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Background: Annexin A1 (ANXA1) is known to be involved in the progression and differentiation of various tumors. However, its significance and role in bladder carcinogenesis has not been fully elucidated. To determine the role ANXA1 plays in urothelial carcinoma (UC), we investigated the expression of ANXA1 protein in normal urothelial tissue, carcinoma in situ (CIS), and UC of the urinary bladder. Methods: Protein expression level of ANXA1 and its subcellular localization were analyzed in 88 cases of UCs and corresponding 24 normal tissues and 24 CISs by immunohistochemistry. Results: ANXA1 was significantly down-regulated at all subcellular localization in CIS and in the cytoplasm and membrane of cells of UC, compared to normal tissues. No significant correlation between ANXA1 expression level and tumor depth (pT), growth pattern, and recurrence was found. However, cytoplasmic and membranous ANXA1 were significantly up-regulated in high grade than in low grade UC (p=0.02 in cytoplasm and p=0.03 in membrane). Conclusions: These results suggest that ANXA1 dysregulation is involved in urothelial carcinogenesis and ANXA1 is potentially a marker for the pathologic differentiation of UC.

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TCDD에 노출된 갑상샘 유두암종 세포주에서 선택적 Cyclooxygenase 2 억제제의 효과 김해성 ,안광성 ,이정현 ,채양석 ,원남희 ,최종상 ,김철환 pp.1-8

한국과 미국에서의 병리조직검사 상대가치 비교연구 황일선 ,강유나 ,권건영 ,권선영 ,김상표 ,이상숙 ,정혜라 ,최미선 pp.9-14

Prognostic implications of the expression of CXCL16 in breast carcinoma Dong-Youl Choi ,Ran Hong ,Sung-Churl Lim ,Keun-Hong Kee ,Chae-Hong Suh ,Mija Lee pp.15-20

아교모세포종에서 메틸화특이적 중합효소연쇄반응과 Pyrosequencing을 이용한 MGMT 유전자 프로모터 메틸화 분석에 대한 고찰 이상화 ,황태숙 ,고영초 ,김욱연 ,한혜승 ,김완섭 ,고영신 ,임소덕 pp.21-29

Use of calretinin, CD56, and CD34 for differential diagnosis of schwannoma and neurofibroma Ji Young Park ,Hoon Park ,Nam Jo Park ,June Sik Park ,Hyun-Jung Sung ,Sang Sook Lee pp.30-35

Pathologic differences between placentas from intrauterine growth restriction pregnancies with and without absent or reversed end diastolic velocity of umbilical arteries Changyoung Yoo ,Dong Gyu Jang ,Yun Sung Jo ,Jinyoung Yoo ,Guisera Lee pp.36-44

ERCC1 predicts a poorer platinum-based chemotherapy outcome but a better outcome for uracil-tegafur in the resected stage Ⅰ-Ⅱ NSCLC Han Suk Ryu ,Xianhua Xu ,Hyojin Kim ,Jong-Suk Lee ,Sanghoon Jheon ,Jin-Haeng Chung pp.45-52

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(The)expression pattern of annexin A1 in urinary bladder urothelial carcinoma and its clinicopathologic significance Hojung Lee ,Seung Kyu Choi ,Young Ok Hong ,Won Mi Lee ,Sook Kyung Ko ,Eun Kyung Kim ,Jong Eun Joo pp.62-68

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(A)case of ovarian microinvasive mucinous carcinoma and co-existent angiosarcoma Jin Hyung Heo ,Yoon Hee Lee ,Gwang Il Kim ,Tae Heon Kim ,Haeyoun Kang ,Hee Jung An ,Bo Sung Yoon ,Seok Ju Seong ,Hyun Park ,Ji Young Kim pp.96-100

Langerhans cell sarcoma arising in a lymph node :a case report and review of the literature Dong-Wook Kang ,Hyun-Jin Son ,Tae-Hwa Baek ,Hye-Kyung Lee ,Joo-Ryung Huh ,Joo-Heon Kim ,Mee-Ja Park pp.101-105

Sclerosing angiomatoid nodular transformation(SANT) in spleen :a case report Hyun-Jung Lee ,Song-Yi Choi ,Song Mei Huang ,Ji-Young Sul ,Jin-Man Kim pp.111-114

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참고문헌 (28건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Annexins Possess Functionally Distinguishable Ca 2+ and Phospholipid Binding Domains 네이버 미소장
2 Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins. 네이버 미소장
3 Evaluation of the antiinflammatory and phospholipase-inhibitory activity of calpactin II/lipocortin I. 네이버 미소장
4 Inhibition of phospholipase A2 activity of guinea-pig alveolar macrophages by lipocortin-like proteins purified from mice lung 네이버 미소장
5 Croxtall J, Flower R, Perretti M. The role of lipocortin 1 in the regulation of A549 cell proliferation and leukocyte migration. J Lipid Mediat 1993; 6: 295-302. 미소장
6 Modulation of Cell Death Pathways to Apoptosis and Necrosis of H 2O 2-Treated Rat Thymocytes by Lipocortin I 네이버 미소장
7 Annexin I modulates cell functions by controlling intracellular calcium release. 네이버 미소장
8 The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells 네이버 미소장
9 Enhanced expression of the protein kinase substrate annexin in human hepatocellular carcinoma 네이버 미소장
10 Bai XF, Ni XG, Zhao P, et al. Overexpression of annexin 1 in pancreatic cancer and its clinical significance. World J Gastroenterol 2004; 10: 1466-70. 미소장
11 Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1) 네이버 미소장
12 Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma. 네이버 미소장
13 Dysregulation of annexin I protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. 네이버 미소장
14 Absence of annexin I expression in B-cell non-Hodgkin's lymphomas and cell lines 네이버 미소장
15 Annexin 1: Differential expression in tumor and mast cells in human larynx cancer 네이버 미소장
16 The Nuclear Location of Annexin V in the Human Osteosarcoma Cell Line MG-63 Depends on Serum Factors and Tyrosine Kinase Signaling Pathways 네이버 미소장
17 Specific association of annexin 1 with plasma membrane-resident and internalized EGF receptors mediated through the protein core domain 네이버 미소장
18 Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma 네이버 미소장
19 Down-regulation of plasma membranous Annexin A1 protein expression in premalignant and malignant lesions of the oral cavity: correlation with epithelial differentiation. 네이버 미소장
20 Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007; 57: 43-66. 미소장
21 A Case–Control Study of Smoking and Bladder Cancer Risk: Emergent Patterns Over Time 네이버 미소장
22 Urothelial tumorigenesis: a tale of divergent pathways. 네이버 미소장
23 Overexpression of annexin a1 induced by terephthalic acid calculi in rat bladder cancer. 네이버 미소장
24 Annexin-I overexpression is associated with tumour progression and independently predicts inferior disease-specific and metastasis-free survival in urinary bladder urothelial carcinoma. 네이버 미소장
25 Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study 네이버 미소장
26 Annexin A1 subcellular expression in laryngeal squamous cell carcinoma 네이버 미소장
27 Annexin 1: the new face of an old molecule. 네이버 미소장
28 Expression of annexin A1 in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome. 네이버 미소장

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