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Benzofuran-7-carboxamide was identified as a novel scaffold of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor. A series of compounds with various 2-substituents including (tertiary amino)methyl moieties substituted with aryl ring and aryl groups containing tertiary amines, were synthesized and biologically evaluated to elucidate the structure-activity relationships and optimize the potency. 2-[4-(Pyrrolidin-1-ylmethyl)phenyl]- benzofuran-7-carboxamide (42) was the most potent as an IC50 value of 40 nM among those.

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기사명 저자명 페이지 원문 목차
Green lighting upconversion in Yb^3+^, Er^3+^ co-doped PbWO₄ Jun Ho Chung, Sang Yeop Lee, Jong Won Eun, Kwang Bo Shim, Jeong Ho Ryu pp.1115-1116

Micron patterning of polydiacetylene supramolecules using micro-contact printing in conjunction with Langmuir-Blodgett deposition Seongil Yu, Heejoon Ahn, Jong-Man Kim pp.1117-1118

Characterization of two site-specifically modified human dihydrolipoamide dehydrogenase mutants : pro-282 to Ala and pro-298 to Ala Lin Yuan, Hakjung Kim pp.1119-1120

Synthesis, characterization and antioxidant activity of a novel organogermanium sesquioxide with resveratrol Shuguang Yao, Jinhuan Jiang, Peihui Yang, Jiye Cai pp.1121-1122

Prediction models of P-glycoprotein substrates using simple 2D and 3D descriptors by a recursive partitioning approach Jong Young Joung, Hyoungjoon Kim, Hwan Mook Kim, Soon Kil Ahn, Ky-Youb Nam, Kyoung Tai No pp.1123-1127

Photopatternable conducting polymer nanocomposite with incorporated gold nanoparticles for use in organic field effect transistors Sung Huh, Hyun Ho Choi, Kilwon Cho, Seung Bin Kim pp.1128-1134

A capillary electrochromatographic microchip packed with self-assembly colloidal carboxylic silica beads In-Sun Jeon, Shinseon Kim, Jongman Park pp.1135-1140

The characteristics of YAG:Ce phosphor powder prepared using a NO₃￣-malonic acid-NH₄NO₃-NH₃·H₂O system Jin An Jeong, Kyunghwan Park, Dong Hoon Lee, Hong Gun Kim, Yoo Young Kim pp.1141-1146

Studies on benzofuran-7-carboxamides as poly(ADP-ribose) polymerase-1(PARP-1) inhibitors Sunkyung Lee, Kyu Yang Yi, Byung Ho Lee, Kwang Seok Oh pp.1147-1153

A DABCO derived ionic liquid based on tetrafluoroborate anion : preparation, characterization and evaluation of its catalytic activity in the synthesis of 14-aryl-14H-dibenzo[a, j]xanthenes Atefeh Zare-Bidaki, Abolghasem Davoodnia pp.1154-1158

Anion sensing properties of new colorimetric chemosensors based on thiourea and urea moieties Dong Wan Kim, Junghwan Kim, Jaeyoung Hwang, Jong Keun Park, Jae Sang Kim pp.1159-1164

Enhancement of DNA-mediated energy transfer from ethidium to meso-tetrakis(N-methylpyridinium-4-yl)porphyrin by Ca^2+^ ion Jong-Moon Kim, Borami Park, Young Rhan Kim, Lindan Gong, Myung Duk Jang, Seog K. Kim pp.1165-1169

Efficient one-pot synthesis of acridinediones by indium(III) triflate-catalyzed reactions of β-enaminones, aldehydes, and cyclic 1,3-dicarbonyls Quang Huy To, Yong Rok Lee, Sung Hong Kim pp.1170-1176

Electrochemical properties of NiO-YSZ thin films on 316 stainless steel bipolar plates under a simulated PEMFC environment W.G. Lee, H. Jang pp.1177-1182

Development and evaluation of the Korea insecticide exposure model(KOIEM) for managing insecticides Ja Eun Jung, Yong-Ju Lee, Yoon Kwan Kim, Sungkyu Lee pp.1183-1189

Multi-electron donor organic molecules containing hydroquinone methyl-ether as redox active units Manish Khandelwal, In-Chul Hwang, Prakash Chandran R. Nair, Jung-Woo Lee pp.1190-1198

CO oxidation of catalytic filters consisting of Ni nanoparticles on carbon fiber Hyun Ook Seo, Jong Won Nam, Kwang-Dae Kim, Young Dok Kim, Dong Chan Lim pp.1199-1203

Nanocrystalline antimony oxide films for dye-sensitized solar cell applications Ji-Hye Kim, Jiyeon Jang, Sung-Chul Kim, Chi-Hwan Han, Seung-Joo Kim pp.1204-1208

Selective tandem synthesis of oximes from benzylic alcohols catalyzed with 2, 3-dichloro-5, 6-dicyanobenzoquinone Ghasem Aghapour, Samaneh Mohamadian pp.1209-1212

Theoretical studies on 2-hexylthieno[3,2-b]thiophene end-capped oligomers for organic semiconductor materials Young Hee Park, Yun-Hi Kim, Soon-Ki Kwon, In Sun Koo, Kiyull Yang pp.1213-1219

Enhancement of photocurrent efficiency in dye-sensitized solar cells using nanometer-sized Y-incorporated TiO₂ materials Sujung Kim, Min-Kyeong Yeo, Myeong-Heon Um, Misook Kang pp.1220-1224

A new unsymmetrical zinc phthalocyanine as photosensitizers for dye-sensitized solar cells Dan Zhang, Xue-Jun Zhang, Lei Zhang, Li-Jun Mao pp.1225-1230

Convenient one-pot synthesis of 2,4,5-triaryl-1H-imidazoles from arylaldehydes, benzyl alcohols, or benzyl halides with HMDS in the presence of molecular iodine Hojat Veisi, Ardashir Khazaei, Leila Heshmati, Saba Hemmati pp.1231-1234

Effects of Al concentration on structural and optical properties of Al-doped ZnO thin films Min Su Kim, Kwang Gug Yim, Jeong-Sik Son, Jae-Young Leem pp.1235-1241

Spectroscopic and morphological investigation of Co₃O₄ microfibers produced by electrospinning process J.H. Baek, J.Y. Park, A.R. Hwang, Y.C. Kang pp.1242-1246

Nano structured potentiometric sensors based on polyaniline conducting polymer for determination of Cr(VI) Ali Mohammad-khah, Reza Ansari, Ali Fallah Delavar, Zahra Mosayebzadeh pp.1247-1252

Structure-guided identification of novel phenolic and phenolic amide allosides from the rhizomes of cimicifuga heracleifolia Soon-Ho Yim, Hyun Jung Kim, Nari Jeong, Ki Deok Park, Young Ju Lee, Sung Dong Cho, Ik-Soo Lee pp.1253-1258

Syntheses, structures and luminescent properties of two novel M(II)-phen-SIP supramolecular compounds (M = Co, Ni) Yu-Lan Zhu, Shuai Shao, Kui-Rong Ma, Xue-Ling Tang, Li Cao, Hui-Chao Zhao pp.1259-1263

Rational design of coordination polymers with flexible oxyethylene side chains Eun-Young Choi, Chunji Gao, Suck-Hyun Lee, O-Pil Kwon pp.1264-1268

Enhanced visible light activity and stability of TiO₂ nanopowder by co-doped with Mo and N Shaozheng Hu, Fayun Li, Zhiping Fan pp.1269-1274

A mild and efficient trispentafluorophenyl borane-catalyzed Sakurai allylation of N-benzyloxycarbonylamino p-tolylsulfone with allyltrimethylsilane Ponnaboina Thirupathi, Lok Nath Neupane, Keun-Hyeung Lee pp.1275-1278

Effective liquid-phase nitration of benzene catalyzed by a stable solid acid catalyst : silica supported Cs_2.5_H_0.5_PMo_12_O_40_ Gong Shu-wen, Liu Li-jun, Zhang Qian, Wang Liang-yin pp.1279-1284

Effects of a phosphomimetic mutant of RAP80 on linear polyubiquitin binding probed by calorimetric analysis Thanh Trung Thach, JunGoo Jee, Sangho Lee pp.1285-1289

Effect of pH on the iron autoxidation induced DNA cleavage Jong-Moon Kim, Byul Nim Oh, Jin-Heung Kim, Seog K. Kim pp.1290-1296

The interaction of CO to the Cosalen complex in to PEDOT:PSS film and sensor application Raheleh Memarzadeh, Farhad Panahi, Sirus Javadpour, Ali Khalafi-Nezhad, Hui-Bog Noh, Yoon-Bo Shim pp.1297-1302

The co-luminescence groups of Sm-La-pyridyl carboxylic acids and the binding characteristics between the selected doped complex and bovine serum albumin Zhengfa Yang, Ruiren Tang, Chunhua Tang pp.1303-1309

Synthesis and antibacterial activity of novel 2-oxo-pyrrolidinyl oxazolidinones Deepak Bhattarai, Sun Hee Lee, Hyeong Kyu Kim, Soon Bang Kang, Ae Nim Pae, Eunice Eunkyeong Kim, Taegwon Oh, Sang-Nae Cho, Gyochang Keum pp.1310-1316

Preparation of self-assembled crystalline microparticles with bispyridyl Zn-porphyrin Dahee Lee, Suk Joong Lee pp.1317-1320

Synthesis and nonlinear optical properties of novel Y-type polyimide containing dioxynitroazobenzene group Mi Sung Kim, Byeongman Jeon, Ju-Yeon Lee pp.1321-1324

Gold-catalyzed homocoupling reaction of terminal alkynes to 1,3-diynes Mei Zhu, Ma Ning, Weijun Fu, Chen Xu, Guanglong Zou pp.1325-1328

Synthesis and characterization of new reinforced pentaaza macrobicyclic and bis(macrobicyclic) copper(II) complexes Hyunja Kim, Shin-Geol Kang, Soo-Kyung Jeong pp.1329-1332

The depigmenting activities of hydroxyl carboxamide derivatives containing hydrophobic moiety Jun-Cheol Cho, Ho Sik Rho, Yung Hyup Joo, Soo Mi Ahn, Doo Hyun Won, Song Seok Shin, Young-Ho Park, Kyung-Do Suh, Soo Nam Park pp.1333-1336

Facile synthesis of 5-alkylidene-1,5-dihydropyrrol-2-ones from Morita-Baylis-Hillman adducts Bo Ram Park, Cheol Hee Lim, Jin Woo Lim, Jae Nyoung Kim pp.1337-1340

A gold nanoparticles-based colorimetric assay for DNA-binding molecules using non-cross-linking aggregation Min Sik Eom, Yoon Seo Lee, Min Su Han pp.1341-1344

Silica in water : a potentially valuable reaction medium for the synthesis of pyrano[2,3-c]pyrazoles Pravin V. Shinde, Jitendra B. Gujar, Bapurao B. Shingate, Murlidhar S. Shingare pp.1345-1348

Synthesis and crystal structure of a 3D samarium-organic framework containing vacant chelating sites Suhyun Jung, Youngmee Kim, Sung-Jin Kim, Seongsoon Park pp.1349-1352

Synthesis, characterization and application of dendritic lipids for gene delivery Hyung-Suk Jang, Yan Lee, Tae-Il Kim, Jong-Sang Park, Joon Sig Choi pp.1353-1356

Controlled C-5 chlorination and dichlorohydrin formation of uracil ring with HCl/DMF/Oxone^®^ system Hyun Seung Lee, Hyun Ju Lee, Ka Young Lee, Jae Nyoung Kim pp.1357-1359

Tricuspone, a rearranged diterpenoid from Salvia tricuspis Hong-Bo Zheng, Teng Zhang, Kyung-Ho Row, Wei-Dong Xie pp.1360-1362

Fabrication of superhydrophobic surface on magnesium substrate by chemical etching Munhee Han, Seungcheol Go, Yonghyun Ahn pp.1363-1366

Luminescence quenching of a novel phosphorescent Ir(III) complex/MWCNT hybrid Jung Oh Huh, Sungjin Park, Insung S. Choi, Youngkyu Do pp.1367-1370

A regioselective synthesis of multi-substituted 2-imino-1,3-oxazolines by one-pot reaction Minsoo Han, Hoh-Gyu Hahn pp.1371-1374

An efficient synthesis of heterocyclic analogues of thioflavones from haloheteroaromatic acids Jae In Lee pp.1375-1378

An effective synthesis of 3-methoxyflavones via1-2-hydroxyphenyl -2-methoxy-3-phenyl-1,3-propanediones Jae In Lee, Se Bin Park pp.1379-1382

Monophosphine-cyclopalladated ferrocenylpyrimidine complex : synthesis, crystal structure and reusable catalytic system for coupling reaction of aryl chlorides in PEG-400 Chen Xu, Lu-Meng Duan, Zhen Li, Xin-Hua Lou, Zhi-Qiang Wang, Yao-Ting Fan pp.1383-1385

Preparation of a thiolated derivative of A2E, a pigment of the lipofuscin of retinal pigment epithelial cells Donghee Chung, Ho-Jung Kang, Young Pyo Jang, Woong Jung, Sang Soo Hah pp.1386-1388

A new method for the oxazolidinone key intermediate of linezolid and its formal synthesis HoonGyu Park, Bojung Kim, Daeil Bae, Byungjo Lim, Misun Ko, Sehan Oh, Hakwon Kim pp.1389-1392

Synthesis of unsymmetrical Frechet-type dendrimers via double click chemistry Seung Choul Han, Seung Hwan Kwak, Sung-Ho Jin, Jae Wook Lee pp.1393-1396

Phosphoric acid-functionalized mesoporous silica/nafion composite membrane for high temperature PEMFCs Jongwon Lee, Cheol-Woo Yi, Keon Kim pp.1397-1400

Covalently assembled bifunctional copolymer layers as a matrix for immobilization of oligonucleotides Jeongsun Kim, Sangwook Yoo, Jungahn Kim, Joohoon Kim pp.1401-1404

Identification of antimycin A as a small molecule inhibitor of the Wnt/β-catenin pathway Sangtaek Oh pp.1405-1408

Functionalized Ni@SiO2 core/shell magnetic nanoparticles as a chemosensor for fluoride ion Minsung Park, Ki-Young Kwon, Jong Hwa Jung pp.1409-1412

Density functional theoretical study on the hydricities of (η⁵-C₅H₅)M(CO)₂H(M = Fe, Ru, and Os) in acetonitrile Youngseuk Cho, Jaebeom Lee, Sungu Hwang pp.1413-1415

참고문헌 (15건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Jagtap, P., Szabo, C. Nat. Rev. Drug Discovery 2005, 4, 421. 미소장
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3 Rouleau, M., Patel, A., Hendzel, M. J., Kaufmann, S. H., Poirier, G. G. Nat. Rev. Cancer 2010, 10, 293. 미소장
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7 Griffin, R. J., Pemberton, L. C., Rhodrs, D., Bleasdale, C., Bowman, K., Calvert, A. H., Curtin, N. J., Durkacz, B. W., Newell, D. R. Anti-Cancer Drug Dis. 1995, 10, 507. 미소장
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9 Ando, K., Kawamura, Y., Akai, Y., Kunitomo, J.-I., Yokomizo, T., Yamashita, M., Ohta, S., Ohishi, T. Org. Biomol. Chem. 2008, 6, 296. 미소장
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14 Hattori, K., Kido, Y., Yamamoto, H., Ishida, J., Kamijo, K., Murano, K., Ohkubo, M., Kinoshita, T., Iwashita, A., Mihara, K., Yamazaki, S., Matsuoka, N., Teramura, Y., Miyake, H. J. Med. Chem. 2004, 47, 4151. 미소장
15 Koch, S. S. C., Thoresen, L. H., Tikhe, J. G., Maegley, K. A., Almassy, R. J., Li, J., Yu, X.-H., Zook, S. E., Kumpf, R. A., Zhang, C., Boritzki, T. J., Mansour, R. N., Zhang, K. E., Ekker, A. Calabrese, C. R., Curtin, N. J., Kyle, S., Thomas, H. D., Wang, L.- Z., Calvert, A. H., Golding, B. T., Griffin, R. J., Newell, D. R., Webber, S. E., Hostomsky, Z. J. Med. Chem. 2002, 45, 4961. 미소장

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