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This study developed new enzyme-specific superparamagnetic iron oxide nanoparticles (SPIONs) with potential as a multimodal probe in magnetic resonance (MR) imaging and optical imaging. For the MR/optical dual imaging, SPIONs were coated with near-infrared fluorescence dye (Cy5.5)-labeled hyaluronic acid (Cy5.5-HA), which could be readily degraded by hyaluronidase (HAdase). The presence of HA on the coated SPION was confirmed using FTIR, X-ray diffraction, and thermogravimetric analysis. Physicochemical analyses of Cy5.5-HAcoated SPIONs (Cy5.5-HA-SPIONs) demonstrated their higher colloidal stability and T2 relaxivity than bare SPIONs. When Cy5.5-HA-SPIONs were exposed to the MR instrument for the phantom test, the dark intensity of their T2-weighted image increased in a Fe concentration-dependent manner, suggesting potential as the MR probe. To examine their ability as the enzyme-sensitive optical probe, the fluorescent signals of Cy5.5-HA-SPIONs were measured in the absence or presence of HAdase. In the absence of HAdase, Cy5.5-HA-SPIONs showed a negligible fluorescent signal due to possible quenching between a SPION and fluorescence dye, and self-quenching effect of Cy5.5 molecules. On the other hand, in the presence of HAdase, the fluorescent signal of Cy5.5-HA-SPIONs increased dramatically as a function of the HAdase concentration, resulting from the degradation of the HA backbone. These results suggest that the Cy5.5-HA-SPION is useful as a multimodal nanoprobe for MR imaging and HAdase-sensitive optical imaging.

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기사명 저자명 페이지 원문 목차
Color stability of conjugated polymer with difluoro groups in vinylene units Suhee Song, Sung Heum Park, Jaeyeon Jung, Chang Sik Ju, Kwanghee Lee, Hongsuk Suh, Youngeup Jin pp.753-756

Substituent effects of accelerator on nitroxide-mediated radical polymerization Jian-ying Huang ,Jia-ming Zhuang ,You-si Zou pp.757-763

Electrochemical grafting of poly(2,5-dimethoxy aniline) onto multiwalled carbon nanotubes nanocomposite modified electrode and electrocatalytic oxidation of ascorbic acid Dhanusuraman Ragupathy ,Jung Je Park ,Soo Chool Lee ,Jae Chang Kim ,Palanisamy Gomathi ,Min Kwan Kim ,So Min Lee ,Han Do Ghim ,Annamalai Rajendran ,Sang Hak Lee ,Kyung Moon Jeon pp.764-769

Controlled synthesis of branched polystyrene via free radical polymerization of novel chain transfer monomer Cui-Ping Li ,Jia-Qiang Wang ,Jun Lin ,Yan Shi ,Zhi-Feng Fu pp.770-777

Molecular characterization of polypropylene heterophasic copolymers by fractionation techniques Rafael A. Carcía, Baudilio Coto, María-Teresa Expósito, Inmaculada Suarez, Almudena Fernández-Fernández, Susana Caveda pp.778-788

Improvement in the mechanical properties of polylactide and bamboo fiber biocomposites by fiber surface modification Jun Tae Kang ,Seong Hun Kim pp.789-796

Effect of 3,5-diaminobenzoic acid content, casting solvent, and physical aging on gas permeation properties of copolyimides containing pendant acid groups R. M. Huertas, E. M. Maya, J. de Abajo, J. G. de la Campa pp.797-808

Functionalized graphene sheet/polyurethane nanocomposites :effect of particle size on physical properties Jin Taek Choi ,Dong Hoon Kim ,Kwang Sun Ryu ,Hyung-il Lee ,Han Mo Jeong ,Cheol Min Shin ,Jung Ho Kim ,Byung Kyu Kim pp.809-814

PEG/PLA core/sheel particles from coaxial electrohydrodynamic spray drying Hwanki Ho ,Jonghwi Lee pp.815-821

Oxidative stabilization of conjugated linoleic acid by one-pot PLGylation Hyun-Seuk Moon, Ji-Hye Seo, Ding-Ding Guo, Hong-Gu Lee, Prati Bajracharya, Yun-Jaie Choi, Keunsoo Jeong, Chong Rae Park, Chong-Su Cho pp.822-826

Synthesis of PEO-based glucose-sensitivity block copolymers and their application for preparation of superparamagnetic iron oxide nanoparticles Sangmi Lee ,Joo Hyeon Nam ,Yoo Jin Kim ,Young Jun Cho ,Nam Hyeon Kwon ,Jae Yeol Lee ,Ho-Jung Kang ,Hoong Tae Kim ,Heung Mok Park ,Sehoon Kim ,Jungahn Kim pp.827-834

Enhancement of cardiac myoblast responses onto electrospun PLCL fibrous matrices coated with polydopamine for gelatin immobilization Young Min Shin ,Hansoo Park ,Heungsoo Shin pp.835-842

Highly effective T2 MR contrast agent based on heparinized superparamagnetic iron oxide nanoparticles Dong Yun Lee pp.843-847

Preparation of chlorine e6-conjugated single-wall carbon nanotube for photodynamic therapy Dong Jin Lee ,So Young Park ,Young Taik Oh ,Nam Muk Oh ,Kyung Taek Oh ,Yu Seok Youn ,Eun Seong Lee pp.848-852

pH-dependent mode of antibacterial actions of low molecular weight water-soluble chitosan(LMWSC) against various pathogens Seong-Cheol Park ,Jae-Woon Nah ,Yoonkyung Park pp.853-860

Hyaluronidase-sensitive SPIONs for MR/optical dual imaging nanoprobes Dong-Eun Lee ,Ah Young Kim ,Gurusamy Saravanakumar ,Heebeom Koo ,Ick Chan Kwon ,Kuiwon Choi ,Jae Hyung Park ,Kwangmeyung Kim pp.861-867

참고문헌 (38건) : 자료제공( 네이버학술정보 )

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