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초록보기

분자 마커의 선택은 집단유전학의 연구방법을 결정하는 중요한 고려사항으로, 현재까지 동식물의 집단유전학 연구에는 알로자임, RAPD, RFLP, AFLP, microsatellite, SNP, ISSR 등이 개발되어 주로 사용되고 있다. 이 중 microsatellite는 핵뿐만 아니라 엽록체, 미토콘드리아와 같은 세포소기관의 게놈상에 매우 풍부하게 존재하며, 핵에서 유래된 microsatellite는 높은 다형성을 보이는 공우성 마커로 집단 구조 및 유전적 다양성 연구에서 최근 선호된다. Microsatellite는 보통 1~6 bp의 짧은 서열이 반복된 것으로 각각의 유전자좌에 특화된 프라이머를 사용하여 증폭한다. Microsatellite는 PCR 반응으로 쉽게 유전자형을 분석할 수 있는 장점이 있으나, 종 특이적으로 개발되고 계통적으로 매우 가까운 근연종에게만 적용될 수 있는 단점이 있다. 따라서, 야생식물의 경우 microsatellite 개발에 필요한 게놈 정보가 부족하고 신규 개발비용이 많이 소요되어 적용이 쉽지 않았으나,

점차 개발비용이 낮아지고 있어, 야생식물을 대상으로 한 microsatellite 연구들이 증가하고 있는 추세이다. 따라서, 본 논문에서는 야생식물의 microsatellite를 이용한 분석 기초를 마련하고자 microsatellite 마커의 다양한 개발 및 분석 방법, 진화 모델 및 적용 분야에 대해 소개하고, 유전자형 결정시 잘못된 결론을 도출할 가능성이 높은 부분에 대한 사항들을 지적하여 야생식물의 microsatellite를 이용한 집단유전학적 분석에 도움을 주고자 하였다.

The choice of molecular markers is the first step when selecting experimental plans in the field of population genetics. The popular molecular markers in population genetic studies are mainly allozyme, RAPD, RFLP, AFLP, microsatellite, SNP and ISSR. Among these, microsatellites are frequently found in nuclear, chloroplast and mitochondrial genome, showing a high level of polymorphism and nuclear microsatellites are codominant. Thus, it is a favorable molecular marker for population structure analyses and genetic diversity studies. Microsatellites are composed of tandem repeated 1~6 base pair nucleotide motifs and can be easily amplified by PCR reactions using locus specific primers. Because microsatellites have low cross-species transferability, however, they are only applicable between phylogenetically close species. In wild plants, the lack of genomic information and the high development cost of the microsatellite obstruct the wider use of microsatellites in plant population genetics research. In this review, we introduce the basis for microsatellite markers, the development process, and analytical methods as well as evolutionary models and their applications. In addition, possible genotyping errors which lead to erroneous conclusions are discussed.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Microsatellite 개발 및 분석법에 대한 소개 윤영은, 유정남, 이병윤, 곽명해 pp.299-314

모데미풀속과 근연속들의 형태 및 분포 비교 (미나리아재비과) 손동찬, 조경진, 고성철 pp.315-323

한국산 흰명아주와 근연종의 세포분류학적 연구 정영재, 김무열, 이병순 pp.324-328

A reappraisal of the Acer wilsonii complex and related species in China Hyun Joo Eom, Piet C. de Jong, Chin-Sung Chang pp.329-337

ITS와 psbA-trnH 염기서열에 의한 한국산 메꽃속(Calystegia R.Br.)의 분류학적 연구 김상준, 박선주 pp.338-344

큰개현삼과 근연분류군의 분류학적 재검토 장현도, 김태훈, 오병운 pp.345-352

엽록체 DNA 및 핵 DNA RNApol2_i23에 근거한 둥굴레복합체(Ruscaceae)의 계통 연구 박정미, 정경숙, 오병운, 장창기 pp.353-360

푸른몽울풀(쐐기풀과) : 국내 미기록 식물 김진석, 정재민, 이웅, 박재홍 pp.361-364

A new hybrid species of PulsatillaRanunculaceae : P. x yanbianensis H.Z. Lv Hui-Zi Lv, Soonku So, Muyeol Kim pp.365-369

무제치늪 식물상의 다양성 박성준, 안보람, 장순영, 박선주 pp.370-382

강원도 남동부 지역(동해시, 삼척시)의 식물상 한준수, 천경식, 김경아, 정희진, 유기억 pp.383-397

소백산 국립공원의 관속식물상 장창석, 양선규, 박민수, 김기홍, 서상원, 오병운 pp.398-414

청태산 지역(강원도 평창군)의 식물상 지성진, 정수영, 장진, 장정원, 이철호, 양종철, 박명순, 정규영 pp.415-428

임자도 지역의 식물상 홍행화, 손현덕, 인석영, 임형탁 pp.429-439

참고문헌 (121건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 The clonal structure of Quercus geminata revealed by conserved microsatellite loci. 네이버 미소장
2 Length polymorphisms of simple sequence repeat DNA in soybean. 네이버 미소장
3 Asif, M., Mehboob-ur-Rahman, J. I. Mirza and Y. Zafar. 2008. High resolution metaphor agarose gel electrophoresis for genotyping with microsatellite markers. Pak. J. Agri. Sci. 45: 75-79. 미소장
4 Baek, H. -J., M. -S. Yoon, H. -H. Kim, J. Lee, K. -L. Park, Y. -H. Cho and W. -Y. Choi. 2004. Diversity and relationships among Korean barley (Hordeum vulgare L.) germplasm by microsatellite. Korean J. Breed. 36: 249-259. 미소장
5 Baruah, A., V. Naik, P. S. Hendre, R. Rajkumar, P. Rajendrakumar and R. K. Aggarwal. 2003. Isolation and characterization of nine microsatellite markers from Coffea arabica L., showing wide cross-species amplifications. Mol. Ecol. Notes. 3: 647-650. 미소장
6 Fast and sensitive silver staining of DNA in polyacrylamide gels 네이버 미소장
7 Two modes of germline instability at human minisatellite MS1 (locus D1S7): complex rearrangements and paradoxical hyperdeletion. 네이버 미소장
8 Mutation rate in human microsatellites: influence of the structure and length of the tandem repeat. 네이버 미소장
9 Modulation of non-templated nucleotide addition by Taq DNA polymerase: primer modifications that facilitate genotyping. 네이버 미소장
10 Butler, J. M. 2005. Forensic DNA typing: biology, technology, and genetics of STR markers (2nd Edition). Elsevier Academic Press, New York. Pp. 331-333. 미소장
11 Dinucleotide Repeats in the Drosophila and Human Genomes Have Complex, Length-Dependent Mutation Processes 네이버 미소장
12 Chabane, K., G. A. Ablett, G. M. Cordeiro, J. Valkoun and R. J. Henry. 2005. EST versus genomic derived microsatellite markers for genotyping wild and cultivated barley. Genet. Resour. Crop. Evol. 52: 903-909. 미소장
13 Cho, Y. -I., J. -H. Park, C. -W. Lee, W. -H. Ra, J. -W. Chung, J. -R. Lee, K. -H. Ma, S. -Y. Lee, K. -S. Lee, M. -C. Lee and Y. -J Park. 2011. Evaluation of the genetic diversity and population structure of sesame (Sesamum indicum L.) using microsatellite markers. Genes & Genomics 33: 2187-2195. 미소장
14 Choi, H. S., Y. Y. Kim, K. N. Hong, Y. P. Hong and J. O. Hyun. 2005. Genetic structure of a population of Quercus acutissima in Korea revealed by microsatellite marker. Korean J. Genetics. 27: 267-271. 미소장
15 Genetic structure of northwestern Spanish brown trout (Salmo trutta L.) populations, differences between microsatellite and allozyme loci. 네이버 미소장
16 Microsatellite null alleles in parentage analysis 네이버 미소장
17 Geographic distribution of genetic variation among native and introduced populations of Chinese tallow tree, Triadica sebifera (Euphorbiaceae). 네이버 미소장
18 Automated sizing of fluorescent-labeled simple sequence repeat (SSR) markers to assay genetic variation in soybean 네이버 미소장
19 A comparative genetic linkage map of eggplant (Solanum melongena) and its implications for genome evolution in the solanaceae. 네이버 미소장
20 Microsatellite mutations in the germline: implications for evolutionary inference. 네이버 미소장
21 Ellegren, H. 2004. Microsatellites: simple sequences with complex evolution. Nat. Rev. Genet. 5: 435-445. 미소장
22 Microsatellite genetic distances with range constraints: analytic description and problems of estimation. 네이버 미소장
23 Understanding the effects of isolation on seed and pollen flow, spatial genetic structure and effective population size of the dioecious tropical tree species Myracrodruon urundeuva 네이버 미소장
24 Gao, L., J. Tang, H. Li and J. Jia. 2003. Analysis of microsatellites in major crops assessed by computational and experimental approaches. Mol. Breed. 12: 245-261. 미소장
25 Microsatellite allele frequencies in humans and chimpanzees, with implications for constraints on allele size. 네이버 미소장
26 Genetic mapping of a new set of microsatellite markers in a reference common bean (Phaseolus vulgaris) population BAT93 x Jalo EEP558. 네이버 미소장
27 Origin(S) of the Diploid Hybrid Species Helianthus deserticola (Asteraceae) 네이버 미소장
28 Gupta, P. K., H. S. Balyan, P. C. Sharma and B. Ramesh. 1996. Microsatellites in plants: a new class of molecular markers. Curr. Sci. 70: 45-54. 미소장
29 A study of the origin of ‘shadow bands’ seen when typing dinucleotide repeat polymorphisms by the PCR 네이버 미소장
30 Glycerol-enhanced mini-polyacrylamide gel electrophoresis for the separation of differentially expressed DNA fragments in cDNA representational difference analysis. 네이버 미소장
31 The Impact of Pollination Syndrome and Habitat on Gene Flow: A Comparative Study of Two Streptocarpus (Gesneriaceae) Species 네이버 미소장
32 Jarne, P. and P. J. L. Lagoda. 1996. Microsatellites, from molecules to populations and back. Trends Ecol. Evol. 11: 424-429. 미소장
33 Microsatellite markers: an overview of the recent progress in plants 네이버 미소장
34 Karp, A., P. G. Isaac and D. S. Ingram. 1998. Molecular tools for screening biodiversity: plants and animals. Chapman and Hall, London. 미소장
35 Kim, H. S., K. G. Park, S. B. Baek, S. J. Suh and J. H. Nam. 2002. Genetic diversity of barley cultivars as revealed by SSR markers. Korean J. Crop. Sci. 47: 379-383. 미소장
36 Kim, J. and K. W. Chung. 2007. Isolation of new microsatellite-containing sequences in Acanthopanax senticosus. J. Plant Biol. 50: 557-561. 미소장
37 Identification of New Microsatellite Markers in Panax ginseng 소장
38 Measures of Variation at DNA Repeat Loci under a General Stepwise Mutation Model 네이버 미소장
39 THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION. 네이버 미소장
40 Stepwise Mutation Model and Distribution of Allelic Frequencies in a Finite Population 네이버 미소장
41 Development of a Genomic Microsatellite Library in Perennial Ryegrass (Lolium perenne) and its Use in Trait Mapping 네이버 미소장
42 Genome Evolution among Cruciferous Plants: A Lecture from the Comparison of the Genetic Maps of Three Diploid Species: Capsella rubella, Arabidopsis lyrata subsp. petraea, and A. thaliana 네이버 미소장
43 Microsatellite genotyping of post-PCR fluorescently labeled markers. 네이버 미소장
44 Shaping of Genetic Structure along Pleistocene and Modern River Systems in the Hydrochorous Riparian Azalea, Rhododendron ripense (Ericaceae) 네이버 미소장
45 Influences of landscape and pollinators on population genetic structure: Examples from three Penstemon (Plantaginaceae) species in the Great Basin 네이버 미소장
46 The Putative Mesoamerican Domestication Center of Phaseolus vulgaris Is Located in the Lerma-Santiago Basin of Mexico 네이버 미소장
47 Kwon, S. J., S. N. Ahn, J. P. Suh, H. C. Hong, Y. K. Kim, H. G. Hwang, H. P. Moon and H. C. Choi. 2000. Genetic diversity of Korean native rice varieties. Korean J. Breed. 32: 186-193. 미소장
48 Kwon, Y. -S., J. -H. Hong and K. -J. Choi. 2011. Genetic diversity of Korean barley (Hordeum vulgare L.) varieties using microsatellite markers. Kor. J. Breed. Sci. 43: 243-250. 미소장
49 Use of SSR Markers to Complement Tests of Distinctiveness,Uniformity, and Stability (DUS) of Pepper (Capsicum annuum L.) Varieties 소장
50 Assessment of Genetic Variation among Commercial Tomato (Solanum lycopersicum L.) Varieties Using SSR Markers and Morphological Characteristics 소장
51 Informative SSR markers for commercial variety discrimination in watermelon (Citrullus lanatus) 소장
52 Comparative genome mapping in Brassica. 네이버 미소장
53 Isolation and characterization of 10 microsatellite loci from Korean Leontopodium japonicum (Asteraceae). 네이버 미소장
54 Expressed Sequence Tag Analysis of Antarctic Hairgrass Deschampsia antarctica from King George Island, Antarctica 소장
55 Isolation and Characterization of 13 Microsatellite Loci from Korean Quercus acuta (Fagaceae) 소장
56 Lee, J. K. and N. -S. Kim. 2007. Genetic diversity and relationships of cultivated and weedy types of Perilla frutescens collected from East Asia revealed by microsatellite marker. Korean J. Breed. Sci. 39: 491-499. 미소장
57 Genetic variation in populations of Populus davidiana Dode based on microsatellite marker analysis 소장
58 How general are positive relationships between plant population size, fitness and genetic variation? 네이버 미소장
59 Li, G., S. -W. Kwon, Y. M. Choi and Y. -J. Park. 2011. Genetic diversity analysis of mungbean accessions from east and central Asia using SSR markers. Korean J. Intl. Agri. 23: 185-191. 미소장
60 Analysis of expressed sequence tags from Prunus mume flower and fruit and development of simple sequence repeat markers 네이버 미소장
61 An expressed sequence tag (EST) library from developing fruits of an Hawaiian endemic mint (Stenogyne rugosa, Lamiaceae): characterization and microsatellite markers 네이버 미소장
62 Ma, K. -H., A. Dixit, Y. -C. Kim, D. -Y. Lee, T. -S. Kim, E. -G. Cho and Y. -J. Park. 2007. Development and characterization of new microsatellite markers for ginseng (Panax ginseng C. A. Meyer). Conserv. Genet. 8: 1507-1509. 미소장
63 Substrate nucleotide-determined non-templated addition of adenine by Taq DNA polymerase: implications for PCR-based genotyping and cloning. 네이버 미소장
64 Clonal diversity, spatial dynamics, and small genetic population size in the rare sunflower, Helianthus verticillatus 네이버 미소장
65 Novel algorithm for automated genotyping of microsatellites 네이버 미소장
66 A Single Domestication for Maize Shown by Multilocus Microsatellite Genotyping 네이버 미소장
67 Metzker, M. L. 2010. Sequencing technologies - the next generation. Genetics 11: 31-46. 미소장
68 Moore, G., K. M. Devos, Z. Wang and M. D. Gale. 1995. Cereal genome evolution. Grasses, line up and form a circle. Curr. Biol. 5: 737-739. 미소장
69 PCR-amplified microsatellites as markers in plant genetics. 네이버 미소장
70 VMD: Viral Microsatellite Database A Comprehensive Resource for All Viral Microsatellites 네이버 미소장
71 The determination of the sequences present in the shadow bands of a dinucleotide repeat PCR. 네이버 미소장
72 Constraints on allele size at microsatellite loci: implications for genetic differentiation. 네이버 미소장
73 Chloroplast microsatellites: measures of genetic diversity and the effect of homoplasy 네이버 미소장
74 Pollen Movement in a Natural Population of Arisaema serratum (Araceae), a Plant with a Pitfall-Trap Flower Pollination System 네이버 미소장
75 Nunome, T., S. Negoro, K. Miyatake, H. Yamaguchi and H. Fukuoka. 2006. A protocol for the construction of microsatellite enriched genomic library. Plant Mol. Biol. Rep. 24: 305-312. 미소장
76 Comparison of different nuclear DNA markers for estimating intraspecific genetic diversity in plants 네이버 미소장
77 Somatic Mutations at Microsatellite Loci in Western Redcedar (Thuja plicata: Cupressaceae) 네이버 미소장
78 A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. 네이버 미소장
79 Park, S. W., Y. S. Hyun and K. W. Chung. 2009. Genetic polymorphism of microsatellite markers in Panax ginseng C.A. Meyer. J. Ginseng Res. 33: 199-205. 미소장
80 What Molecules Can Tell Us about Populations: Choosing and Using a Molecular Marker 네이버 미소장
81 Cross-species amplification of soybean (Glycine max) simple sequence repeats (SSRs) within the genus and other legume genera: implications for the transferability of SSRs in plants. 네이버 미소장
82 The Origin of Species of Acer (Sapindaceae) Endemic to Ullung Island, Korea 네이버 미소장
83 Microsatellite Behavior with Range Constraints: Parameter Estimation and Improved Distances for Use in Phylogenetic Reconstruction 네이버 미소장
84 Cross-Species Amplification of Cassava (Manihot esculenta) (Euphorbiaceae) Microsatellites: Allelic Polymorphism and Degree of Relationship 네이버 미소장
85 Simple sequence repeats as useful resources to study transcribed genes of cotton 네이버 미소장
86 Lineage admixture during postglacial range expansion is responsible for the increased gene diversity of Kalopanax septemlobus in a recently colonised territory 네이버 미소장
87 Schlötterer, C. 2000. Evolutionary dynamics of microsatellite DNA. Chromosoma 109: 365-371. 미소장
88 Schötter, C. 2004. The evolution of molecular markers - just a matter of fashion? Nat. Rev. Genet. 5: 63-69. 미소장
89 Slippage synthesis of simple sequence DNA. 네이버 미소장
90 Schuelke, M. 2000. An economic method for the fluorescent labeling of PCR fragments. Nat. Biotechnol. 18: 233-234. 미소장
91 Schug, M. D., T. F. C. Mackay and C. F. Aquadro. 1997. Low mutation rates of microsatellite loci in Drosophila melanogaster. Nat. Genet. 15: 99-102. 미소장
92 Analysis of SSRs derived from grape ESTs 네이버 미소장
93 Development of SSR and gene-targeted markers for construction of a framework linkage map of Catharanthus roseus 네이버 미소장
94 VNTR allele frequency distributions under the stepwise mutation model: a computer simulation approach. 네이버 미소장
95 Development of specific primers for cpSSR analysis in caper, olive and grapevine using consensus chloroplast primer pairs 네이버 미소장
96 Comparative DNA sequence analysis of wheat and rice genomes. 네이버 미소장
97 Bayesian estimation of range for microsatellite loci. 네이버 미소장
98 Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. 네이버 미소장
99 Sunnucks, P. 2000. Efficient genetic markers for population biology. Trends Ecol. Evol. 15: 199-203. 미소장
100 Genetic consequences of anagenetic speciation in Acer okamotoanum (Sapindaceae) on Ullung Island, Korea 네이버 미소장
101 High density molecular linkage maps of the tomato and potato genomes. 네이버 미소장
102 Conservation of Gene Repertoire but not Gene Order in Pepper and Tomato 네이버 미소장
103 Tehrani, M. S., M. M. Mardi, J. Sahebi, P. Catalan and A. Diaz -Perez. 2009. Genetic diversity and structure among Iranian tall fescue populations based on genomic-SSR and EST-SSR marker analysis. Plant. Syst. Evol. 282: 57-70. 미소장
104 Thiel, T., W. Michalek, R. K. Varshney and A, Graner. 2003. Exploiting EST databases for the development of cDNA derived microsatellite markers in barley (HordeumvulgareL.) Theor. Appl. Genet. 106: 411-422. 미소장
105 Direct Estimation of Mutation Rate for 10 Microsatellite Loci in Durum Wheat, Triticum turgidum (L.) Thell. ssp durum desf 네이버 미소장
106 Allele frequencies at microsatellite loci: the stepwise mutation model revisited. 네이버 미소장
107 Genic microsatellite markers in plants: features and applications 네이버 미소장
108 Rate and Pattern of Mutation at Microsatellite Loci in Maize 네이버 미소장
109 A clustering method for repeat analysis in DNA sequences. 네이버 미소장
110 A Low‐Cost, High‐Throughput Polyacrylamide Gel Electrophoresis System for Genotyping with Microsatellite DNA Markers 네이버 미소장
111 Wang, M. L., N. A. Barkley and T. M. Jenkins. 2009. Microsatellite markers in plants and insects. Part I: applications of biotechnology. Genes, Genomes and Genomics 3: 54-67. 미소장
112 Mining online genomic resources in Anolis carolinensis facilitates rapid and inexpensive development of cross-species microsatellite markers for the Anolis lizard genus. 네이버 미소장
113 The effect of temperature and oligonucleotide primer length on the specificity and efficiency of amplification by the polymerase chain reaction. 네이버 미소장
114 Abundance, polymorphism and genetic mapping of microsatellites in rice. 네이버 미소장
115 Fast and cost-effective mining of microsatellite markers using NGS technology: an example of a Korean water deer Hydropotes inermis argyropus. 네이버 미소장
116 Strategies for microsatellite isolation: a review 네이버 미소장
117 Zeng, L., T. -R. Kwon, X. Liu, C. Wilson, C. M. Grieve and G. B. Gregorio. 2004. Genetic diversity analyzed by microsatellite markers among rice (Oryza sativa L.) genotypes with different adaptations to saline soils. Plant Sci. 166: 1275-1285. 미소장
118 Zhao, X. and G. Kochert. 1993. Phylogenetic distribution and genetic mapping of a (GGC)n microsatellite from rice (Oryza sativa L.). Plant Mol. Biol. 21: 607-614. 미소장
119 A new genetic distance with application to constrained variation at microsatellite loci. 네이버 미소장
120 Human Population Expansion and Microsatellite Variation 네이버 미소장
121 Bridging Model and Crop Legumes through Comparative Genomics 네이버 미소장

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