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A series of sesquiterpenes and hinokitiol-related compounds (1-15) was isolated from the essential oil of Thujopsis dolabrata Sieb. et Zucc. var. hondai Makino, and their structures were determined by combined spectroscopic analyses. The inhibitory effects of these compounds on microbial cell growth and Na^+/K^+-ATPase were evaluated in vitro. It was found that (-)-elema-1,3,11(13)-trien-12-ol (5), α,β,γ-costol (8), and chamigrenol (11) inhibit the activities of Na^+/K^+-ATPase, with IC_50 values of 11.2 ± 0.11, 12.2 ± 0.09, and 15.9 ± 0.54 μg/mL, respectively. Thujopsene (1), cedrol (9), γ-cuparenol (10), and chamigrenol (11) showed potent antibacterial activity, with MIC values in the range of 25-50 μg/mL, and β-thujaplicin (12) exhibited a broad spectrum of antibacterial and antifungal activity. These results indicate that these isolated compounds are promising candidates for the development of potent Na^+/K^+ ATPase inhibitors and antimicrobial agents.

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참고문헌 (32건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Ahn, Y. J., Lee, S. B., Okubo, T., and Kim, M., Antignawing factor of crude oil derived from ThujopsisdolabrataS. et Z. var. hondai sawdust against mice. J. Chem. Ecol., 21, 263- 271 (1995). 미소장
2 Ahn, Y. J., Lee, S. B., Lee, H. S., and Kim, G. H., Insecticidal and acaricidal activity of carvacrol and β-thujaplicine derived from Thujopsisdolabratavar. hondai sawdust. J. Chem. Ecol., 24, 81-90 (1998). 미소장
3 Topical use of hinokitiol ointment in atopic dermatitis patients 네이버 미소장
4 Inhibitory effect of beta-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes. 네이버 미소장
5 Catechol O-methyltransferase. 1. Kinetics of tropolone inhibition. 네이버 미소장
6 Dholwani, K. K., Saluja, A. K., Gupta, A. R., and Shah, D. R., A review on plant-derived natural products and their analogs with anti-tumor activity. Indian J. Pharmacol., 40, 49-58 (2008). 미소장
7 Enzell, C., The chemistry of the natural order cupressales 47. The structures and absolute configurations of widdrol and widdrol-aepoxide. Acta Chem. Scand., 16, 1552-1568 (1962). 미소장
8 Terpenes from heartwood of Juniperus chinensis 네이버 미소장
9 The central role of the brain in salt-sensitive hypertension. 네이버 미소장
10 Cytotoxic Effect of Hinokitiol and Tropolone on the Growth of Mammalian Cells and on Blastogenesis of Mouse Splenic T Cells. 네이버 미소장
11 Antimicrobial Activity and Metalloprotease Inhibition of Hinokitiol-Related Compounds, the Constituents of Thujopsis dolabrata S. and Z. hondai MAk. 네이버 미소장
12 New constituents of [formula omitted][formula omitted] 네이버 미소장
13 Salt, Na +,K +-ATPase and hypertension 네이버 미소장
14 Activity and protein expression of Na+/K+ ATPase are reduced in microvillous syncytiotrophoblast plasma membranes isolated from pregnancies complicated by intrauterine growth restriction. 네이버 미소장
15 13 C-nmr Study of Cedrol, 6-Isocedrol, and α-Cedrene 네이버 미소장
16 L'Oreal Cosmetic, K. K., Japan. KokaiTokkyoKoho, JP 81147704, (1982). 미소장
17 Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. 네이버 미소장
18 Lee, S. G., Kim, S. I., Ahn, Y. J., Kim, J. B., and Lee, B. Y., Effectiveness of carvacrol derived from Thujopsisdolabrata var. hondai sawdust against Thecodiplosisjaponensis (Diptera: Cecidomyiidae). Pestic. Sci., 49, 119-124 (1997). 미소장
19 Sesquiterpenoids from Costus Root Oil (Saussurea lappa CLARKE) 네이버 미소장
20 Biological Activity of Tropolone 네이버 미소장
21 Biological activity of beta-dolabrin, gamma-thujaplicin, and 4-acetyltropolone, hinokitiol-related compounds. 네이버 미소장
22 Essential Oil of Thujopsis dolobrata Suppresses Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice 소장
23 Isolation of (-)-4'-demethyl traxillagenin from Thujopsis dolabrata Sieb. et Zucc. var. hondai Makino 네이버 미소장
24 On the Acidic Constituents of the Essential Oil of Thujopsis dolabrata. Occurrence of α-Thujaplicin 네이버 미소장
25 Synthesis and antimicrobial activities of halogenated bis(hydroxyphenyl)methanes. 네이버 미소장
26 New sesquiterpenoids from [formula omitted] 네이버 미소장
27 Phytogrowth-Inhibitory activities of beta-dolabrin and gamma-thujaplicin, hinokitiol-related compounds and constituents of Thujopsis dolabrata Sieb. et Zucc. var hondai Makino. 네이버 미소장
28 Sakai, I. and Tamura, U., Japan. KokaiTokkyoKoho, JP 6318869, (1989). 미소장
29 SIK1 Is Part of a Cell Sodium-Sensing Network That Regulates Active Sodium Transport through a Calcium-Dependent Process 네이버 미소장
30 Antiplatelet Activity of Thujopsis dolabrata var. hondai-Derived Component Against Platelet Aggregation 소장
31 Chemotaxonomy on the leaf constituents of Thujopsis dolabrata Sieb. et Zucc.—Analysis of neutral extracts (diterpene hydrocarbon) 네이버 미소장
32 Yamaji, K., Mori, S., Akiyama, M., Kato, A., and Nakashima, T., The antifungal compound totarol of Thujopsisdolabrata var. hondai seeds selects for fungi on seedling root surfaces. J. Chem. Ecol., 33, 2254-2265 (2007). 미소장

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