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The glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. Despite combination treatments of radiation and chemotherapy, the survival periods are very short. Therefore, this study was conducted to assess the potential of ginsenoside F2 (F2) to treat GBM. In in vitro experiments with glioblastoma cells U373MG, F2 showed the cytotoxic effect with IC50 of 50 μg/mL through apoptosis, confi rmed by DNA condensation and fragmentation. The cell population of cell cycle sub-G1as indicative of apoptosis was also increased. In xenograft model in SD rats, F2 at dosage of 35 mg/kg weight was intravenously injected every two days. This reduced the tumor growth in magnetic resonance imaging images. The immunohistochemistry revealed that the anticancer activity might be mediated through inhibition of proliferation judged by Ki67 and apoptosis induced by activation of caspase-3 and -8. And the lowered expression of CD31 showed the reduction in blood vessel densities. The expression of matrix metalloproteinase-9 for invasion of cancer was also inhibited. The cell populations with cancer stem cell markers of CD133 and nestin were reduced. The results of this study suggested that F2 could be a new potential chemotherapeutic drug for GBM treatment by inhibiting the growth and invasion of cancer.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Chemical diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng Dong-Hyun Kim pp.1-15

Cardiovascular diseases and Panax ginseng : a review on molecular mechanisms and medical applications Jong-Hoon Kim pp.16-26

Ginseng and diabetes : the evidences from in vitro, animal and human studies Hai-Dan Yuan, Jung Tae Kim, Sung Hoon Kim, Sung Hyun Chung pp.27-39

Total saponin from Korean red ginseng inhibits thromboxane A₂production associated microsomal enzyme activity in platelets Dong-Ha Lee, Hyun-Jeong Cho, Hye-Yeon Kang, Man Hee Rhee, Hwa-Jin Park pp.40-46

GABA_A_ receptor- and non-NMDA glutamate receptor-mediated actions of Korean red ginseng extract on the gonadotropin releasing hormone neurons Dong Hyu Cho, Janardhan Prasad Bhattarai, Seong Kyu Han pp.47-54

Effects of ginsenoside metabolites on GABA_A_ receptor-mediated ion currents Byung-Hwan Lee, Sun-Hye Choi, Tae-Joon Shin, Sung-Hee Hwang, Jiyeon Kang, Hyeon-Joong Kim, Byung-Ju Kim, Seung-Yeol Nah pp.55-60

Processed Panax ginseng, sun ginseng increases type I collagen by regulating MMP-1 and TIMP-1 expression in human dermal fibroblasts Kyu Choon Song, Tong-Shin Chang, Hyejin Lee, Jinhee Kim, Jeong Hill Park, Gwi Seo Hwang pp.61-67

Protective effect of processed Panax ginseng, sun ginseng on UVB-irradiated human skin keratinocyte and human dermal fibroblast Hyejin Lee, Joo Yeop Lee, Kyu Choon Song, Jinhee Kim, Jeong Hill Park, Kwang-Hoon Chun, Gwi Seo Hwang pp.68-77

Sun ginseng protects endothelial progenitor cells from senescence associated apoptosis Wooseok Im, Jin-Young Chung, Jaejun Bhan, Jiyeon Lim, Soon-Tae Lee, Kon Chu, Manho Kim pp.78-85

Anti-cancer effect of ginsenoside F₂against glioblastoma multiforme in xenograft model in SD rats Ji Yon Shin, Jung Min Lee, Heon Sub Shin, Sang Yong Park, Jung Eun Yang, Somi Kim Cho, Tae-Hoo Yi pp.86-92

Comparative study of white and steamed black Panax ginseng, P. quinquefolium, and P. notoginseng on cholinesterase inhibitory and antioxidative activity Mi Ra Lee, Beom Sik Yun, Chang Keun Sung pp.93-101

Changes in the contents of prosapogenin in the red ginseng(Panax ginseng) depending on steaming batches Sun A Lee, Hee Kyung Jo, Byung Ok Im, Sungun Kim, Wan Kyun Whang, Sung Kwon Ko pp.102-106

Fungal endophytes from three cultivars of Panax ginseng Meyer cultivated in Korea Sang Un Park, Hyoun-Sub Lim, Kee-Choon Park, Young-Hwan Park, Hanhong Bae pp.107-113

참고문헌 (17건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Malignant gliomas in adults. 네이버 미소장
2 Diffuse glioma growth: a guerilla war. 네이버 미소장
3 Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis. 네이버 미소장
4 Potential therapeutic implications of cancer stem cells in glioblastoma 네이버 미소장
5 Main ginseng saponin metabolites formed by intestinal bacteria. 네이버 미소장
6 Ginsenoside Rh2 induces Bcl‐2 family proteins‐mediated apoptosis in vitro and in xenografts in vivo models 네이버 미소장
7 Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells 네이버 미소장
8 Ginseng saponin metabolite suppresses phorbol ester–induced matrix metalloproteinase‐9 expression through inhibition of activator protein‐1 and mitogen‐activated protein kinase signaling pathways in human astroglioma cells 네이버 미소장
9 Ki67 Predicts Progression in Early CIN: Validation of a Multivariate Progression-Risk Model 네이버 미소장
10 Ginsenoside rd in experimental stroke: superior neuroprotective efficacy with a wide therapeutic window. 네이버 미소장
11 Ginsenoside Rh2 Induces Apoptosis via Activation of Caspase-1 and -3 and Up-Regulation of Bax in Human Neuroblastoma 소장
12 Elevated levels of M(r) 92,000 type IV collagenase in human brain tumors. 네이버 미소장
13 Elevated Levels of Mr92,000 Type IV Collagenase during Tumor Growthin Vivo 네이버 미소장
14 Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas 네이버 미소장
15 Identification of human brain tumour initiating cells 네이버 미소장
16 Glioma stem cells promote radioresistance by preferential activation of the DNA damage response 네이버 미소장
17 CD133 + Renal Progenitor Cells Contribute to Tumor Angiogenesis 네이버 미소장

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