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There are many limitations for conducting liver disease research in human beings due to the high cost and potential ethical issues. For this reason, conducting a study that is difficult to perform in humans using appropriate animal models, can be beneficial in ascertaining the pathological physiology, and in developing new treatment modalities. However, it is difficult to determine the appropriate animal model which is suitable for research purposes, since every patient has different and diverse clinical symptoms, adverse reactions, and complications due to the pathological physiology. Also, it is not easy to reproduce identically various clinical situations in animal models. Recently, the Guide for the Care and Use of Laboratory Animals has tightened up the regulations, and therefore it is advisable to select the appropriate animals and decide upon the appropriate quantities through scientific and systemic considerations before conducting animal testing. Therefore, in this review article the authors examined various white rat animal testing models and determined the appropriate usable rat model, and the pros and cons of its application in liver disease research. The authors believe that this review will be beneficial in selecting proper laboratory animals for research purposes.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Ideal experimental rat models for liver diseases Sang Woo Lee ,Sung Hoon Kim ,Seon Ok Min ,Kyung Sik Kim pp.67-77

Liver transplantation in liver cirrhosis patients accompanied by portal vein thrombosis Bong-Wan Kim pp.78-82

Risk factors for intrahepatic recurrence Myung Hee Yoon ,Young Il Choi ,KwangKuk Park ,Dong Hoon Shin ,Chung Han Lee pp.83-89

Outcome of hepatectomy for huge hepatocellular carcinoma Sungho Jo pp.90-100

Anatomical variation of the glissonean pedicle of the right liver Weiguang Xu ,Hee Jung Wang ,Bong-Wan Kim ,Yong-Keun Park ,Guangyi Li pp.101-106

Effect of liver cell transplantation on acute hepatic failure induced by massive liver resection in the rat Jung Hyun Park ,Young Chul Yoon ,Tae Ho Hong ,Young Kyoung You ,Dong Goo Kim pp.107-116

Comparison of bile drainage methods after laparoscopic CBD exploration Seong Uk Kwon ,In Seok Choi ,Ju Ik Moon ,Yu Mi Ra ,Sang Eok Lee ,Won Jun Choi ,Dae Sung Yoon ,Hyun Sik Min pp.117-122

Pancreatic diabetes after distal pancreatectomy :incidence rate and risk factors Ka-Jeong Kim ,Chi-Young Jeong ,Sang-Ho Jeong ,Young-Tae Ju ,Eun-Jung Jung ,Young-Joon Lee ,Sang-Kyung Choi ,Woo-song Ha ,Soon-Tae Park ,Soon-Chan Hong pp.123-127

Fat tissue infiltration into the pancreas parenchyme and its effect on the result of surgery Sang Ho Yoon ,Eung-Ho Cho ,Sang Bum Kim ,Sun-Hoo Park pp.128-133

Serous cystic neoplasm :do we have to wait till it causes trouble? Ho Kyoung Hwang ,Young Eun Chung ,Hyun Ki Kim ,Jung Yub Park ,Hye Jin Choi ,Chang Moo Kang ,Woo Jung Lee pp.134-138

참고문헌 (77건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 The Daedalus effect: changes in ethical questions relating to hepatitis B virus. 네이버 미소장
2 Problems with animal models of chronic liver disease: suggestions for improvement in standardization. 네이버 미소장
3 An improved model of acute liver failure based on transient ischemia of the liver. 네이버 미소장
4 Animal models of fulminant hepatic failure:A critical evaluation 네이버 미소장
5 Terblanche J, Hickman R. Animal models of fulminant hepatic failure. Dig Dis Sci 1991;36:770-774. 미소장
6 Hedrich HJ. Taxonomy and Stocks and strains. In The Laboratory Rat. 2nd ed. Amsterdam; Boston: Elsevier; 2006. 미소장
7 Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase. 네이버 미소장
8 The Long–Evans Cinnamon rat: An animal model for Wilson’s disease 네이버 미소장
9 High susceptibility of an analbuminemic congenic strain of rats with an F344 genetic background to induced bladder cancer and its possible mechanism. 네이버 미소장
10 Cubero FJ, Arza E, Maganto P, et al. Expression of bilirubin UDP-glucuronosyltransferase (bUGT) throughout fetal development: intrasplenic transplantation into Gunn rats to correct enzymatic deficiency. Dig Dis Sci 2001;46:2762-2767. 미소장
11 Biochemical and molecular aspects of genetic disorders of bilirubin metabolism. 네이버 미소장
12 Orthotopic liver transplantation for type I Crigler-Najjar syndrome 네이버 미소장
13 Orthotopic liver transplantation for Crigler-Najjar type I disease in six children. 네이버 미소장
14 Progressive histological damage in liver allografts following pediatric liver transplantation 네이버 미소장
15 Gunn rat: a model for inherited deficiency of bilirubin glucuronidation. 네이버 미소장
16 Inhibition of the copper incorporation into ceruloplasmin leads to the deficiency in serum ceruloplasmin activity in Long-Evans cinnamon mutant rat. 네이버 미소장
17 New mutation causing hereditary hepatitis in the laboratory rat. 네이버 미소장
18 A new rat model for the study of hepatocarcinogenesis 네이버 미소장
19 Stat proteins and oncogenesis. 네이버 미소장
20 Harmful effect of administration of copper on LEC rats. 네이버 미소장
21 Hereditary low level of plasma ceruloplasmin in LEC rats associated with spontaneous development of hepatitis and liver cancer. 네이버 미소장
22 Bennhold H. Two cases of familial analbuminemia. Mar Med 1959;38:863-872. 미소장
23 Analbuminemia in a neonate 네이버 미소장
24 Failure of liver cirrhosis induction by thioacetamide in Nagase analbuminaemic rats. 네이버 미소장
25 Establishment and characteristics of three analbuminemic congenic strains of rats. 네이버 미소장
26 Organic anion transport study in mutant rats with autosomal recessive conjugated hyperbilirubinemia 네이버 미소장
27 Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats. 네이버 미소장
28 A new rat mutant with chronic conjugated hyperbilirubinemia and renal glomerular lesions. 네이버 미소장
29 Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat 네이버 미소장
30 Effects of organic anions and bile acids on biliary lipid excretion in hyperbilirubinemic mutant Sprague-Dawley rats 네이버 미소장
31 Establishment of an albumin-deficient and jaundiced strain of rats. 네이버 미소장
32 Tonnesen K. Experimental liver failure. A comparison between hepatectomy and hepatic devascularization in the pig. Acta Chir Scand 1977;143:271-277. 미소장
33 Extent of Hepatectomy in the Rat 네이버 미소장
34 Progressive necrosis after hepatectomy and the pathophysiology of liver failure after massive resection 네이버 미소장
35 Fischer M, Stotter L, Schmahl W, Gartmaier P, Erhardt W. Acute liver failure due to temporary hepatic ischemia in the pig. Acta Hepatogastroenterol (Stuttg) 1976;23:241-249. 미소장
36 Apoptosis after ischemia-reperfusion in human liver allografts 네이버 미소장
37 Prostacyclin, thromboxane, and oxygen free radicals and postoperative liver function in human liver transplantation. 네이버 미소장
38 Intermittent Anoxia Reduces Oxygen Free Radicals Formation During Reoxygenation in Rat Hepatocytes 네이버 미소장
39 Up-regulation of oxygen-derived free radicals by interleukin-1 in hepatic ischemia/reperfusion injury. 네이버 미소장
40 Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. 네이버 미소장
41 Chang ML, Yeh CT, Chang PY, Chen JC. Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation. World J Gastroenterol 2005;11:4167-4172. 미소장
42 Experimental hepatitis induced by D-galactosamine. 네이버 미소장
43 Keppler D, Decker K. Mechanism of action of D-galactosamine in the liver. Verh Dtsch Ges Inn Med 1971;77: 1182-1185. 미소장
44 In-vitro preparation of experimental models of hepatitis with D-galactosamine and their modification by liver-repairing factors. 네이버 미소장
45 Protection from T cell-mediated murine liver failure by phosphodiesterase inhibitors. 네이버 미소장
46 The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure. 네이버 미소장
47 Systemic and hepatic hemodynamic changes in acute liver injury. 네이버 미소장
48 Acetaminophen hepatotoxicity. 네이버 미소장
49 Liver necrosis from paracetamol. 네이버 미소장
50 The chronic oral toxicity of paracetamol at the range of the LD50 (100 days) in albino rats. 네이버 미소장
51 Acute Liver Necrosis Following Overdose Of Paracetamol 네이버 미소장
52 Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine. 네이버 미소장
53 Acetaminophen-induced Hepatic Necrosis 네이버 미소장
54 Metabolic oxidation of acetaminophen (Paracetamol) mediated by cytochrome P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidney 네이버 미소장
55 Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat. 네이버 미소장
56 Hepatotoxicity of acetaminophen in neonatal and young rats 네이버 미소장
57 Hepatotoxicity of acetaminophen in neonatal and young rats 네이버 미소장
58 Gregus Z, Madhu C, Goon D, Klaassen CD. Effect of galactosamine-induced hepatic UDP-glucuronic acid depletion on acetaminophen elimination in rats. Dispositional differences between hepatically and extrahepatically formed glucuronides of acetaminophen and other chemicals. Drug Metab Dispos 1988;16:527-533. 미소장
59 Hübner G. Ultrastructural liver damage caused by direct action of carbon tetrachloride in vivo and in vitro. Virchows Arch Pathol Anat Physiol Klin Med 1965;339:187-197. 미소장
60 Smith DH. Carbon tetrachloride toxicity. Br Med J 1965;2:1434. 미소장
61 Hepatocellular tolerance to carbon tetrachloride induced injury in the rat: a study of its nature and possible mode of evolution. 네이버 미소장
62 Evidence of Hepatocyte Apoptosis in Rat Liver after the Administration of Carbon Tetrachloride 네이버 미소장
63 Thioacetamide- and carbon tetrachloride-induced liver cirrhosis. 네이버 미소장
64 Bone changes and mineral metabolism disorders in rats with experimental liver cirrhosis. 네이버 미소장
65 New data on the question of lipoperoxidation in carbon tetrachloride poisoning. 네이버 미소장
66 Slater TF, Strauli UD, Sawyer BC. Changes in liver nucleotide concentrations in experimental liver injury. 1. Carbon tetrachloride poisoning. Biochem J 1964;93:260-266. 미소장
67 A study of the relationships between carbon tetrachloride-induced lipid peroxidation and liver damage in rats pretreated with vitamin E 네이버 미소장
68 Lipoperoxidation of rat liver microsomal lipids induced by carbon tetrachloride. 네이버 미소장
69 Acute renal failure due to carbon tetrachloride poisoning. 네이버 미소장
70 Carbon tetrachloride nephrotoxicity: a reassessment of pathophysiology based upon the urinary diagnostic indices. 네이버 미소장
71 Role of the microsomal fad-containing monooxygenase in the liver toxicity of thioacetamide S-oxide 네이버 미소장
72 Bruck R, Oren R, Shirin H, et al. Hypothyroidism minimizes liver damage and improves survival in rats with thioacetamide induced fulminant hepatic failure. Hepatology 1998;27:1013- 1020. 미소장
73 Cerebral metabolic and histological effects of thioacetamide-induced liver failure. 네이버 미소장
74 Hepatic encephalopathy in thioacetamide-induced acute liver failure in rats: characterization of an improved model and study of amino acid-ergic neurotransmission. 네이버 미소장
75 Serum amino acid changes in rats with thioacetamide-induced liver cirrhosis 네이버 미소장
76 Phagocytic function and metabolite production in thioacetamide-induced liver cirrhosis: a comparative study in perfused livers and cultured Kupffer cells 네이버 미소장
77 The development of an efficient rat hepatic cirrhosis model 네이버 미소장

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