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Objectives : Achyranthis Bidentatae Radix (ABR) has been used for treating of many symptoms especially osteoporosis and rheumatoid arthritis. In this study, we determined the effects of water extract of ABR in RANKL (Receptor Activator for Nuclear Factor κ B Ligand)-induced osteoclast differentiation culture system.

Methods : We assayed mRNA expression levels of NFATc1, c-Fos, TRAP, OSCAR, FcRγ, DAP12 and GAPDH in bone marrow macrophages (BMMs) treated with ABR. The protein expression levels of NFATc1, c-Fos, MAPKs and β-actin in cell lysates treated with ABR were analysed by Western blotting. In addition we determined the effects of water extract of ABR on LPS-induced bone-loss mouse.

Results : Water extract of ABR showed remarkable inhibition on RANKL-treated osteoclast differentiation without cytotoxicity. ABR down-regulated the induction of c-Fos and NFATc1 by RANKL. ABR suppressed phosphorylation of JNK, p38 and I-κB. ABR rescued bone erosion by LPS induction in vivo study.

Conclusions : These results demonstrate that ABR may be a useful remedy for curing of bone-loss disease such as osteoporosis.

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HMC05의 배양 Chinese Hamster Lung 세포를 이용한 염색체이상 시험 신흥묵 pp.1-7

전탕방법에 따른 전탕액의 추출률 비교연구 : 평위산 전탕액의 Hesperidin HPLC 분석 양웅모, 정규진, 김경욱, 배현수, 장문석, 박성규 pp.9-12

夜交藤이 흰쥐 뇌와 간에서의 산화 억제에 미치는 영향 이한구, 한효상, 이영종 pp.13-21

土茯苓의 기원식물별 위암 세포 SNU-1에 대한 항암효과 비교연구 안한규, 한효상, 이영종 pp.23-31

강활추출물이 알레르기 천식 모델 생쥐에 기관지폐포세척액의 면역세포에 미치는 영향 배진현, 유지현, 길기정 pp.33-38

皂角刺 추출물의 항응혈 활성 유지현, 정봉태, 길기정 pp.39-43

山椒의 이물허용치에 대한 각국의 약전 비교연구 박수진, 김인락 pp.45-54

Collagen Ⅱ-induced Arthritis 생쥐에 대한 杜仲·續斷 배합약물의 관절염 억제 효과 이부균, 이영철, 이장천 pp.55-63

우슬의 파골세포 분화 억제와 골 흡수 억제효과 김주호, 기지예, 안지영, 박혜정, 김현주, 곽한복, 오재민, 김윤경 pp.65-74

New multi-herb mixture, HT005, induces longitudinal bone growth in male rats Mi-Yeon Kim, Marcus J. Ramirez, Donghun Lee, Dong Wook Lim, Ho Young Choi, Hocheol Kim pp.75-81

울금과 강황의 항산화 및 항염증 활성 비교연구 오혜인, 박한별, 주미선, 정선용, 오명숙 pp.83-91

참고문헌 (43건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 National Osteoporosis Foundation. America’s Bone Health. The State of Osteoporosis and Low Bone Mass in Our Nation. Washington, DC : National Osteoporosis Foundation. 2002. 미소장
2 Osteoporosis: A still increasing prevalence 네이버 미소장
3 Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. 네이버 미소장
4 Interfering with bone remodelling 네이버 미소장
5 Osteoclast differentiation and activation 네이버 미소장
6 Activation of NF-κB by RANK Requires Tumor Necrosis Factor Receptor-associated Factor (TRAF) 6 and NF-κB-inducing Kinase 네이버 미소장
7 Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts 네이버 미소장
8 Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. 네이버 미소장
9 Intermittent intravenous ibandronate injections reduce vertebral fracture risk in corticosteroid-induced osteoporosis: results from a long-term comparative study 네이버 미소장
10 Reduction of Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis Treated With RaloxifeneResults From a 3-Year Randomized Clinical Trial 네이버 미소장
11 Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. 네이버 미소장
12 Effect of Water Extract of Deer Antler in Osteoclast Differentiation 소장
13 Inhibitory effects of Stewartia koreana on osteoclast differentiation and bone resorption 네이버 미소장
14 Inhibition of osteoclast differentiation and bone resorption by sauchinone 네이버 미소장
15 Paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting ERK, p38 and NF-κB pathway 네이버 미소장
16 Juan Li, Hui Qi, Lian-Wen Qi, Ling Yi, Ping Li. Simultaneous determination of main phytoecdysones and triterpenoids in Radix Achyranthis Bidentatae by high-performance liquid chromatography with diode array-evaporative light scattering detectors and mass spectrometry. Analytica Chimica Acta. 2007 ; 596 : 264-72. 미소장
17 [The research on analgestic and anti-inflammatory action of different processed products of Achyranthes bidentata]. 네이버 미소장
18 Chen XM, Tian GY. Structural elucidation and antitumor activity of a fructan from Cyathula officinalis Kuan. Carbohydr Res. 2003 ; 338(11) : 1235-41. 미소장
19 Gao XY, Wang DW, Li FM. Determination of ecdysterone in Achyranthes Bidentata Bl and its activity promoting proliferation of osteoblast-like cells. Yao Xue Xue Bao. 2000 ; 35(11) : 868-70. 미소장
20 Rodan GA, Raisz LG, Bilezikian JP. Principles of bone biology. Pathophysiology of osteoporosis. 2002 ; 1275-89. 미소장
21 Osteoclastogenesis--current knowledge and future perspectives. 네이버 미소장
22 Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. 네이버 미소장
23 Osteoprotegerin deficiency and juvenile Paget's disease. 네이버 미소장
24 TRAF6 Is a Critical Factor for Dendritic Cell Maturation and Development 네이버 미소장
25 Osteopetrosis in mice lacking NF-κB1 and NF-κB2 네이버 미소장
26 RANK Ligand-induced Elevation of Cytosolic Ca2+ Accelerates Nuclear Translocation of Nuclear Factor κB in Osteoclasts 네이버 미소장
27 Tumor Necrosis Factor Receptor Family Member RANK Mediates Osteoclast Differentiation and Activation Induced by Osteoprotegerin Ligand 네이버 미소장
28 Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK. 네이버 미소장
29 The phosphatidylinositol 3-Kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation 네이버 미소장
30 p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function. 네이버 미소장
31 Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL). 네이버 미소장
32 Kwak HB, Lee SW, Li YJ, Kim YA, Han SY, Jhon GJ, Kim HH, Lee ZH. Inhibitory of osteoclast differentiation and bone resorption by a novel lysophosphatidylcholine derivative, SCOH. Biochemical Pharmacology. 2004 ; 67 : 1239-48. 미소장
33 Stress signals for apoptosis: ceramide and c-Jun kinase. 네이버 미소장
34 Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts 네이버 미소장
35 AP-1: a double-edged sword in tumorigenesis 네이버 미소장
36 Fos/AP‐1 proteins in bone and the immune system 네이버 미소장
37 Bone and haematopoietic defects in mice lacking c-fos. 네이버 미소장
38 Amazing multifunctionality of calcineurin and NFAT signaling in bone homeostasis 네이버 미소장
39 Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. 네이버 미소장
40 Kim Y, Sato K, Asagiri M, Morita I, Soma K, Takayanagi H. Contribution of NFATc1 to the transcriptional control of immunoreceptor OSCAR but not TREM-2 during osteoclastogenesis. J Biol Chem. 2005 ; 280 : 32905-13. 미소장
41 The Immunomodulatory Adapter Proteins DAP12 and Fc Receptor γ-Chain (FcRγ) Regulate Development of Functional Osteoclasts through the Syk Tyrosine Kinase 네이버 미소장
42 Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-alpha, IL-1, and RANKL. 네이버 미소장
43 Toll-like receptors in the induction of the innate immune response. 네이버 미소장

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