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Endothelial progenitor cells (EPC) are a population of cells that circulate in the blood stream. They play a role in angiogenesis and, therefore, can be prognostic markers of vascular repair. Ginsenoside Rg3 prevents endothelial cell apoptosis through the inhibition of the mitochondrial caspase pathway. It also affects estrogen activity, which reduces EPC senescence. Sun ginseng (SG),which is heat-processed ginseng, has a high content of ginsenosides. The purpose of this study was to investigate the protective effects of SG on senescence-associated apoptosis in EPCs. In order to isolate EPCs, mononuclear cells of human blood buffy coats were cultured and characterized by their uptake of acetylated low-density lipoprotein (acLDL) and their binding of Ulex europaeus agglutinin I (ulex-lectin). Flow cytometry with annexin-V staining was performed in order to assess early and late apoptosis.

Senescence was determined by β-galactosidase (β-gal) staining. Staining with 4′-6-Diamidino-2-phenylindole verifi ed that most adherent cells (93±2.7%) were acLDL-positive and ulex-lectin-positive. The percentage of β-gal-positive EPCs was decreased from 93.8±2.0% to 62.5±3.6% by SG treatment. A fl uorescence-activated cell sorter (FACS) analysis showed that 4.9% of EPCs were late apoptotic in controls. Sun ginseng decreased the apoptotic cell population by 39% in the late stage of apoptosis from control baseline levels. In conclusion, these results show antisenescent and antiapoptotic effects of SG in human-derived EPCs, indicating that SG can enhance EPC-mediated repair mechanisms.

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기사명 저자명 페이지 원문 목차
Chemical diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng Dong-Hyun Kim pp.1-15

Cardiovascular diseases and Panax ginseng : a review on molecular mechanisms and medical applications Jong-Hoon Kim pp.16-26

Ginseng and diabetes : the evidences from in vitro, animal and human studies Hai-Dan Yuan, Jung Tae Kim, Sung Hoon Kim, Sung Hyun Chung pp.27-39

Total saponin from Korean red ginseng inhibits thromboxane A₂production associated microsomal enzyme activity in platelets Dong-Ha Lee, Hyun-Jeong Cho, Hye-Yeon Kang, Man Hee Rhee, Hwa-Jin Park pp.40-46

GABA_A_ receptor- and non-NMDA glutamate receptor-mediated actions of Korean red ginseng extract on the gonadotropin releasing hormone neurons Dong Hyu Cho, Janardhan Prasad Bhattarai, Seong Kyu Han pp.47-54

Effects of ginsenoside metabolites on GABA_A_ receptor-mediated ion currents Byung-Hwan Lee, Sun-Hye Choi, Tae-Joon Shin, Sung-Hee Hwang, Jiyeon Kang, Hyeon-Joong Kim, Byung-Ju Kim, Seung-Yeol Nah pp.55-60

Processed Panax ginseng, sun ginseng increases type I collagen by regulating MMP-1 and TIMP-1 expression in human dermal fibroblasts Kyu Choon Song, Tong-Shin Chang, Hyejin Lee, Jinhee Kim, Jeong Hill Park, Gwi Seo Hwang pp.61-67

Protective effect of processed Panax ginseng, sun ginseng on UVB-irradiated human skin keratinocyte and human dermal fibroblast Hyejin Lee, Joo Yeop Lee, Kyu Choon Song, Jinhee Kim, Jeong Hill Park, Kwang-Hoon Chun, Gwi Seo Hwang pp.68-77

Sun ginseng protects endothelial progenitor cells from senescence associated apoptosis Wooseok Im, Jin-Young Chung, Jaejun Bhan, Jiyeon Lim, Soon-Tae Lee, Kon Chu, Manho Kim pp.78-85

Anti-cancer effect of ginsenoside F₂against glioblastoma multiforme in xenograft model in SD rats Ji Yon Shin, Jung Min Lee, Heon Sub Shin, Sang Yong Park, Jung Eun Yang, Somi Kim Cho, Tae-Hoo Yi pp.86-92

Comparative study of white and steamed black Panax ginseng, P. quinquefolium, and P. notoginseng on cholinesterase inhibitory and antioxidative activity Mi Ra Lee, Beom Sik Yun, Chang Keun Sung pp.93-101

Changes in the contents of prosapogenin in the red ginseng(Panax ginseng) depending on steaming batches Sun A Lee, Hee Kyung Jo, Byung Ok Im, Sungun Kim, Wan Kyun Whang, Sung Kwon Ko pp.102-106

Fungal endophytes from three cultivars of Panax ginseng Meyer cultivated in Korea Sang Un Park, Hyoun-Sub Lim, Kee-Choon Park, Young-Hwan Park, Hanhong Bae pp.107-113

참고문헌 (54건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. 네이버 미소장
2 Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). 네이버 미소장
3 Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. 네이버 미소장
4 Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. 네이버 미소장
5 Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice. 네이버 미소장
6 Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. 네이버 미소장
7 Fadini, G. P., Miorin, M., Facco, M., Bonamico, S., Baesso, I., Grego, F., Menegolo, M., de Kreutzenberg, S. V., Tiengo, A., Agostini, C. and Avogaro, A., (2005), "Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus", J Am Coll Cardiol ,45,pp.1449-1457. 미소장
8 Reduced circulating angiogenic cells in Alzheimer disease. 네이버 미소장
9 Lee, S. T., Chu, K., Jung, K. H., Jeon, D., Bahn, J. J., Kim, J. H., Kun Lee, S., Kim, M. and Roh, J. K., (2010), "Dysfunctional characteristics of circulating angiogenic cells in Alzheimer’s disease", J Alzheimers Dis ,19,pp.1231- 1240. 미소장
10 Ginsenoside-Rg5 Suppresses Cyclin E-Dependent Protein Kinase Activity via Up-Regulating p21^C^i^p^/^W^A^F^1 and Down-Regulating Cyclin E in SK-HEP-1 Cells 네이버 미소장
11 Anti-proliferative effect of ginseng saponins on human prostate cancer cell line 네이버 미소장
12 Xu, T. M., Xin, Y., Cui, M. H., Jiang, X. and Gu, L. P., (2007), "Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer", Chin Med J (Engl) ,120,pp.584-588. 미소장
13 Yoo, J. H., Kwon, H. C., Kim, Y. J., Park, J. H. and Yang, H. O., KG-135 enriched with selected ginsenosides inhibits the proliferation of human prostate cancer cells in culture and inhibits xenograft growth in athymic mice, Cancer Lett;289:99-110. 미소장
14 Mitochondrial medicine - a key to solve pathophysiology of xxi century diseases. 네이버 미소장
15 Cell death in the nervous system 네이버 미소장
16 Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease. 네이버 미소장
17 Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. 네이버 미소장
18 Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. 네이버 미소장
19 Yoon, C. H., Hur, J., Park, K. W., Kim, J. H., Lee, C. S., Oh, I. Y., Kim, T. Y., Cho, H. J., Kang, H. J., Chae, I. H., Yang, H. K., Oh, B. H., Park, Y. B. and Kim, H. S., (2005), "Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases", Circulation ,112,pp.1618- 1627. 미소장
20 Peralta, E. A., Murphy, L. L., Minnis, J., Louis, S. and Dunnington, G. L., (2009), "American Ginseng inhibits induced COX-2 and NFKB activation in breast cancer cells", J Surg Res ,157,pp.261-267. 미소장
21 Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng 네이버 미소장
22 Is beta-galactosidase staining a marker of senescence in vitro and in vivo? 네이버 미소장
23 Chu, K., Jung, K. H., Lee, S. T., Park, H. K., Sinn, D. I., Kim, J. M., Kim, D. H., Kim, J. H., Kim, S. J., Song, E. C., Kim, M., Lee, S. K. and Roh, J. K., (2008), "Circulating endothelial progenitor cells as a new marker of endothelial dysfunction or repair in acute stroke", Stroke ,39,pp.1441- 1447. 미소장
24 Transplantation of ex vivo Expanded Endothelial Progenitor Cells for Therapeutic Neovascularization 네이버 미소장
25 Different fibrillar Aβ 1–42 concentrations induce adult hippocampal neurons to reenter various phases of the cell cycle 네이버 미소장
26 Acetyl‐L‐carnitine‐induced up‐regulation of heat shock proteins protects cortical neurons against amyloid‐beta peptide 1–42‐mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease 네이버 미소장
27 Li, J., Wang, G., Liu, J., Zhou, L., Dong, M., Wang, R., Li, X., Li, X., Lin, C. and Niu, Y., Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo, Eur J Pharmacol;649:195-201. 미소장
28 Inhibitors beta-amyloid-induced toxicity by modulating the Akt signaling pathway. 네이버 미소장
29 Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease 네이버 미소장
30 Junyent, F., Alvira, D., Yeste-Velasco, M., de la Torre, A. V., Beas-Zarate, C., Sureda, F. X., Folch, J., Pallas, M., Camins, A. and Verdaguer, E., Prosurvival role of JAK/ STAT and Akt signaling pathways in MPP+-induced apoptosis in neurons, Neurochem Int;57:774-782. 미소장
31 Neuronal Life-and-Death Signaling, Apoptosis, and Neurodegenerative Disorders 네이버 미소장
32 Apoptosis in neurodegenerative disorders 네이버 미소장
33 Panax ginseng ginsenoside-Rg 2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia 네이버 미소장
34 Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. 네이버 미소장
35 A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V 네이버 미소장
36 Steaming of ginseng at high temperature enhances biological activity. 네이버 미소장
37 Imanishi, T., Hano, T. and Nishio, I., (2005), "Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity", J Hypertens ,23,pp.1699- 1706. 미소장
38 A Biomarker that Identifies Senescent Human Cells in Culture and in Aging Skin in vivo 네이버 미소장
39 Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. 네이버 미소장
40 Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16 INK4a 네이버 미소장
41 Measurement of precuneal and hippocampal volumes using magnetic resonance volumetry in Alzheimer's disease 소장
42 Topographical disorientation in mild cognitive impairment : a voxel-based morphometry study 소장
43 Intracellular Mechanisms of Amyloid Accumulation and Pathogenesis in Alzheimer's Disease 네이버 미소장
44 Mechanisms of amyloid plaque pathogenesis 네이버 미소장
45 Brenner, S. R., Roh, J. K., Lee, S. T., Chu, K., Jung, K. H., Lee, S. K. and Kim, M., Reduced circulating angiogenic cells in Alzheimer disease, Neurology;74:346; author reply 346-347. 미소장
46 Lee, S. T., Chu, K., Jung, K. H., Jeon, D., Bahn, J. J., Kim, J. H., Kun Lee, S., Kim, M. and Roh, J. K., Dysfunctional characteristics of circulating angiogenic cells in Alzheimer’s disease, J Alzheimers Dis;19:1231-1240. 미소장
47 Donnini, S., Solito, R., Cetti, E., Corti, F., Giachetti, A., Carra, S., Beltrame, M., Cotelli, F. and Ziche, M., Abeta peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis, Faseb J;24:2385-2395. 미소장
48 Vascular cell senescence and vascular aging 네이버 미소장
49 Zlokovic, B. V., (2005), "Neurovascular mechanisms of Alzheimer’s neurodegeneration", Trends Neurosci ,28,pp.202- 208. 미소장
50 Endothelial progenitor cells: characterization and role in vascular biology. 네이버 미소장
51 An open‐label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer’s disease 네이버 미소장
52 Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. 네이버 미소장
53 Oncostatin M, an interleukin-6 family cytokine, upregulates matrix metalloproteinase-9 through the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cultured smooth muscle cells. 네이버 미소장
54 Stroke 네이버 미소장

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