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Background: Portulaca oleracea L. is known to have detoxification and antibacterial effects. Inflammatory responses in LPS-treated Raw264.7 cells include the secretions of NO,PGE2 and numerous cytokines. Atopic dermatitis is a chronic inflammatory skin disease. This study was performed to identify the antiinflammatory or anti-pruritic effects of Portulaca oleracea L. extract in LPS-treated Raw264.7 cells and keratinocytes and the skin of NC/Nga mice with atopic dermatitis, as well as hairless mice with pruritus. Methods: After the treatment of different concentrations for Portulaca oleracea L. extract in LPS-treated Raw264.7 cells and keratinocytes, the levels of NO, PGE2 and proinflammatory cytokines were measured in the media. Skin tissues of all Nc/Nga mice were subjected to H&E staining and toluidine blue staining. An antipruritic effect was defined as the number of scratching behaviors of the hairless SKH-1 mice treated with compound 48/80. Results: LPS- and IFN-γ-treated Raw264.7 cells decreased NO and PGE2 productions compared to non-treated Raw264.7cells. H&E or toluidine blue staining revealed that the thicknesses of the epidermis and dermis were reduced in NC/Nga mice with atopic dermatitis treated with Portulaca oleracea L. extract. However, Itching behaviors in hairless mice treated with Portulaca oleracea L. extract were not decreased compared to non-treated hairless mice. Conclusion: The results of this study suggest that Portulaca oleracea L. extract could be a new therapeutic agent for atopic dermatitis.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
식품알레르기 : 진단과 관리 안강모 pp.163-169

천식과 감염질환 : 천식이 감염질환에 미치는 임상적 영향 유광하 pp.170-174

약물유해반응의 보고 및 임상양상 조영주 pp.175-176

수도권 학령전기 소아에서 식품알레르기의 유병률 및 위험인자 정영호, 고훈, 김형영, 서주희, 권지원, 김병주, 김효빈, 이소연, 장광천, 송대진, 김우경, 심정연, 홍수종 pp.177-183

단일 대학병원 약물유해반응의 보고 및 임상양상 류성윤, 고영일, 신희영, 박승환, 류시현, 김하나, 김민석, 천승우 pp.184-191

Cefaclor 즉시형 과민반응을 나타낸 환자들의 임상적 및 면역학적 특징 남영희, 김정은, 황의경, 진현정, 신유섭, 예영민, 남동호, 박해심 pp.192-198

마치현(Portulaca oleracea L.) 추출물의 항염 및 항소양 작용 : LPS 처리로 염증을 유도한 Raw264.7세포와 각질형성세포, NC/Nga 마우스, Hairless 마우스에 대한 결과 임윤영, 김형미, 박원석, 김정환, 신홍주, 김명남, 김범준 pp.199-206

NC/Nga 마우스에서의 아토피피부염 유사 병변에 대한 Light Emitting Diode 치료 효과 임윤영, 장우선, 김형미, 김인수, 이진웅, 김명남, 김범준 pp.207-214

캐슈 섭취 후 발생한 식품알레르기 1예 김미영, 강민규, 이서영, 강성윤, 심은진, 정재우, 강혜련 pp.215-218

Levodropropizine에 의한 아나필락시스 : 증례보고 윤경애, 김상훈, 안영민 pp.219-222

플루오레세인(Fluorescein)에 의해 발생한 아나필락시스 1예 이서영, 김주영, 강민규, 김미영, 송우정, 정재우, 강혜련 pp.223-225

신종플루 예방 접종 후 천식 악화로 발생한 자발성 종격동기종 1예 양동주, 최유진, 이만, 이유미, 권선중, 손지웅, 나문준 pp.226-229

참고문헌 (36건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Immunology of the Male Reproductive System 네이버 미소장
2 Mechanisms of phagocytosis 네이버 미소장
3 Inhibition of LPS induced iNOS, COX-2 and cytokines expression by salidroside through the NF-κB inactivation in RAW 264.7 cells 네이버 미소장
4 In vitro Antiinflammatory Activity of the Essential Oil from Ligularia fischeri var. spiciformis in Murine Marcrophage Raw 264.7 Cells 소장
5 Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages 네이버 미소장
6 Choi AJ, Jee HK, Ko BS, Kim YH, Lee SJ, Kim CJ, et al. Solubilization of Arabinogalactan by extrusion from Portulaca oleracea L. and its in vitro antioxidant activity. Food Eng Prog. 2009;13:169-75. 미소장
7 Simple evaluation of the wound healing activity of a crude extract of Portulaca oleracea L. (growing in Jordan) in Mus musculus JVI-1 네이버 미소장
8 Chan K, Islama MW, Kamil M, Radhakrishnana R, Zakariaa MNM, Habibullahc M, et al. The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. sativa (Haw.) Celak J Ethnopharmacol. 2000;73:445-51. 미소장
9 Anti-inflammatory Effects of Gelidium amansii in RAW 264.7 Macrophages 소장
10 The Inhibitory Effects of Portulaca oleracea L. on HCl-ethanol Induced Gastritis in Rats 소장
11 Antioxidant properties of different cultivars of Portulaca oleracea 네이버 미소장
12 Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative damage induced by D-galactose in the brains of senescent mice 네이버 미소장
13 Effects of Portulaca Oleracea L. Extract on Lipolysis and Hormone Sensitive Lipase (HSL) Gene Expression in 3T3-L1 Adipocytes 소장
14 Anti-hypoxic activity of the ethanol extract from Portulaca oleracea in mice 네이버 미소장
15 Characterization of structures and antiviral effects of polysaccharides from Portulaca oleracea L. 네이버 미소장
16 Identification of Portulaca oleracea L. from different sources using GC–MS and FT-IR spectroscopy 네이버 미소장
17 Portulene, a new diterpene from Portulaca oleracea L. 네이버 미소장
18 A Novel Atopic Dermatitis Model Induced by Topical Application with Dermatophagoides Farinae Extract in NC/Nga Mice 네이버 미소장
19 Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. 네이버 미소장
20 Mast cell degranulation and histamine release observed in a new in vitro system. 네이버 미소장
21 The Cytokine Interleukin-33 Mediates Anaphylactic Shock 네이버 미소장
22 Reduction of tissue histamine by compound 48/80. 네이버 미소장
23 Anti-allergic effects of Artemisia iwayomogi on mast cell-mediated allergy model. 네이버 미소장
24 Experimental anxiety induced by histaminergics in mast cell-deficient and congenitally normal mice 네이버 미소장
25 Mitogen-activated protein kinases and nuclear factor-kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages. 네이버 미소장
26 Blichmann CW, Serup J. Assessment of skin moisture. Measurement of electrical conductance, capacitance and transepidermal water loss. Acta Derm Venereol. 1988;68:284-90. 미소장
27 New insights into atopic dermatitis. 네이버 미소장
28 Proinflammatory Cytokines 네이버 미소장
29 Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors 네이버 미소장
30 Cytokine disbalance in common human cancers 네이버 미소장
31 Molecular mechanisms of mouse skin tumor promotion. 네이버 미소장
32 Kim BJ, Lim YY, Kim HM, Park EJ, Kim MN, Cho SM, et al. Effect of anti-inflammation and skin hydration of AF-343 on macrophage RAW 264.7 cells and NC/Nga mice with atopic dermatitis. Kor J Med Myol. 2010;15:61-76. 미소장
33 Kim YH, Han JK, Kim YH. Effect of Kami-kanghwalsan (KKHS) on atopic dermatitis-like skin lesions induced in Nc/Nga mouse by mite antigen stimulation. J Korean Oriental Pediatrics. 2008; 22:69-93. 미소장
34 Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation 네이버 미소장
35 Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappaB pathway. 네이버 미소장
36 Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes 네이버 미소장