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Contents

Factors to predict positive results of gonadotropin releasing hormone stimulation test in girls with suspected precosious puberty / Hyo-Kyoung Nam ; Young Jun Rhie ; Chang Sung Son ; Sang Hee Park ; Kee-Hyoung Lee 1

[요약] 1

INTRODUCTION 1

MATERIALS AND METHODS 1

Subjects 1

Methods 2

Statistics 2

Ethics statement 2

RESULTS 2

Clinical and auxological characteristics of all subjects 2

Comparison of clinical and biochemical characteristics between groups 2

The binary logistic regression analysis 3

Sensitivity and specificity of the growth velocity ratio 4

DISCUSSION 4

REFERENCES 5

초록보기

Sometimes, the clinical findings and the results of the gonadotropin-releasing hormone (GnRH) stimulation test are inconsistent in girls with early breast development and bone age advancement. We aimed to investigate the factors predicting positive results of the GnRH stimulation test in girls with suspected central precocious puberty (CPP). We reviewed the records of 574 girls who developed breast budding before the age of 8 yr and underwent the GnRH stimulation test under the age of 9 yr. Positive results of the GnRH stimulated peak luteinizing hormone (LH) level were defined as 5 IU/L and over. Girls with the initial positive results (n = 375) showed accelerated growth, advanced bone age and higher serum basal LH, follicle-stimulating hormone, and estradiol levels, compared to those with the initial negative results (n = 199). Girls with the follow-up positive results (n = 64) showed accelerated growth and advanced bone age, compared to those with the follow-up negative results. In the binary logistic regression, the growth velocity ratio was the most significant predictive factor of positive results. We suggest that the rapid growth velocity is the most useful predictive factor for positive results in the GnRH stimulation test in girls with suspected precocious puberty.

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참고문헌 (24건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Early growth acceleration in girls with idiopathic precocious puberty 네이버 미소장
2 Rosenfield RL, Cooke DW, Radovick S. Puberty and its disorders in the female: abnormal puberty. In: Sperling MA editor. Pediatric endocrinology. 3rd ed. Philadelphia: Saunders, 2008; 565-73. 미소장
3 Positive parenting and early puberty in girls: protective effects against aggressive behavior. 네이버 미소장
4 Disorders of pubertal development: precocious puberty. 네이버 미소장
5 Adult height in girls with idiopathic true precocious puberty 네이버 미소장
6 Precocious puberty and statural growth 네이버 미소장
7 A single sample subcutaneous luteinizing hormone (LH)-releasing hormone (LHRH) stimulation test for monitoring LH suppression in children with central precocious puberty receiving LHRH agonists. 네이버 미소장
8 Adequacy of a single unstimulated luteinizing hormone level to diagnose central precocious puberty in girls. 네이버 미소장
9 Moon JS, Lee SY, Nam CM, Choi JM, Choe BK, Seo JW, Oh KW, Jang MJ, Hwang SS, Yoo MH, Kim YT, Lee CG. 2007 Korean National Growth Charts: review of developmental process and an outlook. Korean J Pediatr 2008; 51: 1-25. 미소장
10 Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. 네이버 미소장
11 The timing of sexual maturation and secular trends of menarchial age in Korean adolescents 소장
12 Na JM, Lee YJ, Kim MS, Lee DY, Yeo CY, Kim CJ, Kim JD, Kim EY. Causes of Precocious Puberty : Multicenter Study in Honam Area. J Korean Soc Pediatr Endocrinol 2009; 14: 30-7. 미소장
13 Premature thelarche: identification of clinical and laboratory data for the diagnosis of precocious puberty 네이버 미소장
14 Kim TH, Coe HJ, Kim S, Lee SW, Chae HW, Kim YS, Park MJ, Chung SC, Yu EK, Kim DH, Kim HS. Clinical and endocrinologic characteristics of children referred for precocious puberty. J Korean Soc Pediatr Endocrinol 2007; 12: 119-26. 미소장
15 Girls with Premature Adrenarche Have Accelerated Early Childhood Growth 네이버 미소장
16 Pubertal maturation in girls and the relationship to anthropometric changes: Pathways through puberty 네이버 미소장
17 Precocious pubarche is associated with SGA, prematurity, weight gain, and obesity. 네이버 미소장
18 Cho WK, Ahn SA, Park SH, Hahn SH, Jung MH, Suh BK. The auxological and hormonal differences in girls with atypical thelarche and central precocious puberty. J Korean Soc Pediatr Endocrinol 2009; 14: 60-7. 미소장
19 Garibaldi L. Disroders of pubertal development. In: Behrman RE, Kliegman RM, Jenson HB, Stanton BF, editors. Nelson Textbook of Pediatrics. 18th ed. Philadelphia: Saunders, 2007: 2308-11. 미소장
20 Serum Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3 in Girls with Premature Thelarche 네이버 미소장
21 A study of anthropomorphic and biochemical characteristics in girls with central precocious puberty and thelarche variant. 네이버 미소장
22 Lee HS, Yu JE, Yi KH, Hwang JS. Clinical and biochemical factors associated with GnRH stimulation test in the idiopathic central precocious puberty and early puberty girls. J Korean Soc Pediatr Endocrinol 2008; 13: 41-9. 미소장
23 Premature thelarche: clinical and laboratorial assessment by immunochemiluminescent assay. 네이버 미소장
24 Premature Thelarche from Phenotype to Genotype 네이버 미소장

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