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Lead (Pb) is a ubiquitously occurring environmental heavy metal which is widely used in industry and

human life. Possibly due to a global industrial expansion, recent studies have revealed the prevalent

human exposure to Pb and increased risk of Pb toxicity. Once ingested by human, 95% of absorbed

Pb is accumulated into erythrocytes and erythrocytes are known to be a prime target for Pb toxicity.

Most of the studies were however, focused on Pb2+ whereas the effects of Pb4+, another major form

of Pb on erythrocytes are poorly understood yet. In this study, we investigated and compared the

effects of Pb4+, Pb2+ and other heavy metals on procoagulant activation of erythrocytes, an important

factor for the participation of erythrocytes in thrombotic events in an effort to address the cardiovascular

toxicity of Pb4+. Freshly isolated erythrocytes from human were incubated with Pb4+, Pb2+, Cd2+

and Ag+ and the exposure of phosphatidylserine (PS), key marker for procoagulant activation was

measured using flow cytometry. As a result, while Cd2+ and Ag+ did not affect PS exposure, Pb4+ and

Pb2+ induced significantly PS exposure in a dose-dependent manner. Of a particular note, Pb4+

induced PS exposure with a similar potency with Pb2+. PS bearing microvesicle (MV), another important

contributor to procoagulant activation was also generated by Pb4+. These PS exposure and MV

generation by Pb4+ were well in line with the shape change of erythrocyte from normal discocytes to

MV shedding echinocytes following Pb4+ treatment. Meanwhile, nonspecific hemolysis was not

observed suggesting the specificity of Pb4+-induced PS exposure and MV generation. These results

indicated that Pb4+ could induce procoagulant activation of erythrocytes through PS exposure and MV

generation, suggesting that Pb4+ exposure might ultimately lead to increased thrombotic events.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
(The)role of Nrf2 in cellular innate immune response to inflammatory injury Jiyoung Kim, Young-Joon Surh pp.159-173

Effect of lead(Ⅳ) acetate on procoagulant activity in human red blood cells Keun-Young Kim, Kyung-Min Lim, Jung-Hun Shin, Ji-Yoon Noh, Jae-Bum Ahn, Da-Hye Lee, Jin-Ho Chung pp.175-180

Cytotoxic effects on HL-60 cells of myosin light chain kinase inhibitor ML-7 alone and in combination with flavonoids Joong Won Lee, Yang Jee Kim, Young Joo Choi, Hae Dong Woo, Gye Eun Kim, Tae Kyung Ha, Young Hyun Lee, Hai Won Chung pp.181-188

Establishment of a stable cell line expressing green fluorescence protein-fused hypoxia inducible factor-1α for assessment of carcinogenicity of chemical toxicants Sung-Hye Kim, Hee-won Seo, Min-Ho Lee, Jin-Ho Chung, Byung Hoon Lee, Mi-Ock Lee pp.189-193

Increased gene expression in cultured BEAS-2B cells treated with metal oxide nanoparticles Eun-Jung Park, Kwangsik Park pp.195-201

Dose-response effects of epichlorohydrin on male reproductive function in rats Kang-Hyeon Kim, In-Sik Shin, Jeong-Hyeon Lim, Sung-Hwan Kim, Na-Hyeong Park, Changjong Moon, Sung-Ho Kim, Dong-Ho Shin, Jong-Choon Kim pp.203-207

Effects of concrete and wood building environments on pregnant dams and embryo-fetal development in rats In-Sik Shin, Sung-Hwan Kim, Jeong-Hyeon Lim, Jong-Chan Lee, Na-Hyeong Park, Dong-Ho Shin, Changjong Moon, Sung-Ho Kim, Jong-Choon Kim pp.209-216

Blood levels of IL-Iβ, IL-6, IL-8, TNF-α, and MCP-1 in pneumoconiosis patients exposed to inorganic dusts Jong Seong Lee, Jae Hoon Shin, Joung Oh Lee, Won-Jeong Lee, Joo-Hwan Hwang, Ji Hong Kim, Byung-Soon Choi pp.217-224

Micronucleus test of DHU001, a polyherbal formula, in bone marrow cells of male ICR mice Seong-Soo Roh, Hyeung-Sik Lee, Sae-Kwang Ku pp.225-230

Real-time voltammetric assay of lead ion in biological cell systems Suw Young Ly pp.231-235

Studies on the dermal and ocular irritation of prodigiosin isolated from Zooshikella rubidus Yong-Sook Kim, Jong-Myoung Choi, Jung-Hoon Yoon, Myung-Jin Choi, Md. Ahsanur Reza, Seung-Chun Park pp.237-242

Evaluation of antioxidative activity of Agrimonia pilosa-Ledeb leaves on non-lipid oxidative damage Dae-Sik Hah, Chung-Hui Kim, Euikyung Kim, Jong-Shu Kim pp.243-251

참고문헌 (25건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 The effect of lead ions on the energy metabolism of human erythrocytes in vitro. 네이버 미소장
2 Erythrocyte delta-aminolaevulic acid dehydrase activity in anaemia. 네이버 미소장
3 CDCP. (1997). Screening Young Children for Lead Poisoning: Guidance for State and Local Public Health Officials. Department of Health and Human Services, Public Health Service, Atlanta, GA. 미소장
4 Lysophosphatidic acid induces thrombogenic activity through phosphatidylserine exposure and procoagulant microvesicle generation in human erythrocytes. 네이버 미소장
5 Particle digestibility is required for induction of the phosphatidylserine recognition mechanism used by murine macrophages to phagocytose apoptotic cells. 네이버 미소장
6 Franck, P.F., Bevers, E.M., Lubin, B.H., Comfurius, P., Chiu, D.T., Op den Kamp, J.A., Zwaal, R.F., van Deenen, L.L. and Roelofsen, B. (1985). Uncoupling of the membrane skeleton from the lipid bilayer. The cause of accelerated phospholipid flip-flop leading to an enhanced procoagulant activity of sickled cells. J. Clin. Invest., 75, 183-190. 미소장
7 Effect of Lead on Erythrocyte Membranes 네이버 미소장
8 Goyer, R.A. and Clarkson, T.W. (2001) Toxic effects of metals. In: Casarett & Doull’s Toxicology, p. 829, McGraw-Hill, USA. 미소장
9 Gurer, H., Ozgunes, H., Neal, R., Spitz, D.R. and Ercal, N. (1998). Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats. Toxicology, 128, 181-189. 미소장
10 Increased procoagulant activity of red blood cells from patients with homozygous sickle cell disease and beta-thalassemia. 네이버 미소장
11 Effects of low doses of dietary lead on red blood cell production in male and female mice. 네이버 미소장
12 Ito, Y., Niiya, Y., Kurita, H., Shima, S. and Sarai, S. (1985). Serum lipid peroxide level and blood superoxide dismutase activity in workers with occupational exposure to lead. Int. Arch. Occup. Environ. Health, 56, 119-127. 미소장
13 Membrane-dependent reactions in blood coagulation: role of the vitamin K-dependent enzyme complexes. 네이버 미소장
14 Stimulation of erythrocyte phosphatidylserine exposure by lead ions. 네이버 미소장
15 Surface-dependent reactions of the vitamin K-dependent enzyme complexes. 네이버 미소장
16 Marcus, A.J. (1990). Stratton lecture 1989. Thrombosis and inflammation as multicellular processes: pathophysiologic significance of transcellular metabolism. Blood, 76, 1903-1907. 미소장
17 Calcium Stimulation of Procoagulant Activity in Human Erythrocytes 네이버 미소장
18 Free radical generation during delta-aminolevulinic acid autoxidation: induction by hemoglobin and connections with porphyrinpathies. 네이버 미소장
19 Action of lead(II) and aluminium (III) ions on iron-stimulated lipid peroxidation in liposomes, erythrocytes and rat liver microsomal fractions. 네이버 미소장
20 Lead-induced procoagulant activation of erythrocytes through phosphatidylserine exposure may lead to thrombotic diseases. 네이버 미소장
21 Lipid Peroxidation and Concentration of Glutathione in Erythrocytes from Workers Exposed to Lead 네이버 미소장
22 Platelet-erythrocyte interactions enhance alpha(IIb)beta(3) integrin receptor activation and P-selectin expression during platelet recruitment: down-regulation by aspirin ex vivo. 네이버 미소장
23 The Anaemia of Lead Poisoning: A Review 네이버 미소장
24 Membrane and lipid involvement in blood coagulation. 네이버 미소장
25 Membrane asymmetry and blood coagulation. 네이버 미소장

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