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Contents
Fulminant epstein-barr virus-associated T-cell lymphoproliferative disorder in an immunocompetent middle-aged man presenting with chronic diarrhea and gastrointestinal bleeding / Jamshid Abdul-Ghafar ; Jae Woo Kim ; Kwang Hwa Park ; Mee-Yon Cho 1
[요약] 1
Introduction 1
Case description 1
Discussion 3
References 5
The World Health Organization (WHO) recently defined systemic Epstein-Barr virus (EBV)-
positive T-cell lymphoproliferative disorders (LPD) of childhood as a life-threatening illness.
However, this rare disease has not been extensively studied. Here we report a case of
systemic EBV-positive T-cell LPD in a previously healthy middle-aged man with a chief
complaint of chronic diarrhea. The initial colon biopsy showed focal infiltration of EBVpositive
small lymphocytes without any atypia. However, the disease rapidly progressed
and the patient required a total colectomy due to severe gastrointestinal bleeding. Three
and half months after admission, the patient died from a complication of disseminated
intravascular coagulation. The resected colon showed diffuse infiltration of EBV-positive
atypical lymphocytes with ischemic change. Most atypical lymphocytes were CD3_+ or
CD5_+. The monoclonality of EBV was demonstrated by sequence variation analysis of the
latent membrane protein 1 (LMP1) gene in the colectomy specimen as well as in the initial
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