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Background: The clinical manifestation of M. tuberculosis infection ranges from asymptomatic latent infection, to focal forms with minimal symptoms and low bacterial burdens, and finally to advanced tuberculosis (TB) with severe symptoms and high bacillary loads. We investigated the diagnostic sensitivity of the whole-blood interferon-γ release assay according to the wide spectrum of clinical phenotypes.

Methods: In patients diagnosed with active TB that underwent QuantiFERON^ⓡ (QFT) testing, the QFT results were compared with patients known to be infected with pulmonary tuberculosis (P-TB) and extra-pulmonary TB (EP-TB). In addition, the results of the QFT test were further analyzed according to the radiographic extent of disease in patients with P-TB and the location of disease in patients with EP-TB.

Results: There were no statistical differences in the overall distribution of QFT results between 177 patients with P-TB and 84 patients with EP-TB; the positive results of QFT test in patients with P-TB and EP-TB were 70.1% and 64.3%, respectively. Among patients with P-TB, patients with mild extents of disease showed higher frequency of positive results of QFT test than that of patients with severe form (75.2% vs. 57.1%, respectively; p=0.043) mainly due to an increase of indeterminate results in severe P-TB. Patients with TB pleurisy showed lower sensitivity by the QFT test than those with tuberculous lymphadenitis (48.8% vs. 78.8%, respectively; p=0.019).

Conclusion: Although QFT test showed similar results between overall patients with P-TB and EP-TB, individual sensitivity was different according to the radiographic extent of disease in P-TB and the location of disease in EP-TB.

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기사명 저자명 페이지 원문 목차
의료기관관련 폐렴 이흥범 ,한효진 pp.105-112

(The)macrophage-specific transcription factor can be modified posttranslationally by ubiquitination in the lipopolysaccharide-treated macrophages Jae Woo Jung ,Jae Chol Choi ,Jae Yeol Kim ,In Won Park ,Byoung Whui Choi ,Jong Wook Shin ,John William Christman pp.113-124

활동성 결핵의 중증도 및 병변 부위에 따른 전혈 인터페론 감마 분비능 측정의 민감도 김이영 ,이재희 ,이윤지 ,이소연 ,이용훈 ,최금주 ,황보엽 ,차승익 ,박재용 ,정태훈 ,박준식 ,김창호 pp.125-131

비소세포폐암에서 Maspin의 발현과 임상적 의의 윤성훈 ,김원진 ,신경화 ,김미현 ,조우현 ,김기욱 ,박혜경 ,전두수 ,김윤성 ,이창훈 ,이민기 ,박순규 pp.132-138

Cutaneous metastasis from lung cancer :a single-institution retrospective analysis Jong Hwan Lee ,Se Jin Ahn ,Hyung Jin Kim ,Sang Eon Jang ,Geum Youb Noh ,Hye-Ryoun Kim ,Cheol Hyeon Kim ,Jae Cheol Lee pp.139-142

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다발성 폐결절로 발견된 카플란증후군 1예 이상국 ,이상훈 ,김송이 ,이우경 ,신동호 ,방우대 ,노송미 ,심효섭 ,박병훈 ,이경종 ,박무석 ,김영삼 ,장준 ,김세규 ,강영애 pp.150-154

(A)case of novel influenza A(H1N1) virus pneumonia complicated pnemomediastinum and subcutenous emphysema Yu Jin Kim ,Sung-Young Kyung ,Jung-Woong Park ,Sung Hwan Jeong ,Yiel-Hea Seo ,Sang-Pyo Lee pp.155-159

비소세포폐암 환자에서 부종양성 증후군의 증상으로 발생한 좌측 3, 4 뇌신경 마비 1예 이영미 ,심우호 ,윤선옥 ,김송이 ,박정수 ,고보건 ,변민광 ,최영철 ,김형중 pp.160-164

중간 세로칸 악성 곁신경절종 박성범 ,박실비아 ,방선하 ,김은경 ,전경만 ,고원중 ,서지영 ,정만표 ,김호중 ,권오정 ,고영혜 ,엄상원 pp.165-169

참고문헌 (25건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Updated Guidelines for Using Interferon Gamma Release Assays to Detect Mycobacterium tuberculosis Infection — United States, 2010 네이버 미소장
2 Clinical Utility of Interferon Gamma Assay in the Diagnosis of Tuberculosis 네이버 미소장
3 Systematic Review: T-Cell-based Assays for the Diagnosis of Latent Tuberculosis Infection: An Update 네이버 미소장
4 T-cell interferon-gamma release assays for the rapid immunodiagnosis of tuberculosis: clinical utility in high-burden vs. low-burden settings. 네이버 미소장
5 The Diagnosis of Tuberculosis 네이버 미소장
6 Use of adenosine deaminase as a diagnostic tool for tuberculous pleurisy. 네이버 미소장
7 Indeterminate results of QuantiFERON TB-2G test performed in routine clinical practice. 네이버 미소장
8 Transitional changes in T-cell responses to Mycobacterium tuberculosis-specific antigens during treatment. 네이버 미소장
9 Use in routine clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium tuberculosis: a prospective study 네이버 미소장
10 Nishimura T, Hasegawa N, Mori M, Takebayashi T, Harada N, Higuchi K, et al. Accuracy of an interferon- gamma release assay to detect active pulmonary and extra-pulmonary tuberculosis. Int J Tuberc Lung Dis 2008;12:269-74. 미소장
11 Use of ESAT-6 and CFP-10 Antigens for Diagnosis of Extrapulmonary Tuberculosis 네이버 미소장
12 Prospective evaluation of a whole-blood test using Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10 for diagnosis of active tuberculosis. 네이버 미소장
13 Use of a T cell interferon gamma release assay in the investigation for suspected active tuberculosis in a low prevalence area. 네이버 미소장
14 Low sensitivity of a whole-blood interferon-gamma release assay for detection of active tuberculosis. 네이버 미소장
15 Clinical correlates of interferon gamma production in patients with tuberculosis. 네이버 미소장
16 Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment. 네이버 미소장
17 Region of Difference 1 Antigen–Specific CD4+ Memory T Cells Correlate with a Favorable Outcome of Tuberculosis 네이버 미소장
18 Usefulness of the whole-blood interferon-gamma release assay for diagnosis of extrapulmonary tuberculosis 네이버 미소장
19 The Usefulness of Whole-blood Interferon-gamma Release Assay for the Diagnosis of Extra-pulmonary Tuberculosis 소장
20 Can pleural tuberculosis be diagnosed using interferon-gamma release assays? 네이버 미소장
21 Cytokine production at the site of disease in human tuberculosis. 네이버 미소장
22 Sequestration of T Lymphocytes to Body Fluids in Tuberculosis: Reversal of Anergy following Chemotherapy 네이버 미소장
23 T-Helper Type 1/T-Helper Type 2 Balance in Malignant Pleural Effusions Compared to Tuberculous Pleural Effusions 네이버 미소장
24 Evaluation 네이버 미소장
25 Evaluation of adapted whole-blood interferon-gamma release assays for the diagnosis of pleural tuberculosis. 네이버 미소장

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