ,Seung Eun Lee ,Yoo-Seok Yoon ,Young Joon Ahn ,Ho-Seong Han ,Sun-Whe Kim ,Sang Geol Kim ,Young Kook Yun ,Seong-Sik Han ,Sang-Jae Park ,Tae Jin Lim ,Koo Jung Kang ,Mun Sup Sim ,Seong Ho Choi ,Jin Seok Heo ,Dong Wook Choi ,Kyung Yul Hur ,Dong-Shik Lee ,Sung-Su Yun ,Hong-Jin Kim ,Chul Kyoon Cho ,Hyun Jong Kim ,Hee Chul Yu ,Baik Hwan Cho ,In-Sang Song pp.740-746

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Relationship between chronic kidney disease and risk of coronary heart disease in Korean men Jae-Hong Ryoo ,Soo-Geun Kim ,Byung-Seong Suh ,Dong-Il Kim ,Sung Keun Park pp.753-758

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Effect of aspirin on the expression of hepatocyte NF-κB and serum TNF-α in streptozotocin-induced type 2 diabetic rats Xiaodong Sun ,Fang Han ,Junling Yi ,Lina Han ,Ben Wang pp.765-770

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Impact of visceral adiposity measured by abdominal computed tomography on pulmonary function Young Sik Park ,Hyuk Tae Kwon ,Seung-Sik Hwang ,Seung Ho Choi ,Young Min Cho ,Jinwoo Lee ,Jae-Joon Yim pp.771-777

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Seroepidemiology of hepatitis A in Korea :changes over the past 30 years Hyunju Lee ,Hye Kyung Cho ,Jong-Hyun Kim ,Kyung-Hyo Kim pp.791-796

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Association of serum retinol binding protein 4 with adiposity and pubertal development in Korean children and adolescents Young Jun Rhie ,Byung-Min Choi ,So Hee Eun ,Chang Sung Son ,Sang Hee Park ,Kee-Hyoung Lee pp.797-802

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Effects of level of consciousness on urodynamic procedure in female cats Wen Ji Li ,Jong Min Kim ,Seung-June Oh pp.803-806

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Prostate volume has prognostic value only in pathologic T2 radical prostatectomy specimens In-Chang Cho ,Whi-An Kwon ,Jeong Eun Kim ,Jae Young Joung ,Ho Kyung Seo ,Jinsoo Chung ,Weon Seo Park ,Kang Hyun Lee pp.807-813

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참고문헌 (87건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. 네이버 미소장
2 The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication. 네이버 미소장
3 Greenberg PE, Sisitsky T, Kessler RC, Finkelstein SN, Berndt ER, Davidson JR, Ballenger JC, Fyer AJ. The economic burden of anxiety disorders in the 1990s. J Clin Psychiatry 1999; 60: 427-35. 미소장
4 Panic attacks and risk of incident cardiovascular events among postmenopausal women in the Women's Health Initiative Observational Study. 네이버 미소장
5 Relationship Between Panic Disorder and Agoraphobia 네이버 미소장
6 Psychiatric disorders in relatives of probands with panic disorder and/or major depression. 네이버 미소장
7 The DSM-IV panic disorder field trial: panic attack frequency and functional disability. 네이버 미소장
8 Horwath E, Wolk SI, Goldstein RB, Wickramaratne P, Sobin C, Adams P, Lish JD, Weissman MM. Is the comorbidity between social phobia and panic disorder due to familial cotransmission or other factors? Arch Gen Psychiatry 1995; 52: 574-82. 미소장
9 Maier W, Lichtermann D, Minges J, Oehrlein A, Franke P. A controlled family study in panic disorder. J Psychiatr Res 1993; 27 Suppl 1: 79-87. 미소장
10 Minireview: Molecular genetics in affective illness. 네이버 미소장
11 Familial aggregation and phenomenology of 'early'-onset (at or before age 20 years) panic disorder. 네이버 미소장
12 A review and meta-analysis of the genetic epidemiology of anxiety disorders. 네이버 미소장
13 The structure of genetic and environmental risk factors for anxiety disorders in men and women. 네이버 미소장
14 Linkage genome scan for loci predisposing to panic disorder or agoraphobia. 네이버 미소장
15 A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci. 네이버 미소장
16 Genome Scan for Loci Predisposing to Anxiety Disorders Using a Novel Multivariate Approach: Strong Evidence for a Chromosome 4 Risk Locus 네이버 미소장
17 Maron E, Hettema JM, Shlik J. Advances in molecular genetics of panic disorder. Mol Psychiatry 2010; 15: 681-701. 미소장
18 Results of a genome-wide genetic screen for panic disorder. 네이버 미소장
19 Genomewide survey of panic disorder. 네이버 미소장
20 Anxiety with panic disorder linked to chromosome 9q in Iceland. 네이버 미소장
21 Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions. 네이버 미소장
22 Potential panic disorder syndrome: clinical and genetic linkage evidence. 네이버 미소장
23 Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype. 네이버 미소장
24 Further Genetic Evidence for a Panic Disorder Syndrome Mapping to Chromosome 13q 네이버 미소장
25 Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. 네이버 미소장
26 Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22. 네이버 미소장
27 Catechol O-methyltransferase genetic polymorphism in panic disorder. 네이버 미소장
28 Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women 네이버 미소장
29 Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder. 네이버 미소장
30 No association between anxiety disorders and catechol- O-methyltransferase polymorphism 네이버 미소장
31 Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. 네이버 미소장
32 Wray NR, James MR, Dumenil T, Handoko HY, Lind PA, Montgomery GW, Martin NG. Association study of candidate variants of COMT with neuroticism, anxiety and depression. Am J Med Genet B Neuropsychiatr Genet 2008; 147B: 1314-8. 미소장
33 The association between panic disorder and the L/L genotype of catechol-O-methyltransferase 네이버 미소장
34 Zintzaras E, Sakelaridis N. Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder? Psychiatr Genet 2007; 17: 267-73. 미소장
35 Domschke K, Deckert J, O’Donovan MC, Glatt SJ. Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity. Am J Med Genet B Neuropsychiatr Genet 2007; 144B: 667-73. 미소장
36 Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles. 네이버 미소장
37 Different properties of the central and peripheral forms of human tryptophan hydroxylase 네이버 미소장
38 Tryptophan hydroxylase and serotonin transporter gene polymorphism does not affect the diagnosis, clinical features and treatment outcome of panic disorder in the Korean population 네이버 미소장
39 Associations between serotonin-related gene polymorphisms and panic disorder 네이버 미소장
40 The association between serotonin-related gene polymorphisms and panic disorder 네이버 미소장
41 The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder. 네이버 미소장
42 Kim YK, Lee HJ, Yang JC, Hwang JA, Yoon HK. A tryptophan hydroxylase 2 gene polymorphism is associated with panic disorder. Behav Genet 2009; 39: 170-5. 미소장
43 Association study of tryptophan hydroxylase 2 gene polymorphisms in panic disorder. 네이버 미소장
44 An association study between a transcriptional polymorphism in the serotonin transporter gene and panic disorder in a Japanese population 네이버 미소장
45 Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis. 네이버 미소장
46 The symptomatic profile of panic disorder is shaped by the 5-HTTLPR polymorphism 네이버 미소장
47 Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR). 네이버 미소장
48 Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder. 네이버 미소장
49 Association between a promoter variant in the monoamine oxidase A gene and schizophrenia. 네이버 미소장
50 Excess of High Activity Monoamine Oxidase A Gene Promoter Alleles in Female Patients with Panic Disorder 네이버 미소장
51 Hamilton SP, Slager SL, Heiman GA, Haghighi F, Klein DF, Hodge SE, Weissman MM, Fyer AJ, Knowles JA. No genetic linkage or association between a functional promoter polymorphism in the monoamine oxidase- A gene and panic disorder. Mol Psychiatry 2000; 5: 465-6. 미소장
52 New peptide in the vertebrate CNS reacting with antigastrin antibodies. 네이버 미소장
53 Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder. 네이버 미소장
54 No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder. 네이버 미소장
55 Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder. 네이버 미소장
56 Gene variations in the cholecystokinin system in patients with panic disorder. 네이버 미소장
57 Peripheral administration of cholecystokinin activates c-fos expression in the locus coeruleus/subcoeruleus nucleus, dorsal vagal complex and paraventricular nucleus via capsaicin-sensitive vagal afferents and CCK-A receptors in the rat 네이버 미소장
58 Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse 네이버 미소장
59 Miyasaka K, Yoshida Y, Matsushita S, Higuchi S, Shirakawa O, Shimokata H, Funakoshi A. Association of cholecystokinin-A receptor gene polymorphisms and panic disorder in Japanese. Am J Med Genet B Neuropsychiatr Genet 2004; 127B: 78-80. 미소장
60 Kennedy JL, Bradwejn J, Koszycki D, King N, Crowe R, Vincent J, Fourie O. Investigation of cholecystokinin system genes in panic disorder. Mol Psychiatry 1999; 4: 284-5. 미소장
61 Ise K, Akiyoshi J, Horinouchi Y, Tsutsumi T, Isogawa K, Nagayama H. Association between the CCK-A receptor gene and panic disorder. Am J Med Genet B Neuropsychiatr Genet 2003; 118B: 29-31. 미소장
62 The Human Gastrin/Cholecystokinin Type B Receptor Gene: Alternative Splice Donor Site in Exon 4 Generates Two Variant mRNAs 네이버 미소장
63 Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder 네이버 미소장
64 Hattori E, Ebihara M, Yamada K, Ohba H, Shibuya H, Yoshikawa T. Identification of a compound short tandem repeat stretch in the 5’-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia. Mol Psychiatry 2001; 6: 465-70. 미소장
65 Missense mutation of the cholecystokinin B receptor gene: lack of association with panic disorder. 네이버 미소장
66 The HapMap and genome-wide association studies in diagnosis and therapy. 네이버 미소장
67 Replication of a genome-wide association study of panic disorder in a Japanese population 네이버 미소장
68 Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum 네이버 미소장
69 Interaction of serotonergic and noradrenergic gene variants in panic disorder. 네이버 미소장
70 Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. 네이버 미소장
71 Association between ADORA2A and DRD2 Polymorphisms and Caffeine-Induced Anxiety 네이버 미소장
72 Association of the Anxiogenic and Alerting Effects of Caffeine with ADORA2A and ADORA1 Polymorphisms and Habitual Level of Caffeine Consumption 네이버 미소장
73 Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders. 네이버 미소장
74 Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism 네이버 미소장
75 Phobic, panic, and major depressive disorders and the five-factor model of personality. 네이버 미소장
76 Harm avoidance and self-directedness as essential features of panic disorder patients 네이버 미소장
77 Behavioral inhibition and history of childhood anxiety disorders in Brazilian adult patients with panic disorder and social anxiety disorder. 네이버 미소장
78 Rosenbaum JF, Biederman J, Hirshfeld DR, Bolduc EA, Chaloff J. Behavioral inhibition in children: a possible precursor to panic disorder or social phobia. J Clin Psychiatry 1991; 52 Suppl: 5-9. 미소장
79 Childhood history of behavioral inhibition and comorbidity status in 256 adults with social phobia. 네이버 미소장
80 Behavioral inhibition 네이버 미소장
81 Behavioral Inhibition in Childhood: A Risk Factor for Anxiety Disorders 네이버 미소장
82 Behavioral Inhibition in Children of Parents With Panic Disorder and Agoraphobia 네이버 미소장
83 A controlled study of behavioral inhibition in children of parents with panic disorder and depression. 네이버 미소장
84 Behavioral inhibition: linking biology and behavior within a developmental framework. 네이버 미소장
85 Inhibited and Uninhibited Infants "Grown up": Adult Amygdalar Response to Novelty 네이버 미소장
86 The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder. 네이버 미소장
87 Evidence for a Gene-Environment Interaction in Predicting Behavioral Inhibition in Middle Childhood 네이버 미소장

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